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Research Progress on the Toxic Antagonism of Selenium Against Mycotoxins

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Abstract

Animal feed is prone to becoming infected with molds during production and storage, resulting in secondary metabolite mycotoxins, such as aflatoxin B1 (AFB1), T-2 toxins, deoxynivalenol (DON), and ochratoxin A (OTA), which are harmful to humans and animals. Selenium is an essential trace element for humans and animals, and it is also an effective antioxidant. Many studies have shown that selenium can reduce the damage caused by mycotoxins in animals. This article reviews the current literature on the antagonistic effects of selenium on AFB1, T-2, DON, and OTA toxicity.

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Acknowledgments

We thank Kate Fox, DPhil, from Liwen Bianji, Edanz Group China (www.liwenbianji.cn/ac), for editing the English text of a draft of this manuscript.

Funding

The present work was supported by the National Natural Science Fund of China (31402269) and the Changjiang Scholars & Innovative Research Team of the Ministry of Education of China Funds (Grant no. IRTO848).

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  1. Zhihua Ren and Hongyi He contributed equally to this work and should be considered co-first authors.

Authors and Affiliations

  1. College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China

    Zhihua Ren, Hongyi He, Yu Fan, Changhao Chen, Zhicai Zuo & Junliang Deng

  2. Sichuan Province Key Laboratory of Animal Disease & Human Health, Chengdu, China

    Zhihua Ren, Hongyi He, Yu Fan, Changhao Chen, Zhicai Zuo & Junliang Deng

  3. Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Chengdu, 611130, China

    Zhihua Ren, Hongyi He, Yu Fan, Changhao Chen, Zhicai Zuo & Junliang Deng

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Ren, Z., He, H., Fan, Y. et al. Research Progress on the Toxic Antagonism of Selenium Against Mycotoxins. Biol Trace Elem Res 190, 273–280 (2019). https://doi.org/10.1007/s12011-018-1532-6

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