Biological Trace Element Research

, Volume 188, Issue 2, pp 295–315 | Cite as

Health Effects of Trace Metals in Electronic Cigarette Aerosols—a Systematic Review

  • Sumit Gaur
  • Rupali AgnihotriEmail author


Electronic cigarettes (ECs) are essentially nicotine delivery devices that mimic the appearance of a conventional cigarette (CC). Lately, they have been marketed as tools for quitting smoking. Even though they are promoted as safe alternatives to CC, they are not devoid of hazardous components. Literature reveals that the EC aerosols and e-liquids are a potential source of elements that induce and promote development of chronic conditions. These include trace metals which are leached from their core assembly. Some of these metals like nickel, chromium, cadmium, tin, aluminum, and lead are potential carcinogens. They have been associated with fatal conditions like lung and sinonasal cancer. Besides, they may have adverse effects on oral tissues like periodontal ligament and mucosa where they may trigger chronic periodontitis and oral cancer. However, there is only trivial evidence related to health hazards of metals released from ECs. With this background, the present review first focuses on the structure of the ECs followed by an appraisal of the data from experimental studies about the metals released in EC aerosols and their associated health hazards.


Chromium Cadmium Electronic cigarettes Health Lead Nickel Trace metals Vaping 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.


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Authors and Affiliations

  1. 1.Department of Pedodontics and Preventive Dentistry, Manipal College of Dental Sciences, ManipalManipal Academy of Higher Education (MAHE)ManipalIndia
  2. 2.Department of Periodontology, Manipal College of Dental Sciences, ManipalManipal Academy of Higher Education (MAHE)ManipalIndia

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