Skip to main content
Log in

Evaluation of Arsenic, Cadmium, Nickel and Lead in Common Spices in Pakistan

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

The quantitative assessments and daily intake of arsenic (As), cadmium (Cd), nickel (Ni) and lead (Pb) were conducted in the 26 common spices collected from the market of Hyderabad, Pakistan. Conventional acid digestion procedure was applied for dissolution of common spices and the contents of toxic elemental were determined by graphite furnace atomic absorption spectrometry. The conventional acid digestion method was validated by certified reference materials and standard addition. A wide variability was observed in the levels of toxic elements in common spices. The toxic elements in common spices were found in decreasing order as Ni > Pb > As > Cd. The contents of As, Cd, Ni and Pb in common spices were observed highest in coriander seed, allspices, nigella seed and black cumin seed, respectively. The current study revealed that the toxic elements in common spices were varied from region to region. However, the estimated intake of As, Cd, Ni and Pb from common spices were within the WHO tolerable weekly intake. The data of risk assessment indicated that As, Cd, Ni, and Pb in common spices may not have any toxic risk except the As in carom, coriander and nigella seeds.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Schweiggert U, Carle R, Schieber A (2007) Conventional and alternative processes for spice production–a review. Trends Food Sci Technol 18(5):260–268

    Article  CAS  Google Scholar 

  2. Ninfali P, Mea G, Giorgini S, Rocchi M, Bacchiocca M (2005) Antioxidant capacity of vegetables, spices and dressings relevant to nutrition. Br J Nutr 93(2):257–266

    Article  CAS  Google Scholar 

  3. Bhattacharjee S, Sengupta A (2009) Spices in cancer prevention: an overview. Internet J Nutr Wellness 7(1):13

    Google Scholar 

  4. Albayrak S, Aksoy A, Sagdic O, Albayrak S (2012) Antioxidant and antimicrobial activities of different extracts of some medicinal herbs consumed as tea and spices in Turkey. J Food Biochem 36(5):547–554

    Article  CAS  Google Scholar 

  5. Wungsintaweekul J, Sitthithaworn W, Putalun W, Pfeifhoffer HW, Brantner A (2010) Antimicrobial, antioxidant activities and chemical composition of selected Thai spices. Sonklanakarin Journal of Science and Technology 32(6):589

    CAS  Google Scholar 

  6. Bythrow JD (2005) Vanilla as a medicinal plant. In: Seminars in integrative medicine. Elsevier, pp 129–131, 3

  7. Melnyk JP, Wang S, Marcone MF (2010) Chemical and biological properties of the world’s most expensive spice: saffron. Food Res Int 43(8):1981–1989

    Article  CAS  Google Scholar 

  8. Nkansah MA, Amoako CO (2010) Heavy metal content of some common spices available in markets in the Kumasi metropolis of Ghana. American Journal of Scientific and Industrial Research 1(2):158–163

    Article  Google Scholar 

  9. Thomas F, Daoust SP, Raymond M (2012) Can we understand modern humans without considering pathogens? Evol Appl 5(4):368–379

    Article  Google Scholar 

  10. Amate CF, Unterluggauer H, Fischer R, Fernández-Alba A, Masselter S (2010) Development and validation of a LC–MS/MS method for the simultaneous determination of aflatoxins, dyes and pesticides in spices. Anal Bioanal Chem 397(1):93–107

    Article  Google Scholar 

  11. Karadaş C, Kara D (2012) Chemometric approach to evaluate trace metal concentrations in some spices and herbs. Food Chem 130(1):196–202

    Article  Google Scholar 

  12. Uluozlu OD, Tuzen M, Mendil D, Soylak M (2007) Trace metal content in nine species of fish from the Black and Aegean Seas, Turkey. Food Chem 104(2):835–840

    Article  CAS  Google Scholar 

  13. Ozkutlu F, Sekeroglu N, Kara SM (2006) Monitoring of cadmium and micronutrients in spices commonly consumed in Turkey. Res J Agric Biol Sci 2(5):223–226

    Google Scholar 

  14. Liang J, Wang Q, Huang B (2004) Concentrations of hazardous heavy metals in environmental samples collected in Xiamen, China, as determined by vapor generation non-dispersive atomic fluorescence spectrometry. Anal Sci 20(1):85–88

    Article  CAS  Google Scholar 

  15. Yusuf A, Arowolo T, Bamgbose O (2003) Cadmium, copper and nickel levels in vegetables from industrial and residential areas of Lagos City, Nigeria. Food Chem Toxicol 41(3):375–378

    Article  CAS  Google Scholar 

  16. Adams M, Zhao F, McGrath S, Nicholson F, Chambers B (2004) Predicting cadmium concentrations in wheat and barley grain using soil properties. J Environ Qual 33(2):532–541

    Article  CAS  Google Scholar 

  17. Caldas E, Machado L (2004) Cadmium, mercury and lead in medicinal herbs in Brazil. Food Chem Toxicol 42(4):599–603

    Article  CAS  Google Scholar 

  18. Chizzola R, Michitsch H, Franz C (2003) Monitoring of metallic micronutrients and heavy metals in herbs, spices and medicinal plants from Austria. Eur Food Res Technol 216(5):407–411

    Article  CAS  Google Scholar 

  19. Inam F, Deo S, Narkhede N (2013) Analysis of minerals and heavy metals in some spices collected from local market. J Phar Bio Sci 8(2):40–43

    Google Scholar 

  20. Seddigi Z, Kandhro G, Shah F, Danish E, Soylak M (2016) Assessment of metal contents in spices and herbs from Saudi Arabia. Toxicol Ind Health 32(2):260–269

    Article  CAS  Google Scholar 

  21. Rathee P, Hooda A, Sushila S (2015) Estimation herb/spice/vegetables trace elements: north-west regional states of haryana (India). Asian J Pharm Technol Innov 3(10):15–20

    CAS  Google Scholar 

  22. Mubeen H, Naeem I, Taskeen A, Saddiqe Z (2009) Investigations of heavy metals in commercial spices brands. N Y Sci J 2(5):20–26

    Google Scholar 

  23. Goswami K, Mazumdar I (2014) Lead poisoning and some commonly used spices: an Indian scenario. Int J Agric Innov Res 3(2):433

    Google Scholar 

  24. WHO (2006) WHO guidelines for assessing quality of herbal medicines with reference to contaminants and residues. World Health Organization, Geneva, Switzerland

    Google Scholar 

  25. Khan N, Choi JY, Nho EY, Jamila N, Habte G, Hong JH, Hwang IM, Kim KS (2014) Determination of minor and trace elements in aromatic spices by micro-wave assisted digestion and inductively coupled plasma-mass spectrometry. Food Chem 158:200–206

    Article  CAS  Google Scholar 

  26. Ansari T, Ikram N, Najam-ul-Haq M, Fayyaz I, Fayyaz Q, Ghafoor I, Khalid N (2004) Essential trace metal (zinc, manganese, copper and iron) levels in plants of medicinal importance. J Biol Sci 4(2):95–99

    Article  Google Scholar 

  27. EPA U (2005) Supplemental guidance for assessing cancer susceptibility from early-life exposure to carcinogens. Risk Assessment Forum, Washington, DC

    Google Scholar 

  28. EPA U (1989) Risk assessment guidance for Superfund, vol. I: human health evaluation manual. EPA/540/1-89/002. Office of Solid Waste and Emergency Response Available at: https://www.epa.gov/sites/production/files/2015-09/documents/rags_a.pdf [Accessed 26 September 2016]

  29. USEPARA F (2005a) Guidelines for carcinogen risk assessment. Risk Assessment Forum. Agency, US Environmental Protection

  30. Singare PU, Talpade MS (2013) Study on toxic heavy metals in Indian carp (C. catla) and vegetation of Bhavan’s College Lake of Andheri, Mumbai. Interdiscip Environ Rev 14(1):59–68

    Article  Google Scholar 

  31. Jabeen S, Shah MT, Khan S, Hayat MQ (2010) Determination of major and trace elements in ten important folk therapeutic plants of Haripur basin. Pak J Med Plants Res 4(7):559–566

    CAS  Google Scholar 

  32. Kapaj S, Peterson H, Liber K, Bhattacharya P (2006) Human health effects from chronic arsenic poisoning–a review. J Environ Sci Health A 41(10):2399–2428

    Article  CAS  Google Scholar 

  33. Krejpcio Z, Krol E, Sionkowski S (2007) Evaluation of heavy metals contents in spices and herbs available on the polish market. Pol J Environ Stud 16(1)

  34. Ibrahim G, Hassan L, Baban S, Fadhil S (2012) Effect of heavy metal content of some common spices available in local markets in Erbil city on human consumption. Raf J Sci 23(3):106–114

    Google Scholar 

  35. Al-Eed M, Assubaie F, El-Garawany M, El-Hamshary H, El-Tayeb Z (2002) Determination of heavy metal levels in common spices. J Appl Sci 17:87–98

    Google Scholar 

  36. Organization WH (1996) Trace elements in human nutrition and health. World Health Organization

  37. Joint F, Additives WECoF (2003) Summary and conclusions of sixty-first meeting. ftp://ftp fao org/es/esn/jecfa/jecfa61sc pdf

  38. Temiz H, Soylu A (2012) Heavy metal concentrations in raw milk collected from different regions of Samsun, Turkey. Int J Dairy Technol 65(4):516–522

    Article  CAS  Google Scholar 

  39. Tseng C-H, Huang Y-K, Huang Y-L, Chung C-J, Yang M-H, Chen C-J, Hsueh Y-M (2005) Arsenic exposure, urinary arsenic speciation, and peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan. Toxicol Appl Pharmacol 206(3):299–308

    Article  CAS  Google Scholar 

  40. Mukherjee SC, Saha KC, Pati S, Dutta RN, Rahman MM, Sengupta MK, Ahamed S, Lodh D, Das B, Hossain MA (2005) Murshidabad—one of the nine groundwater arsenic-affected districts of West Bengal, India. Part II: dermatological, neurological, and obstetric findings. Clin Toxicol 43(7):835–848

    Article  CAS  Google Scholar 

  41. Baig JA, Kazi TG, Shah AQ, Afridi HI, Khan S, Kolachi NF, Kandhro GA, Wadhwa SK, Shah F (2011) Evaluation of toxic risk assessment of arsenic in male subjects through drinking water in southern Sindh Pakistan. Biol Trace Elem Res 143(2):772–786

    Article  CAS  Google Scholar 

  42. Baig JA, Kazi TG, Mustafa MA, Solangi IB, Mughal MJ, Afridi HI (2016) Arsenic exposure in children through drinking water in different districts of Sindh, Pakistan. Biol Trace Elem Res 173(1):35–46

    Article  CAS  Google Scholar 

  43. Brahman KD, Kazi TG, Afridi HI, Arain SS, Kazi AG, Talpur FN, Baig JA, Panhwar AH, Arain MS, Ali J (2016) Toxic risk assessment of arsenic in males through drinking water in Tharparkar Region of Sindh, Pakistan. Biol Trace Elem Res 172(1):61–71

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jameel Ahmed Baig.

Ethics declarations

Ethical approval was obtained from the ethical review committee of University of Sindh, Jamshoro, Pakistan

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Baig, J.A., Bhatti, S., Kazi, T.G. et al. Evaluation of Arsenic, Cadmium, Nickel and Lead in Common Spices in Pakistan. Biol Trace Elem Res 187, 586–595 (2019). https://doi.org/10.1007/s12011-018-1400-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12011-018-1400-4

Keywords

Navigation