Selenium-Rich Yeast Protects Against Aluminum-Induced Renal Inflammation and Ionic Disturbances

  • Changyu Cao
  • Junchong Luo
  • Xiaowen Li
  • Mengdan Zhang
  • Haoji Zhang
  • Jipei Zhang
  • Kai Wang


The aim of this study was to evaluate the protective effects of SeY (selenium-rich yeast) against Al (aluminum)-induced inflammation and ionic imbalances. Male Kunming mice were treated with Al (10 mg/kg) and/or SeY (0.1 mg/kg) by oral gavage for 28 days. The degree of inflammation was assessed by mRNA expression of inflammatory biomarkers. Ionic disorders were assessed by determining the Na+, K+, and Ca2+ content, as well as the alteration in ATP-modifying enzymes (ATPases), including Na+K+-ATPase, Ca2+-ATPase, Mg2+-ATPase, Ca2+Mg2+-ATPase, and the mRNA levels of ATPase’s subunits in kidney. It was observed here that SeY exhibited a significant protective effect on the kidney against the Al-induced upregulation of pro-inflammatory and downregulation of anti-inflammatory cytokines. Furthermore, a significant effect of Al on the Na+, K+, Ca2+, and Mg2+ levels in kidney was observed, and Al was observed to decrease the activities of Na+K+-ATPase, Mg2+-ATPase, and Ca2+Mg2+-ATPase. The mRNA expression of the Na+K+-ATPase subunits and Ca2+-ATPase subunits was regulated significantly by Al. Notably, SeY modulated the Al-induced alterations of ion concentrations, ATPase activity, and mRNA expression of their subunits. These results suggest that SeY prevents renal toxicity caused by Al via regulation of inflammatory responses, ATPase activities, and transcription of their subunits.


Aluminum Selenium-rich yeast Inflammation Ionic homeostasis Mouse kidney 


Funding information

This work was supported by Foshan University research star-up project (099/gg07037).

Compliance with Ethical Standards

All animal studies reported here were approved by the Institutional Animal Care and Use Committee of the Foshan University.

Conflict of Interest

The authors declare that they have no conflict of interest.

Supplementary material

12011_2018_1324_MOESM1_ESM.doc (30 kb)
ESM 1 (DOC 30 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.College of Life Science and EngineeringFoshan UniversityFoshanPeople’s Republic of China

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