Abstract
Oxidative stress and inflammation are candidate mechanisms to explain the potential role of exposure to metals and reduced activity of paraoxonase-1 (PON1) in age-related diseases. Both may be risk factors contributing to atherosclerosis. In the present study, inductively coupled mass spectrometry was used to explore multiple trace elements, while in-house methods were employed to measure PON1-related variables in patients with lower extremity artery disease (LEAD). Healthy controls were matched for sex, age, body weight, and relevant genotype variants. Serum concentrations of As, Ba, Cu, and Sr were higher in patients than those in controls, with a strong predictive ability to discriminate between groups. Differences in serum Pb, Cd, and Zn were negligible. Serum Cu increased when the disease was more severe, but a negative trend was noted for serum As, B, Ba, and Zn. The only variable associated with ankle-brachial index was serum Zn. Serum PON1 activity was significantly lower in LEAD patients. When the ability of serum trace elements to modulate PON1 activity was explored, the analysis revealed a unique association with serum Zn. The current results strongly suggest that Zn may have a protective effect in non-coronary atherosclerosis and indicate that this element may exert its anti-inflammatory and antioxidant functions through interactions with PON1 activity. These findings deserve confirmation and further research. In particular, the periodic evaluation of serum trace elements and the prescription of Zn supplements are easy measures to implement and that can improve the treatment of patients with LEAD.
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Funding
J. Rovira received funds from Health Department of Catalonia Government, through “Pla Estratègic de Recerca i Innovació en salut” (PERIS 2016–2020) fellowship (SLT002/16/00094). A. Hernández is the recipient of a fellowship of Fundació La Marató de TV3. Current work in our laboratories is supported by grants from the Plan Nacional de I+D+I, Spain, Instituto de Salud Carlos III (PI15/00285, co-founded by the European Regional Development Fund [FEDER]), the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) (2014 SGR1227), and the Fundació La Marató de TV3.
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MN, JC, JJ, and JLD designed the study. VMP recruited patients for the study and managed data collection. JR, AHA, FLM, NC, and GBG performed the analyses and collected data. JR and AHA performed the statistical analyses. JC, JJ, and JLD wrote the manuscript which was revised and accepted by all authors.
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The authors declare that they have no conflict of interest.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee.
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Informed consent was obtained from all individual participants included in the study.
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Rovira, J., Hernández-Aguilera, A., Luciano-Mateo, F. et al. Trace Elements and Paraoxonase-1 Activity in Lower Extremity Artery Disease. Biol Trace Elem Res 186, 74–84 (2018). https://doi.org/10.1007/s12011-018-1298-x
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DOI: https://doi.org/10.1007/s12011-018-1298-x