Biological Trace Element Research

, Volume 184, Issue 1, pp 127–135 | Cite as

Effect of Selenium on Ion Profiles and Antioxidant Defense in Mice Livers

  • Bingxin Li
  • Yang Liu
  • Wanyan Li
  • Yunbo Tian
  • Danning Xu
  • Nan Cao


Se entering the mammalian body from diverse sources shows different liver accumulation patterns. However, the effects of Se from diverse sources on the body’s I on spectrum and the relationship between the changes in the ion spectrum and antioxidant function are not clear. In this study, 80 3-week-old female mice were randomly divided into four groups: a control group, sodium selenite group, yeast Se group, and seaweed Se group. The estimated Se contents were 0.03, 0.23, 0.23, and 0.23 mg/kg, respectively. The liver was collected from mice on day 60. The results showed that, compared with the control group, sodium selenite significantly reduced Na and Li contents and significantly increased Cr, Ni, Se, and Sb contents (P < 0.05); yeast Se significantly increased Mg, Ca, Si, Cr, Fe, Co, Cu, Se, Sb, and Al contents, and significantly reduced Tl, As, and Hg contents (P < 0.05); seaweed Se significantly increased B, Si, Cr, Fe, Se, As, and Hg contents, and significantly reduced Zn and Tl contents (P < 0.05). The results of antioxidant parameter analysis showed that Se from three sources increased total superoxide dismutase content and significantly reduced malondialdehyde content (P < 0.05), whereas no clear effect was observed on total antioxidant capacity (P > 0.05). Combined with the ion spectrum and antioxidant test results, yeast Se was found to most effectively promote the accumulation of beneficial elements, enhance antioxidant capacity, and reduce the concentration of toxic elements. The variety of ion spectrum antioxidants followed a similar trend, which indicated that the ion spectrum might be related to antioxidant activity.


Selenium Liver Ion spectrum Antioxidation 



We acknowledge the support of Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, Guangzhou 510225, China.


This work was supported by the National Natural Science Foundation of China (No. 31402162), Science & Technology Planning Project of Guangzhou (No. 201604020061), National Key Technologies R & D Program of China (No. 2016YFD0501605), and Science & Technology Planning Project of Guangdong Province (No. 2015B020202012).


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Zhongkai University of Agriculture and EngineeringGuangzhouChina

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