Effect of Selenium on Ion Profiles and Antioxidant Defense in Mice Livers

Article

Abstract

Se entering the mammalian body from diverse sources shows different liver accumulation patterns. However, the effects of Se from diverse sources on the body’s I on spectrum and the relationship between the changes in the ion spectrum and antioxidant function are not clear. In this study, 80 3-week-old female mice were randomly divided into four groups: a control group, sodium selenite group, yeast Se group, and seaweed Se group. The estimated Se contents were 0.03, 0.23, 0.23, and 0.23 mg/kg, respectively. The liver was collected from mice on day 60. The results showed that, compared with the control group, sodium selenite significantly reduced Na and Li contents and significantly increased Cr, Ni, Se, and Sb contents (P < 0.05); yeast Se significantly increased Mg, Ca, Si, Cr, Fe, Co, Cu, Se, Sb, and Al contents, and significantly reduced Tl, As, and Hg contents (P < 0.05); seaweed Se significantly increased B, Si, Cr, Fe, Se, As, and Hg contents, and significantly reduced Zn and Tl contents (P < 0.05). The results of antioxidant parameter analysis showed that Se from three sources increased total superoxide dismutase content and significantly reduced malondialdehyde content (P < 0.05), whereas no clear effect was observed on total antioxidant capacity (P > 0.05). Combined with the ion spectrum and antioxidant test results, yeast Se was found to most effectively promote the accumulation of beneficial elements, enhance antioxidant capacity, and reduce the concentration of toxic elements. The variety of ion spectrum antioxidants followed a similar trend, which indicated that the ion spectrum might be related to antioxidant activity.

Keywords

Selenium Liver Ion spectrum Antioxidation 

Notes

Acknowledgements

We acknowledge the support of Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, Guangzhou 510225, China.

References

  1. 1.
    Gao H et al (2016) Effects of dietary selenium against lead toxicity on mRNA Levels of 25 selenoprotein genes in the cartilage tissue of broiler chicken. Biol Trace Elem Res 172(1):234–241CrossRefPubMedGoogle Scholar
  2. 2.
    Yang Z et al (2016) Selenium deficiency mainly influences antioxidant selenoproteins expression in broiler immune organs. Biol Trace Elem Res 172(1):209–221CrossRefPubMedGoogle Scholar
  3. 3.
    Huang Z, Rose AH, Hoffmann PR (2012) The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 16(7):705–743CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Leeson S et al (2008) Comparison of selenium levels and sources and dietary fat quality in diets for broiler breeders and layer hens. Poult Sci 87(12):2605–2612CrossRefPubMedGoogle Scholar
  5. 5.
    Delezie E et al (2014) Comparing responses to different selenium sources and dosages in laying hens. Poult Sci 93(12):3083–3090CrossRefPubMedGoogle Scholar
  6. 6.
    Luan Y et al (2016) Selenium deficiency influences the mRNA expression of selenoproteins and cytokines in chicken erythrocytes. Biol Trace Elem Res 171(2):427–436CrossRefPubMedGoogle Scholar
  7. 7.
    Kieliszek M, Błażejak S, Kurek E (2017) Binding and conversion of selenium in Candida utilis ATCC 9950 yeasts in bioreactor culture[J]. Molecules 22(3):352Google Scholar
  8. 8.
    Yan X et al (2004) Enriched accumulation and biotransformation of selenium in the edible seaweed Laminaria japonica. J Agric Food Chem 52(21):6460–6464CrossRefPubMedGoogle Scholar
  9. 9.
    Mahan DC et al (2014) Supplementation of organic and inorganic selenium to diets using grains grown in various regions of the United States with differing natural Se concentrations and fed to grower-finisher swine. J Anim Sci 92(11):4991–4997CrossRefPubMedGoogle Scholar
  10. 10.
    Li JL et al (2017) Effects of different selenium sources on growth performance, antioxidant capacity and meat quality of local Chinese Subei chickens. Biol Trace Elem Res.  https://doi.org/10.1007/s12011-017-1049-4
  11. 11.
    Marettová E et al (2012) The retention of cadmium and selenium influence in fowl and chickens of F1 generation. Biol Trace Elem Res 147(1–3):130–134CrossRefPubMedGoogle Scholar
  12. 12.
    Xu T, Gao X, Liu G (2016) The antagonistic effect of selenium on lead toxicity is related to the ion profile in chicken liver. Biol Trace Elem Res 169(2):365–373CrossRefPubMedGoogle Scholar
  13. 13.
    Erkekoglu P et al (2015) The effects of di(2-ethylhexyl) phthalate and/or selenium on trace element levels in different organs of rats. J Trace Elem Med Biol 29:296–302CrossRefPubMedGoogle Scholar
  14. 14.
    Sun B, Xing M (2016) Evaluated the Twenty-Six Elements in the pectoral muscle of as-treated chicken by inductively coupled plasma mass spectrometry. Biol Trace Elem Res 169(2):359–364CrossRefPubMedGoogle Scholar
  15. 15.
    Pappas AC et al (2011) Influence of organic selenium supplementation on the accumulation of toxic and essential trace elements involved in the antioxidant system of chicken. Food Additives & Contaminants: Part A 28(4):446–454CrossRefGoogle Scholar
  16. 16.
    Ognjanovic BI et al (2008) Effect of chronic cadmium exposure on antioxidant defense system in some tissues of rats: protective effect of selenium. Physiol Res 57(3):403–411PubMedGoogle Scholar
  17. 17.
    Liu L et al (2014) Protective roles of selenium on nitric oxide-mediated apoptosis of immune organs induced by cadmium in chickens. Biol Trace Elem Res 159(1–3):199–209CrossRefPubMedGoogle Scholar
  18. 18.
    Kumar M et al (2012) Selenium and spermine alleviate cadmium induced toxicity in the red seaweed Gracilaria dura by regulating antioxidants and DNA methylation. Plant Physiol Biochem 51:129–138CrossRefPubMedGoogle Scholar
  19. 19.
    Zamani Moghaddam AK et al (2017) role of selenium from different sources in prevention of pulmonary arterial hypertension syndrome in broiler chickens. Biol Trace Elem Res.  https://doi.org/10.1007/s12011-017-0993-3
  20. 20.
    Chen F et al (2017) Selenium-enriched Saccharomyces cerevisiae improves growth, antioxidant status and selenoprotein gene expression in Arbor Acres broilers. J Anim Physiol Anim Nutr 101(2):259–266CrossRefGoogle Scholar
  21. 21.
    Čobanová K et al (2017) Effects of different dietary selenium sources on antioxidant status and blood phagocytic activity in sheep. Biol Trace Elem Res 175(2):339–346CrossRefPubMedGoogle Scholar
  22. 22.
    Fairweather-Tait SJ, Collings R, Hurst R (2010) Selenium bioavailability: current knowledge and future research requirements. Am J Clin Nutr 91(5):1484S–1491SCrossRefPubMedGoogle Scholar
  23. 23.
    Forouhi NG et al (2007) Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study. Diabetologia 50(5):949–956CrossRefPubMedGoogle Scholar
  24. 24.
    Jiakui L, Xiaolong W (2004) Effect of dietary organic versus inorganic selenium in laying hens on the productivity, selenium distribution in egg and selenium content in blood, liver and kidney. J Trace Elem Med Biol 18(1):65–68CrossRefPubMedGoogle Scholar
  25. 25.
    Zhao L et al (2017) A novel organic selenium compound exerts unique regulation of selenium speciation, selenogenome, and selenoproteins in broiler chicks. J Nutr 147(5):789–797CrossRefPubMedGoogle Scholar
  26. 26.
    Zhang R et al (2016) Effects of selenium and cadmium on ion profiles in the brains of chickens. Biol Trace Elem Res 174(1):218–225CrossRefPubMedGoogle Scholar
  27. 27.
    Ma YL et al (2014) Effect of inorganic or organic selenium supplementation on reproductive performance and tissue trace mineral concentrations in gravid first-parity gilts, fetuses, and nursing piglets. J Anim Sci 92(12):5540–5550CrossRefPubMedGoogle Scholar
  28. 28.
    Kotyzová D et al (2010) Trace elements status in selenium-deficient rats—interaction with cadmium. Biol Trace Elem Res 136(3):287–293CrossRefPubMedGoogle Scholar
  29. 29.
    Li Y et al (2015) The concentration of selenium matters: a field study on mercury accumulation in rice by selenite treatment in qingzhen, Guizhou, China. Plant Soil 391(1–2):195–205CrossRefGoogle Scholar
  30. 30.
    Li Y et al (2012) Organic selenium supplementation increases mercury excretion and decreases oxidative damage in long-term mercury-exposed residents from Wanshan, China. Environmental Science & Technology 46(20):11313–11318CrossRefGoogle Scholar
  31. 31.
    Li X et al (2014) Dietary selenium protect against redox-mediated immune suppression induced by methylmercury exposure. Food Chem Toxicol 72:169–177CrossRefPubMedGoogle Scholar
  32. 32.
    Yoneda S et al (1997) Equimolar Hg-Se complex binds to selenoprotein P. Biochem Biophys Res Commun 231(1):7–11CrossRefPubMedGoogle Scholar
  33. 33.
    Aborode FA, Feldmann J (2016) The importance of glutathione and phytochelatins on the selenite and arsenate detoxification in Arabidopsis thaliana. J Environ Sci (China) 49:150–161CrossRefGoogle Scholar
  34. 34.
    Li YF et al (2010) Direct quantitative speciation of selenium in selenium-enriched yeast and yeast-based products by X-ray absorption spectroscopy confirmed by HPLC-ICP-MS. J Anal At Spectrom 25(3):426–430CrossRefGoogle Scholar
  35. 35.
    Al-Waeli A et al (2012) The role of selenium in cadmium toxicity: interactions with essential and toxic elements. Br Poult Sci 53(6):817–827CrossRefPubMedGoogle Scholar
  36. 36.
    Li X et al (2017) Effects of selenium-lead interaction on the gene expression of inflammatory factors and selenoproteins in chicken neutrophils. Ecotoxicol Environ Saf 139:447–453CrossRefPubMedGoogle Scholar
  37. 37.
    Yao H.D et al. (2013) Selenoprotein W serves as an antioxidant in chicken myoblasts. Biochim Biophys Acta 1830 (4): 3112–3120Google Scholar
  38. 38.
    Jin X et al (2017) The antagonistic effect of selenium on lead-induced apoptosis via mitochondrial dynamics pathway in the chicken kidney. Chemosphere 180:259–266CrossRefPubMedGoogle Scholar
  39. 39.
    Yao HD et al (2013) Gene expression of endoplasmic reticulum resident selenoproteins correlates with apoptosis in various muscles of se-deficient chicks. J Nutr 143(5):613–619CrossRefPubMedPubMedCentralGoogle Scholar
  40. 40.
    Wang Y (2009) Differential Effects of Sodium Selenite and Nano-Se on Growth Performance, Tissue Se Distribution, and Glutathione Peroxidase Activity of Avian Broiler. Biol Trace Elem Res 128(2):184–190CrossRefPubMedGoogle Scholar
  41. 41.
    Zhou X, Wang Y (2011) Influence of dietary nano elemental selenium on growth performance, tissue selenium distribution, meat quality, and glutathione peroxidase activity in Guangxi Yellow chicken. Poult Sci 90(3):680–686CrossRefPubMedGoogle Scholar
  42. 42.
    Xu SW et al (2013) The oxidative damage and disbalance of calcium homeostasis in brain of chicken induced by selenium deficiency. Biol Trace Elem Res 151(2):225–233CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Zhongkai University of Agriculture and EngineeringGuangzhouChina

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