Serum Selenium Levels and Cervical Cancer: Systematic Review and Meta-Analysis

Abstract

Several studies have investigated the relationship between serum Se concentration and cervical cancer, but the results were inconsistent. Thus, we conducted a systematic review and meta-analysis to evaluate the association between serum selenium levels and cervical cancer. Twelve studies investigating the association by univariate analysis and five studies by multivariate analysis were identified after a systematic search of PubMed, Wanfang, CNKI, and SinoMed databases. Standard mean differences (SMD) or odds ratios (OR) with the corresponding 95% confidence intervals (CI) were pooled to compare the selenium levels between different groups. In univariate analysis, serum selenium levels in cervical cancer cases were significantly lower than in controls (SMD = −4.86, 95% CI −6.03–3.69). Subgroup analysis showed consistent results. In multivariate analysis, serum selenium levels in cervical cancer cases were also significantly lower than in controls (OR = 0.55, 95% CI 0.42–0.73). After treatment, the serum selenium levels increased significantly (SMD = 2.59, 95% CI 0.50–4.69). In conclusion, high serum selenium levels were associated with cervical cancer, and selenium exposure might be a protective factor for cervical cancer.

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Correspondence to Dian Chen.

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The authors declare that they have no conflict of interest.

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Du He and Zaiping Wang contributed equally to this study.

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He, D., Wang, Z., Huang, C. et al. Serum Selenium Levels and Cervical Cancer: Systematic Review and Meta-Analysis. Biol Trace Elem Res 179, 195–202 (2017). https://doi.org/10.1007/s12011-017-0982-6

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Keywords

  • Selenium
  • Serum
  • Cervical cancer
  • Meta-analysis