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Cadmium Concentration in Human Autopsy Tissues

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Abstract

The concentration of cadmium in human tissues obtained on the basis of autopsies of non-poisoned Polish people (n = 150), aged from 1 to 80 years, examined between 1990 and 2010, is presented. The following values were found in wet digested samples by flame atomic absorption spectrometry (FAAS) (mean ± SD, median, and range, μg/g of wet weight): brain 0.020 ± 0.031, 0.084, 0–0.120 (n = 41); stomach 0.148 ± 0.195, 0.084, 0–1.25 (n = 89); small intestine 0.227 ± 0.231, 0.130, 0–0.830 (n = 39); liver 1.54 ± 1.55, 1.01, 0.015–9.65 (n = 99); kidney 16.0 ± 13.2, 14.0, 0.62–61.3 (n = 91); lung 0.304 ± 0.414, 0.130, 0–1.90 (n = 25); and heart 0.137 ± 0.107, 0.140, 0.017–0.250 (n = 4). Additionally, results (n = 13 people, aged from 2 to 83 years, 63 samples) obtained by inductively coupled plasma optical emission spectrometry (ICP OES) between 2010 and 2015 are given. The obtained data on Cd concentration in the human body can be used to estimate the amounts occurring in “healthy” people and those occurring in cases of chronic or acute poisonings with Cd compounds, which are examined for forensic purposes or to assess environmental exposure levels.

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References

  1. Maret W, Moulis JM (2013) The bioinorganic chemistry of cadmium in the context of its toxicity. Met Ions Life Sci 11:1–29

    Article  CAS  PubMed  Google Scholar 

  2. Nordberg GF, Nogawa K, Nordberg M, Friberg LT (2007) Chapter 23. Cadmium. In: Nordberg GF, Fowler BA, Nordberg M, Friberg LT (eds) Handbook on the toxicology of metals. Elsevier, AP, Amsterdam, pp 445–486

    Chapter  Google Scholar 

  3. dell’Omo M, Muzi G, Piccinini R, Gambelunghe A, Morucci P, Fiordi T, Ambrogi M, Abbritti G (1999) Blood cadmium concentrations in general population of Umbria, Central Italy. Sci Total Environ 226:57–64

    Article  PubMed  Google Scholar 

  4. Ōzden TA, Gökçay G, Ertem HV, Süoǧlu ŌD, Kılıç A, Sökücü S, Saner G (2007) Elevated hair levels of cadmium and lead in school children exposed to smoking and in highways near schools. Clin Biochem 40:52–56

    Article  PubMed  Google Scholar 

  5. Fuortes L, Leo A, Ellerbeck PG, Friell LA (1991) Acute respiratory fatality associated with exposure to sheet metal and cadmium fumes. J Toxicol Clin Toxicol 29:279–283

    Article  CAS  PubMed  Google Scholar 

  6. Enache A, Dressler ML, Taloş I, Lungu D, Cădariu F, Jebereanu C, Ciobanu V (2001) Some aspects of fatal cadmium poisoning. Rom J Leg Med 92:148–152

    Google Scholar 

  7. Hung Y-M, Chung H-M (2004) Acute self-poisoning by ingestion of cadmium and barium. Nephrol Dial Transplant 19:1308–1309

    Article  PubMed  Google Scholar 

  8. Eum KD, Lee MS, Paek D (2008) Cadmium in blood and hypertension. Sci Total Environ 407:147–153

    Article  CAS  PubMed  Google Scholar 

  9. Menke A, Muntner P, Silbergeld EK, Platz EA, Guallar E (2009) Cadmium levels in urine and mortality among U.S. adults. Environ Health Perspect 117:190–196

    Article  CAS  PubMed  Google Scholar 

  10. Lech T, Sadlik JK (2011) Zinc in postmortem body tissues and fluids. Biol Trace Elem Res 142:11–17

    Article  CAS  PubMed  Google Scholar 

  11. Lech T, Dudek-Adamska D (2009) The influence of the method of digestion of biological samples and the method of determination of some major and trace elements in these samples on analytical results. Problems of Forensic Sciences 80:429–440

    CAS  Google Scholar 

  12. Lech T, Lachowicz T (2009) Application of ICP-OES to multielement analysis of biological material in forensic inorganic toxicology. Problems of Forensic Sciences 77:64–78

    CAS  Google Scholar 

  13. Markiewicz J, Kobylecka K, Lech T, Sadlik J, Chłobowska Z (1992) The concentration of lead, cadmium, zinc and copper in liver and kidneys of the inhabitants of southern part of Poland. Z Zagadnień Kryminalistyki 26:28–33

    Google Scholar 

  14. Bem EM, Piotrowski JK, Turzyńska E (1993) Cadmium, zinc and copper levels in the kidneys and liver of the inhabitants of north-eastern Poland. Pol J Occup Med Environ Health 6:133–141

    CAS  PubMed  Google Scholar 

  15. Caroli S, Alimonti A, Delle Femmine P, Petrucci F, Senofonte O, Violante N (1992) Role of inductively coupled plasma emission spectrometry in the assessment of reference values for trace elements in biological matrices. J Anal At Spectrom 7:859–864

    Article  CAS  Google Scholar 

  16. Rahil-Khazen R, Bolann BJ, Myking A et al (2002) Multi-element analysis of trace elements levels in human autopsy tissues by using inductively coupled plasma atomic emission spectrometry technique (ICP-AES). J Trace Elem Med Biol 16:15–25

    Article  CAS  PubMed  Google Scholar 

  17. You YC, Lee SK, Yang JY, In SW, Kim KW, Chung KC, Chung MG, Choung SY (2002) Organ distribution of heavy metals in autopsy material from normal Korean. J Health Sci 48:186–194

    Article  Google Scholar 

  18. Orłowski C, Piotrowski JK (2003) Biological levels of cadmium and zinc in the small intestine of non-occupationally exposed human subjects. Hum Exp Toxicol 22:57–63

    Article  PubMed  Google Scholar 

  19. Johansen P, Mulvad G, Pedersen HS, Hansen JC (2006) Accumulation of cadmium in livers and kidneys in Greenlanders. Sci Total Environ 372(1):58–63

    Article  CAS  PubMed  Google Scholar 

  20. Satarug S, Baker JR, Reilly PEB, Moore MR, Williams DJ (2002) Cadmium levels in the lung, liver, kidney cortex and urine samples from Australians without occupational exposure to metals. Arch Environ Health 57:69–77

    Article  CAS  PubMed  Google Scholar 

  21. Barregård L, Fabricius-Lagging E, Lundh T, Mölne J, Wallin M, Olausson M, Modigh C, Sallsten G (2010) Cadmium, mercury, and lead in kidney cortex of living kidney donors: impact of different exposure sources. Environ Res 110:47–54

    Article  PubMed  Google Scholar 

  22. Goullé J-P, Mahieu L, Anagnostides J-G, Bouige D, Saussereau E, Guerber M, Lacroix C (2010) ICP-MS metal distribution in tissues of deceased individuals. Ann Toxicol Anal 22:1–9

    Article  Google Scholar 

  23. Mari M, Nadal M, Schumacher M, Domingo JL (2014) Human exposure to metals: levels in autopsy tissues of individuals living near a hazardous waste incinerator. Biol Trace Elem Res 159:15–21

    Article  CAS  PubMed  Google Scholar 

  24. Bocio A, Nadal M, Garcia F, Domingo JL (2005) Monitoring metals in the population living in the vicinity of a hazardous waste incinerator. Biol Trace Elem Res 106:41–50

    Article  CAS  PubMed  Google Scholar 

  25. García F, Ortega A, Domingo JL, Corbella J (2001) Accumulation of metals in autopsy tissues of subjects living in Taragona county, Spain. J Environ Sci Health A36:1767–1786

    Article  Google Scholar 

  26. Beneš B, Jakubiec K, Šmid J, Spĕváčková V (2000) Determination of thirty-two elements in human autopsy tissues. Biol Trace Elem Res 75:195–203

    Article  PubMed  Google Scholar 

  27. Katoh Y, Sato T, Yamamoto Y (2002) Determination of multielement concentrations in normal human organs from the Japanese. Biol Trace Elem Res 90:57–70

    Article  CAS  PubMed  Google Scholar 

  28. Hayashi C, Koizumi N, Nishio H, Koizumi N, Ikeda M (2012) Cadmium and other metals in autopsy samples from a cadmium-polluted area and non-polluted control areas in Japan. Biol Trace Elem Res 145:10–22

    Article  CAS  PubMed  Google Scholar 

  29. Rubio C, Hernández C, Delgado FG, Suárez Solá ML, Weller DG, Gutiérrez ÁJ, Hardisson A (2009) Pb and Cd in autopsy tissues. Toxicol Lett 189S:S57–S273

    Google Scholar 

  30. Barregård L, Svalander C, Schütz A, Westberg G, Sällsten G, Blohmé I, Möllne J, Attman P-O, Haglind P (1999) Cadmium, mercury, and lead in kidney cortex of the general Swedish population: a study of biopsies from living kidney donors. Environ Health Persp 107:867–871

    Article  Google Scholar 

  31. Baron P, Schweinsberg F (1989) A literature review of concentrations of arsenic, lead, cadmium and mercury in body fluids and tissues for establishing normal values and detection of body burden. 4. Lead, summary of average values for As, Cd, Hg and literature references. Zentrabl Hyg Umweltmed 188(3–4):195–239

    CAS  Google Scholar 

  32. Cikrt M, Lepši P, Kasparova L, Nĕmecĕk R, Blaha K, Nerudova J, Bittnerova D, Tichy M (1990) The study of exposure to cadmium in the general population. I Autopsy studies Polish J Occup Med 3(2):177–184

    CAS  Google Scholar 

  33. Benedetti JL, Samuel O, Dewailly E, Gingras S, Lefebvre MA (1999) Levels of cadmium in kidney and liver tissues among a Canadian population. J Toxicol Environ Health A 56(3):145–163

    Article  CAS  PubMed  Google Scholar 

  34. Yimaz O (2001) Cadmium and lead levels in human liver and kidney samples obtained from Bursa Province. Int J Environ Health Res 12(2):181–185

    Article  Google Scholar 

  35. Hansen JC, Grөn P, Jespersen BA, Voigt J, Simonsen J, Dalgaard JB, Hansen E (1989) Cadmium exposure in Denmark. Based on analyses of liver and kidney tissues. Dan Med Bull 36(5):499–502

    CAS  PubMed  Google Scholar 

  36. Lyon TDB, Patriarca M, Howatson AG, Fleming PJ, Blair PS, Fell GS (2002) Age dependence of potentially toxic elements (Sb, Cd, Pb, Ag) in human liver tissue from paediatric subjects. J Environ Monit 4:1034–1039

    Article  CAS  PubMed  Google Scholar 

  37. Pääkkö P, Kokkonen P, Antila S, Kalliomäki PL (1989) Cadmium and chromium as markers of smoking in human lung tissue. Environ Res 49(2):197–207

    Article  PubMed  Google Scholar 

  38. Kollmeier H, Seemann J, Wittig P, Rothe G, Müller KM (1990) Cadmium in human lung tissue. Int Arch Occup Environ Health 62(5):373–377

    Article  CAS  PubMed  Google Scholar 

  39. Sabbioni E, Nicolau GR, Pietra R, Beccaloni E, Coni E, Alimonti A, Caroli S (1990) Inductively coupled atomic emission spectrometry and neutron activation analysis for the determination of element reference values in human lung tissue. Biol Trace Elem Res 26–27:757–768

    Article  PubMed  Google Scholar 

  40. Drasch G, Müller RK, Grasemann F, Adang M, Roider G, Wowra D (1994) Comparison of the body burden of the population in the region of Leipzig and Munich with the heavy metals cadmium, lead and mercury—a study of human organ samples. Gesundheitswesen 56(5):263–267

    CAS  PubMed  Google Scholar 

  41. Thürauf J, Schaller KH, Valentin H, Weltie D, Grote K, Schellmann B (1986) Cadmium concentrations in autopsy material from differently polluted areas of West Germany. Zentralbl Bakteriol Mikrobiol Hyg B 182(4):337–347

    PubMed  Google Scholar 

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  1. Institute of Forensic Research, Westerplatte 9, 31-033, Krakow, Poland

    Teresa Lech & Józefa K. Sadlik

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  1. Teresa Lech
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Correspondence to Teresa Lech.

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Lech, T., Sadlik, J.K. Cadmium Concentration in Human Autopsy Tissues. Biol Trace Elem Res 179, 172–177 (2017). https://doi.org/10.1007/s12011-017-0959-5

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