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Comparative Analysis on the Effect of Plantago Species Aqueous Extracts on Tissue Trace Element Content in Rats

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Abstract

The primary objective of this study is to assess the influence of water extracts of Plantago major L., Plantago lanceolata L., and Plantago maxima Juss. ex Jacq. leaves on tissue trace element content in healthy adult Wistar rats. Twenty-eight female Wistar rats consumed pure drinking water or one of the three aqueous extracts of Plantago for 1 month. The extracts and liver, serum, hair, and adipose tissue of the rats were examined for trace element contents using inductively coupled plasma mass spectrometry. The aqueous extracts of Plantago species contained significant levels of trace elements, which were highest in P. lanceolata and P. major. The administration of every extract led to an increase in V and Si levels in the rats. At the same time, the consumption of P. lanceolata aqueous extract resulted in the accumulation of toxic elements (As, Pb) in the rats’ tissues. Despite the rather high concentration of heavy metals in the P. major leaf extract, its administration did not result in the accumulation of these elements. In turn, P. maxima extract induced a significant decrease in the tissue levels of Al, Cr, I, Li, and Mn in the rats. The beneficial effect of the P. major and P. maxima preparations may be at least partially associated with the increased supply of essential trace elements, whereas the use of P. lanceolata may be harmful due to the possibility of heavy metal overexposure.

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Authors and Affiliations

  1. Orenburg State Medical University, Sovetskaya St., 6, Orenburg, 460000, Russia

    Evgenia R. Gatiatulina, Olga N. Nemereshina, Alexandr A. Nikonorov & Alexey A. Tinkov

  2. South Ural State Medical University, Vorovskogo St., 64, Chelyabinsk, 454048, Russia

    Evgenia R. Gatiatulina

  3. Poznan University of Life Sciences, Wojska Polskiego St.28, Poznan, Poland

    Joanna Suliburska

  4. School of Energy and Environment, Thapar University, Patiala, 147004, India

    Tejo Prakash Nagaraja

  5. Lomonosov Moscow State University, Lomonosovsky Prospekt, 31-5, Moscow, 117192, Russia

    Anastasia A. Skalnaya

  6. Orenburg State University, Pobedy Avenue, 13, 460018, Orenburg, Russia

    Alexandr A. Nikonorov, Anatoly V. Skalny & Alexey A. Tinkov

  7. RUDN University, Miklukho-Maklay St., 10/2, Moscow, 117198, Russia

    Anatoly V. Skalny & Alexey A. Tinkov

  8. Yaroslavl State University, Sovetskaya St., 14, Yaroslavl, 150000, Russia

    Anatoly V. Skalny & Alexey A. Tinkov

  9. All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Grina St., 7, Moscow, 117216, Russia

    Anatoly V. Skalny

Authors
  1. Evgenia R. Gatiatulina
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  2. Olga N. Nemereshina
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  3. Joanna Suliburska
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  4. Tejo Prakash Nagaraja
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  5. Anastasia A. Skalnaya
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  6. Alexandr A. Nikonorov
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  7. Anatoly V. Skalny
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  8. Alexey A. Tinkov
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Corresponding author

Correspondence to Alexey A. Tinkov.

Ethics declarations

The investigation protocol was approved by the local ethics committee. All animal studies were performed in accordance with the ethical standards laid down in the US guidelines (NIH Publication no. 85-23, amended in 1985).

Conflict of Interest

The authors declare that they have no conflict of interest.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Gatiatulina, E.R., Nemereshina, O.N., Suliburska, J. et al. Comparative Analysis on the Effect of Plantago Species Aqueous Extracts on Tissue Trace Element Content in Rats. Biol Trace Elem Res 179, 79–90 (2017). https://doi.org/10.1007/s12011-017-0940-3

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  • DOI: https://doi.org/10.1007/s12011-017-0940-3

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