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Selenium Administration Alleviates Toxicity of Chromium(VI) in the Chicken Brain

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Abstract

Selenium (Se) can play a protective role against heavy metal toxicity. This experiment aims to evaluate the effect of Se supplementation at different doses on the chicken brains. Oxidative stress was induced in the chicken brains by chromium(VI). A total of 105 Hyland brown male chickens were randomly divided into seven groups, including the control group, poisoned group [6%LD50 K2Cr2O7 body weight (B.W.)], and detoxification groups K2Cr2O7 (6%LD50) + Se (0.31, 0.63, 1.25, 2.50, and 5.00 Na2SeO3 mg/kg B.W.) orally in water for 42 days. The chickens were detected by the activities of mitochondrial membrane potential, 2′-benzoyloxycinnamaldehyde, superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), and Ca2+-ATPase. Cr(VI) administration caused histopathological damage. In addition, changes in oxidative stress indicators were observed in the chicken’s brains. Se supplement increased the levels of GSH, mitochondrial membrane potential (MMP), and Ca2+-ATPase and reduced MDA activity in the detoxification groups. However, the high-dose Se supplementation groups of 2.50 and 5.00 mg/kg reduced the activities of GSH, MMP, and Ca2+-ATPase; increased the brain–body ratio; and increased SOD activity. In conclusion, Cr(VI) exposure caused oxidative stress. Se exerted a remission effect on toxic responses in the chicken brains. However, a high Se concentration was synergistic to the toxic effect of Cr(VI).

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Acknowledgements

This work was supported by the National Key R&D Program (2016YFD0501208), the Shandong Modern Agricultural Technology & Industry System (No. SDAIT-11-04).

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Authors and Affiliations

  1. College of Veterinary Medicine, Shandong Agricultural University, Tai’an, 271018, People’s Republic of China

    Pan Hao, Yiran Zhu, Shenghua Wang, Huiyu Wan, Peng Chen, Yang Wang, Ziqiang Cheng & Yongxia Liu

  2. Research Center for Animal Disease Control Engineering Shandong Province, Shandong Agricultural University, Tai’an, 271018, People’s Republic of China

    Jianzhu Liu

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  1. Pan Hao
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  2. Yiran Zhu
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  3. Shenghua Wang
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  4. Huiyu Wan
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  5. Peng Chen
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  6. Yang Wang
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  7. Ziqiang Cheng
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  8. Yongxia Liu
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  9. Jianzhu Liu
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Correspondence to Yongxia Liu or Jianzhu Liu.

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Pan Hao and Yiran Zhu contributed equally to this work.

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Hao, P., Zhu, Y., Wang, S. et al. Selenium Administration Alleviates Toxicity of Chromium(VI) in the Chicken Brain. Biol Trace Elem Res 178, 127–135 (2017). https://doi.org/10.1007/s12011-016-0915-9

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  • DOI: https://doi.org/10.1007/s12011-016-0915-9

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