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Selenium Deficiency-Induced Inflammation and Increased Expression of Regulating Inflammatory Cytokines in the Chicken Gastrointestinal Tract

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Abstract

Selenium (Se), a nutritionally essential trace element, plays an important role in various aspects of health for a wide range of species, including birds. Se deficiency inhibits the growth of immune organs and decreases immune function, leading to many inflammatory diseases. The present study determined the effects and mechanism of dietary Se deficiency on gastrointestinal tract tissue inflammation. The histopathological changes showed that Se deficiency induced inflammatory lesions in the gastrointestinal tract tissues (glandular stomach, gizzard, duodenum, small intestine, and rectum). The expression levels of PTGE (prostagland E synthase), COX-2 (cyclooxygenase-2), TNF-α (tumor necrosis factor α), and NF-κB (nuclear transfer factor κB) in the gastrointestinal tract tissues (glandular stomach, gizzard, duodenum, small intestine, and rectum) were determined by qPCR on days 15, 25, 35, 45, and 55, respectively. The results showed that Se deficiency induced high expression levels of PTGE, COX-2, TNF-α, and NF-κB in the gastrointestinal tract tissues. The effects were more obvious in the duodenum and small intestine than those in the glandular stomach, gizzard, and rectum. In addition, the expression levels of these proteins in the gastrointestinal tract tissue increased in a time-dependent manner with Se deficiency feeding time. Furthermore, Se deficiency induced the production of pro-inflammatory factors, thus aggravating inflammatory lesions in the gastrointestinal tract. The effect of Se deficiency on inflammation and other gastrointestinal tract diseases should be further studied.

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Acknowledgments

This study was supported by the National Natural Science Foundation of China (31272626) and the international (Regional) Cooperation and Exchange Projects of the National Natural Science Foundation of China (31320103920).

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Authors and Affiliations

  1. Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province, 130062, People’s Republic of China

    Xuejiao Gao & Naisheng Zhang

  2. College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Harbin, Hei Longjiang, 150030, People’s Republic of China

    Ziwei Zhang, Houjuan Xing & Shiwen Xu

  3. College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People’s Republic of China

    Jiao Yu

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  1. Xuejiao Gao
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  2. Ziwei Zhang
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Correspondence to Naisheng Zhang or Shiwen Xu.

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Gao, X., Zhang, Z., Xing, H. et al. Selenium Deficiency-Induced Inflammation and Increased Expression of Regulating Inflammatory Cytokines in the Chicken Gastrointestinal Tract. Biol Trace Elem Res 173, 210–218 (2016). https://doi.org/10.1007/s12011-016-0651-1

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