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Effects of Zinc Supplementation on Endocrine Outcomes in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial

Biological Trace Element Research volume 170, pages 271–278 (2016)Cite this article

28 February 2020 The Editors-in-Chief are currently investigating this article [Jamilian, M., Foroozanfard, F., Bahmani, F. et al. Effects of Zinc Supplementation on Endocrine Outcomes in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial. Biol Trace Elem Res 170, 271–278 (2016). https://doi.org/10.1007/s12011-015-0480-7] as concerns have been raised about integrity of the clinical trial reported here. There is also an ongoing investigation by the Iranian National Committee for Ethics in Biomedical Researches. Further editorial action will be taken as appropriate once the investigation into the concerns is complete and all parties have been given an opportunity to respond in full.

Abstract

The current study was conducted to evaluate the effects of zinc supplementation on endocrine outcomes, biomarkers of inflammation, and oxidative stress in patients with polycystic ovary syndrome (PCOS). This study was a randomized double-blind, placebo-controlled trial. Forty-eight women (18–40 years) with PCOS diagnosed according to Rotterdam criteria were randomly assigned to receive either 220 mg zinc sulfate (containing 50 mg zinc) (group 1; n = 24) and/or placebo (group 2; n = 24) for 8 weeks. Hormonal profiles, biomarkers of inflammation, and oxidative stress were measured at study baseline and after 8-week intervention. After 8 weeks of intervention, alopecia (41.7 vs. 12.5 %, P = 0.02) decreased compared with the placebo. Additionally, patients who received zinc supplements had significantly decreased hirsutism (modified Ferriman-Gallwey scores) (−1.71 ± 0.99 vs. −0.29 ± 0.95, P < 0.001) and plasma malondialdehyde (MDA) levels (−0.09 ± 1.31 vs. +2.34 ± 5.53 μmol/L, P = 0.04) compared with the placebo. A trend toward a significant effect of zinc intake on reducing high-sensitivity C-reactive protein (hs-CRP) levels (P = 0.06) was also observed. We did observe no significant changes of zinc supplementation on hormonal profiles, inflammatory cytokines, and other biomarkers of oxidative stress. In conclusion, using 50 mg/day elemental zinc for 8 weeks among PCOS women had beneficial effects on alopecia, hirsutism, and plasma MDA levels; however, it did not affect hormonal profiles, inflammatory cytokines, and other biomarkers of oxidative stress.

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Change history

  • 28 February 2020

    The Editors-in-Chief are currently investigating this article [Jamilian, M., Foroozanfard, F., Bahmani, F. et al. Effects of Zinc Supplementation on Endocrine Outcomes in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial. Biol Trace Elem Res 170, 271–278 (2016). https://doi.org/10.1007/s12011-015-0480-7] as concerns have been raised about integrity of the clinical trial reported here. There is also an ongoing investigation by the Iranian National Committee for Ethics in Biomedical Researches. Further editorial action will be taken as appropriate once the investigation into the concerns is complete and all parties have been given an opportunity to respond in full.

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Acknowledgments

The current study was supported by a grant from the Vice-chancellor for Research, AUMS, and Iran. The authors would like to thank the staff of Kosar Clinic (Arak, Iran) for their assistance in this project.

Conflict of Interest

The authors declare that they have no competing interests.

Authors’ Contributions

Z.A. contributed in the conception, design, statistical analysis, and drafting of the manuscript. M.J., F.F., F.B., R.T., and M.M. contributed in data collection and manuscript drafting. Z.A. supervised the study. All authors approved the final version for submission.

Funding

The study was supported by a grant (no. 93164) from Arak University of Medical Sciences.

Author information

Authors and Affiliations

  1. Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Islamic Republic of Iran

    Mehri Jamilian

  2. Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran

    Fatemeh Foroozanfard

  3. Department of Dermatology, School of Medicine, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran

    Rezvan Talaee

  4. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran

    Fereshteh Bahmani, Mahshid Monavari & Zatollah Asemi

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  1. Mehri Jamilian
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  2. Fatemeh Foroozanfard
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  3. Fereshteh Bahmani
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  4. Rezvan Talaee
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  6. Zatollah Asemi
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Corresponding author

Correspondence to Zatollah Asemi.

Additional information

Clinical trial registration number: www.irct.ir: IRCT201407115623N24

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Jamilian, M., Foroozanfard, F., Bahmani, F. et al. Effects of Zinc Supplementation on Endocrine Outcomes in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial. Biol Trace Elem Res 170, 271–278 (2016). https://doi.org/10.1007/s12011-015-0480-7

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  • DOI: https://doi.org/10.1007/s12011-015-0480-7

Keywords

  • Zinc
  • Supplementation
  • Polycystic ovary syndrome
  • Reproductive outcomes
  • Inflammation
  • Oxidative stress