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Biological Trace Element Research

, Volume 168, Issue 1, pp 206–220 | Cite as

Curcumin Ameliorates Lead (Pb2+)-Induced Hemato-Biochemical Alterations and Renal Oxidative Damage in a Rat Model

  • Ashraf M. Abdel-MoneimEmail author
  • Mona Y. El-Toweissy
  • Awatef M. Ali
  • Abd Allah M. Awad Allah
  • Hanaa S. Darwish
  • Ismail A. Sadek
Article

Abstract

This study aims to evaluate the protective role of curcumin (Curc) against hematological and biochemical changes, as well as renal pathologies induced by lead acetate [Pb (CH3COO)2·3H2O] treatment. Male albino rats were intraperitoneally treated with Pb2+ (25 mg of lead acetate/kg b.w., once a day) alone or in combination with Curc (30 mg of Curc/kg b.w., twice a day) for 7 days. Exposure of rats to Pb2+ caused significant decreases in hemoglobin (Hb) content, hematocrit (Ht) value, and platelet (Plt) count, while Pb2+-related leukocytosis was accompanied by absolute neutrophilia, monocytosis, lymphopenia, and eosinopenia. A significant rise in lipid peroxidation (LPO) and a marked drop of total antioxidant capacity (TAC) were evident in the kidney, liver, and serum of Pb2+ group compared to that of control. Furthermore, significantly high levels of total cholesterol (TC), triglycerides (TGs), and low-density lipoprotein cholesterol (LDL-C), and a sharp drop in serum high-density lipoprotein (HDL-C) level were also seen in blood after injection of Pb2+. Additionally, hepatorenal function tests were enhanced. Meanwhile, Pb2+ produced marked histo-cytological alterations in the renal cortex. Co-administration of Curc to the Pb2+-treated animals restored most of the parameters mentioned above to near-normal levels/features. In conclusion, Curc appeared to be a promising agent for protection against Pb2+-induced toxicity.

Keywords

Curcumin Lead acetate Hematotoxicity Hyperlipidemia Oxidative stress Nephrotoxicity 

Supplementary material

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Fig. 1S (DOCX 1004 kb)
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Fig. 2S (DOCX 496 kb)
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Fig. 3S (DOCX 1689 kb)

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Ashraf M. Abdel-Moneim
    • 1
    • 2
    Email author
  • Mona Y. El-Toweissy
    • 2
    • 3
  • Awatef M. Ali
    • 2
  • Abd Allah M. Awad Allah
    • 4
  • Hanaa S. Darwish
    • 4
  • Ismail A. Sadek
    • 2
  1. 1.Department of Biological Sciences, Faculty of ScienceKing Faisal UniversityAl-HassaSaudi Arabia
  2. 2.Department of Zoology, Faculty of ScienceAlexandria UniversityAlexandriaEgypt
  3. 3.Preparatory Year ProgramKing Faisal UniversityAl-HassaSaudi Arabia
  4. 4.Biology and Geology Department, Faculty of EducationAlexandria UniversityAlexandriaEgypt

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