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The Role of Oxidative Stress in Gastrointestinal Tract Tissues Induced by Arsenic Toxicity in Cocks

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Abstract

Arsenic (As) is a widely distributed trace element which is known to be associated with numerous adverse effects on human beings and animals. Arsenic trioxide (As2O3) is an inorganic arsenical-containing toxic compound. The effect of excessive amounts of As2O3 exposure on gastrointestinal tract tissue damage in cocks is still unknown. This study was conducted to investigate the effect of As2O3 exposure on gastrointestinal tract tissue damage in cocks. In total, 72 1-day-old male Hyline cocks were randomly divided into four groups and fed either a commercial diet or an As2O3 supplement diet containing 7.5, 15, and 30 mg/kg As2O3. The experiment lasted for 90 days and gastrointestinal tract tissue samples (gizzard, glandular stomach, duodenum, jejunum, ileum, cecum, and rectum) were collected at 30, 60, and 90 days. Catalase (CAT), glutathione (GSH), and glutathione peroxidase (GSH-Px) activities; malondialdehyde (MDA) contents; and hydroxyl radical (OH·)-mediated inhibition were examined. Furthermore, the results demonstrated that MDA content in the gastrointestinal tract was increased, while the activities of CAT, GSH, and GSH-Px and the ability to resist OH· was decreased in the As2O3 treatment groups. Extensive damage was observed in the gastrointestinal tract. These findings indicated that As2O3 exposure caused oxidative damage in the gastrointestinal tract of cocks due to alterations in antioxidant enzyme activities and elevation of free radicals.

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Acknowledgments

This study was supported by the Postdoctoral Scientific Research Developmental Foundation of Heilongjiang Province (Grant No. LBH-Q13012). We thank American Journal Experts for assistance with this manuscript.

Conflict of Interest

None of the authors has any financial or personal relationships that could inappropriately influence or bias the content of the paper.

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    Authors and Affiliations

    1. College of Wildlife Resources, Northeast Forestry University, Harbin, 150040, Heilongjiang Province, China

      Ying Guo, Panpan Zhao, Guangyang Guo, Zhibo Hu, Li Tian, Kexin Zhang, Wen Zhang & Mingwei Xing

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    1. Ying Guo
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    2. Panpan Zhao
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    3. Guangyang Guo
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    7. Wen Zhang
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    8. Mingwei Xing
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    Correspondence to Wen Zhang or Mingwei Xing.

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    Ying Guo and Panpan Zhao contributed equally to this work.

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    Guo, Y., Zhao, P., Guo, G. et al. The Role of Oxidative Stress in Gastrointestinal Tract Tissues Induced by Arsenic Toxicity in Cocks. Biol Trace Elem Res 168, 490–499 (2015). https://doi.org/10.1007/s12011-015-0357-9

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    • DOI: https://doi.org/10.1007/s12011-015-0357-9

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