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Serum Iodine Is Increased in Subjects Having Budd–Chiari Syndrome

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Abstract

This study was performed to investigate the status of serum iodine concentration among the Budd–Chiari syndrome (BCS) patients and its effect on thyroid hormone. The study group serum specimens were collected from 233 BCS patients and 60 healthy people. Serum iodine was analyzed with the Sandell–Kolthoff method, and the ELISA method was used to detect thyroid function: TSH, T3, T4, FT3, and FT4. The serum iodine level of patients with BCS was 316.7 ± 256.8 μg/L, greatly higher than 76.3 ± 25.7 μg/L of serum iodine for control group (p < 0.001), but with no significant difference among different types of BCS. There were no statistically significant differences in thyroid hormone levels (TSH, T3, T4, FT3, and FT4) between people with BCS and control group, although the TSH level of BCS group is slightly higher than that of normal control group. This study demonstrates that iodine may be related to the pathogenesis of BCS and needs to be paid more attention.

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References

  1. Hoekstra J, Janssen HL (2008) Vascular liver disorders (I): diagnosis, treatment and prognosis of Budd–Chiari syndrome. Neth J Med 66:334–339

    CAS  PubMed  Google Scholar 

  2. Brancatelli G, Vilgrain V, Federle MP, Hakime A, Lagalla R, Iannaccone R, Valla D (2007) Budd–Chiari syndrome: spectrum of imaging findings. AJR Am J Roentgenol 188:168–176

    Article  Google Scholar 

  3. Bayraktar UD, Seren S, Bayraktar Y (2007) Hepatic venous outflow obstruction: three similar syndromes. World J Gastroenterol 13:1912–1927

    Article  PubMed Central  PubMed  Google Scholar 

  4. Lupescu IG, Dobromir C, Popa GA, Gheorghe L, Georgescu SA (2008) Spiral computed tomography and magnetic resonance angiography evaluation in Budd–Chiari syndrome. J Gastrointestin Liver Dis 17:223–226

    PubMed  Google Scholar 

  5. Qiao T, Liu CJ, Liu C, Chen K, Zhang XB, Zu MH (2005) Interventional endovascular treatment for Budd–Chiari syndrome with long-term follow-up. Swiss Med Wkly 135:318–326

    PubMed  Google Scholar 

  6. Zhuang Y, Zu M, Zhang Q (2011) Epidemiological investigation of 1148 patients with Budd–Chiari syndrome. Chin J Gen Surg 20:614–617

    Google Scholar 

  7. Uvaraj P, Rathisharmila R, Ilamaran V (2013) Protein C and protein S deficiency presenting as Budd–Chiari syndrome. Blood Coagul Fibrinolysis 24:652–654

    Article  PubMed  Google Scholar 

  8. Qi X, De Stefano V, Wang J, Bai M, Yang Z, Han G, Fan D (2013) Prevalence of inherited antithrombin, protein C, and protein S deficiencies in portal vein system thrombosis and Budd–Chiari syndrome: a systematic review and meta-analysis of observational studies. J Gastroenterol Hepatol 28:432–442

    Article  CAS  PubMed  Google Scholar 

  9. Boskovic A, Kitic I, Stankovic I, Prokic D, Zlatar N (2014) Primary Budd–Chiari syndrome in a 3-year-old boy with homozygous factor V Leiden G1691A mutation. Eur J Pediatr 173:393–395

    Article  PubMed  Google Scholar 

  10. Toyama K, Karasawa M, Yamane A, Koiso H, Yokohama A, Uchiumi H, Saitoh T, Handa H, Sato K, Takagi H, Miyawaki S, Murakami H, Nojima Y, Tsukamoto N (2009) Low burden of a JAK2-V617F mutated clone in monoclonal haematopoiesis in a Japanese woman with Budd–Chiari syndrome. Int J Hematol 89:517–522

    Article  CAS  PubMed  Google Scholar 

  11. Nakase H, Kawasaki T, Itani T, Mimura J, Komori H, Okazaki K, Chiba T (2001) Budd–Chiari syndrome and extrahepatic portal obstruction associated with congenital antithrombin III deficiency. J Gastroenterol 36:341–345

    Article  CAS  PubMed  Google Scholar 

  12. Pei-rui XIAO, Xin-ying LIN, Cheng-hao GUO (2011) Study of correlation between the geographical distributions of Budd–Chiari syndrome with iodine content in drinking water. J Clin Hepatol 27:130–133

    Google Scholar 

  13. Melse-Boonstra A, Mackenzie I (2013) Iodine deficiency, thyroid function and hearing deficit: a review. Nutr Res Rev 26:110–117

    Article  CAS  PubMed  Google Scholar 

  14. Lu X, Xu K, Zhang QQ, Yang C, Li SD, Li JS, Rong YT, Zhu MH (2011) Study on between magnetic resonance venography and digital subtraction angiography on the inferior vena cava obstructive interface morphology of Budd–Chiari syndrome. Zhonghua Gan Zang Bing Za Zhi 19:923–926

    PubMed  Google Scholar 

  15. Bunyamin B, Mine G, Mustafa G (2009) Iodine and magnesium levels in maternal and umbilical cord blood of preeclamptic and normal pregnant women. Biol Trace Elem Res 129:1–8

    Article  Google Scholar 

  16. Burgi H (2010) Iodine excess. Best Pract Res Clin Endocrinol Metab 24:107–115

    Article  PubMed  Google Scholar 

  17. Wang Y, Zhang H, Guo C, Fan Q (2008) Pathologic and etiologic studies of membrane obstruction of the inferior vena cava in Budd-Chiari syndrome. J Interv Radiol 17:500–502

    Google Scholar 

  18. Hua Q, Zu M, Teng F, Wei N, Hu L (2013) Research on the relationship between bFGF, FGFR2 and the fibroblast proliferation promoted by high density iodine. J Interv Radiol 22:1016–1020

    Google Scholar 

  19. Zhou H, Xu H, Zu M (2008) Relationship between the impact of blood flow, diaphragm movement and the pathogenesis of membranous obstruction of inferior vena cava. J Interv Radiol 17:729–733

    Google Scholar 

Download references

Acknowledgments

The study was supported by the grants from the Clinical Medical Science and Technology Project of Jiangsu Province (BL2012021, BL2012044) and in part by the Nature Science Fund for Colleges and Universities in Jiangsu Province (12KJD310007).

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Authors and Affiliations

  1. School of Medical Imaging, Xuzhou Medical College, 84 West Huai-hai Road, Xuzhou, 221004, China

    Yinping Zhuang, Jingjing Li, Yong Wang & Cuiping Han

  2. Department of Interventional Radiology, Affiliated Hospital of Xuzhou Medical College, 99 West Huai-hai Road, Xuzhou, 221004, China

    Maoheng Zu, Qingqiao Zhang, Wei Xu & Ning Wei

  3. Department of Radiology, Affiliated Hospital of Xuzhou Medical College, 99 West Huai-hai Road, Xuzhou, 221004, China

    Kai Xu

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  1. Yinping Zhuang
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  2. Maoheng Zu
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  3. Jingjing Li
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  4. Yong Wang
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  5. Cuiping Han
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  6. Qingqiao Zhang
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  7. Wei Xu
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  8. Ning Wei
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  9. Kai Xu
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Correspondence to Maoheng Zu or Kai Xu.

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Zhuang, Y., Zu, M., Li, J. et al. Serum Iodine Is Increased in Subjects Having Budd–Chiari Syndrome. Biol Trace Elem Res 168, 21–24 (2015). https://doi.org/10.1007/s12011-015-0343-2

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  • DOI: https://doi.org/10.1007/s12011-015-0343-2

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