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The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture

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Abstract

Chordae tendineae rupture process is associated with increased production of inflammatory and angiogenesis mediators in connective tissues, which contributes to chronic inflammation and pathogenesis of degenerative chordae. A few trace elements are known to possess antioxidant, anti-inflammatory, and antiangiogenic properties. Therefore, the aim of this study was to determine whether zinc, selenium, midkine (MK), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor-A (VEGF-A), platelet-derived growth factor-BB (PDGF-BB), and reduced glutathione (GSH) levels are associated with inflammation and angiogenesis processes in the context of a potential etiology causing aggravation of mitral regurgitation and/or ruptured chordae tendineae. Seventy-one subjects comprising 34 patients with mitral chordae tendineae rupture (MCTR) and 37 healthy controls diagnosed on the basis of their clinical profile and transthoracic echocardiography were included in this study. The levels of GSH, MK, selenium, and zinc were found to be lower in the patients group when compared to control group. There were no significant difference in plasma TNF-α, IL-1β, IL-6, IL-8, VEGF-A, and PDGF-BB levels between two groups. There were positive significant correlations between MK and GSH, MK, and selenium levels in patients with MCTR. According to our data in which selenium, zinc, MK, and GSH decreased in MCTR patients, inflammatory response, oxidative stress, and trace element levels may contribute to etiopathogenesis of mitral regurgitation and/or ruptured chordae tendineae.

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Acknowledgments

This work was supported by the Research Fund of the University of Sakarya (project number: 2013-08-06-011). Also, this study was partly presented at 5th International Congress on Cell Membranes and Oxidative Stress: Focus on Calcium Signaling and TRP Channels, Cell Membranes and Free Radical Research 6(1): pp 365–366, 9–12 Sep, Süleyman Demirel University, Isparta Turkey (2014) and Annual Meeting of the German Biophysicsal Society, p 88, 14–17 Sep, Lübeck University, Lübeck Germany (2014).

Conflict of Interest

The authors declare that they have no conflicts of interest related to the publication of this manuscript.

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Authors and Affiliations

  1. Department of Biophysics, Faculty of Medicine, Sakarya University, 54290, Sakarya, Turkey

    Birsen Aydemir & Selim Ogut

  2. Department of Cardiology, Faculty of Medicine, Sakarya University, 54290, Sakarya, Turkey

    Ramazan Akdemir & M. Bulent Vatan

  3. Department of Biochemistry, Faculty of Medicine, Sakarya University, 54290, Sakarya, Turkey

    F. Behice Cinemre

  4. Department of Internal Medicine, Faculty of Medicine, Sakarya University, 54290, Sakarya, Turkey

    Hakan Cinemre

  5. Department of Biophyscs, Faculty of Medicine, Namik Kemal University, 59100, Tekirdag, Turkey

    Ali Riza Kiziler

  6. Department of Biophyscs, Cerrahpasa Medical Faculty, İstanbul University, 34098, Istanbul, Turkey

    Nurten Bahtiyar

  7. Department of Pharmacology, Faculty of Medicine, Sakarya University, 54290, Sakarya, Turkey

    M. Emin Buyukokuroglu

  8. Department of Physiology, Faculty of Medicine, Sakarya University, 54290, Sakarya, Turkey

    Gonul Gurol

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  1. Birsen Aydemir
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Correspondence to Birsen Aydemir.

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Aydemir, B., Akdemir, R., Vatan, M.B. et al. The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture. Biol Trace Elem Res 167, 179–186 (2015). https://doi.org/10.1007/s12011-015-0307-6

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  • DOI: https://doi.org/10.1007/s12011-015-0307-6

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