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Concentration of Selected Metals in Whole Blood, Plasma, and Urine in Short Stature and Healthy Children

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Abstract

The short stature in children is defined as height below the third percentile from the mean for age and gender. This problem affects about 3 % of young people. More than 20,000 children in Poland have problems with short stature. There is not much information available in the literature on the study of metals in blood, plasma, and urine in children with short stature. The study was conducted on a group of 56 short stature Polish children and 35 healthy children. The content of metals was determined using high-performance ion chromatography and inductively coupled plasma mass spectrometry methods. The study revealed significant differences between the content of selected metals in body fluids between a short stature group and healthy children. There were significant differences in the Fe, Cu, and Ni concentrations between the groups with respect to the hormonal therapy. There were no significant differences between the groups with respect to the area where the children lived. The results showed no statistically significant differences between metal concentration and age, body weight, and height. The study demonstrated statistically significant differences between the content of metals in body fluids in short stature children compared with the healthy children. It seems that the difference in the concentration of certain elements may also be the result of growth hormone therapy and the interaction between various metals. Both the alterations in the content of metals and their mutual interactions may play an important role in the pathogenesis of short stature children.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Additional informed consent was obtained from all individual participants for whom identifying information is included in this article.

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Authors and Affiliations

  1. Department of Pediatric Endocrinology and Diabetology, Medical University of Lublin, Gębali 6, 20-093, Lublin, Poland

    Maria Klatka & Witold Kołłątaj

  2. Department of Analytical Chemistry, Medical University of Lublin, Chodźki 4A, 20-093, Lublin, Poland

    Anna Błażewicz & Ryszard Kocjan

  3. Department of Jaw Orthopedics, Medical University of Lublin, Karmelicka 7, 20-081, Lublin, Poland

    Małgorzata Partyka

  4. Department of Pediatric Neurology, Medical University of Lublin, Gębali 6, 20- 093, Lublin, Poland

    Ewa Zienkiewicz

Authors
  1. Maria Klatka
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  2. Anna Błażewicz
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  3. Małgorzata Partyka
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  4. Witold Kołłątaj
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  5. Ewa Zienkiewicz
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  6. Ryszard Kocjan
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Correspondence to Maria Klatka.

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Klatka, M., Błażewicz, A., Partyka, M. et al. Concentration of Selected Metals in Whole Blood, Plasma, and Urine in Short Stature and Healthy Children. Biol Trace Elem Res 166, 142–148 (2015). https://doi.org/10.1007/s12011-015-0262-2

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  • DOI: https://doi.org/10.1007/s12011-015-0262-2

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