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Thyroid Function and Serum Copper, Selenium, and Zinc in General U.S. Population

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Abstract

Association of the levels of serum selenium (Se), zinc (Zn), and copper (Cu) with thyroid function was assessed by analyzing data from National Health and Nutrition Examination Survey for the cycle 2011–2012. Thyroid function variables analyzed were as follows: thyroid-stimulating hormone (TSH), free and total triiodothyronine (FT3, TT3), free and total thyroxine (FT4, TT4), and thyroglobulin (TGN). Regression models with log-transformed values of thyroid hormones as independent variables and age, race/ethnicity, smoking and iodine sufficiency status, respondents’ education, and levels of Se, Zn, and Cu as dependent variables were fitted. For males, levels of Zn were associated with decreased levels of FT4 and TT4, and levels of Cu were associated with increased levels of FT4 and TT4. For females, levels of Cu were associated with increased levels of TT3 and TT4. Smoking was found to be associated with lower levels of TSH and higher levels of TGN in males. Smoking was found to be associated with lower levels of TT4 in females. Males had about 5–10 % higher levels of both Se and Zn, but as much as 20 % lower levels of Cu than females. Smoking was associated with lower levels of Zn, but higher levels of Cu in males.

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References

  1. Manna D, Roy G, Mugesh G (2013) Antithyroid drugs and their analogues: synthesis, structure, and mechanism of action. Acc Chem Res 46:2706–2715. doi:10.1021/ar4001229

    Article  CAS  PubMed  Google Scholar 

  2. Bernal J (2005) Thyroid hormones and brain development. Vitam Horm 71:95–122

    Article  CAS  PubMed  Google Scholar 

  3. Bernal J (2007) Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab 3:249–259

    Article  CAS  PubMed  Google Scholar 

  4. Bizzarro MJ, Gross I (2004) Effects of hormones on fetal lung development. Obstet Gynecol Clin N Am 31:949–961, xii

    Article  Google Scholar 

  5. Danzi S, Dubon P, Klein I (2005) Effect of serum triiodothyronine on regulation of cardiac gene expression: role of histone acetylation. Am J Physiol Heart Circ Physiol 289:H1506–H1511

    Article  CAS  PubMed  Google Scholar 

  6. Grover GJ, Mellstrom K, Malm J (2005) Development of the thyroid hormone receptor beta-subtype agonist KB-141: a strategy for body weight reduction and lipid lowering with minimal cardiac side effects. Cardiovasc Drug Rev 23:133–148

    Article  CAS  PubMed  Google Scholar 

  7. Lopez-Artiguez M, Camean A, Gonzalez G, Repetto M (1995) Metal accumulation in human kidney cortex: mutual interrelations and effect of human factors. Hum Exp Toxicol 14:335–340

    Article  CAS  PubMed  Google Scholar 

  8. Brzoska MM, Moniuszko-Jakoniuk J (2001) Interactions between cadmium and zinc in the organism. Food Chem Toxicol 39:967–980

    Article  CAS  PubMed  Google Scholar 

  9. Franklin NM, Stauber JL, Lim RP, Petocz P (2009) Toxicity of metal mixtures to a tropical freshwater alga (Chlorella sp.): the effect of interactions between copper, cadmium, and zinc on metal cell binding and uptake. Environ Toxicol Chem 21:2412–2422. doi:10.1002/etc.5620211121

    Article  Google Scholar 

  10. Liu Y, Huang H, Zeng J, Sun C (2013) Thyroid volume, goiter prevalence, and selenium levels in an iodine-sufficient area: a cross-sectional study. BMC Public Health 13:1153. doi:10.1186/1471-2458-13-1153

    Article  PubMed Central  PubMed  Google Scholar 

  11. Gupta S, Jaworska-Bieniek K, Lubinski J, Jakubowska A (2013) Can selenium be a modifier of cancer risk in CHEK2 mutation carriers? Mutagenesis 28:625–629. doi:10.1093/mutage/get050

    Article  CAS  PubMed  Google Scholar 

  12. Sah S, Vandenberg A, Smits J (2013) Treating chronic arsenic toxicity with high selenium lentil diets. Toxicol Appl Pharmacol 272:256–262. doi:10.1016/jtaap201306008

    Article  CAS  PubMed  Google Scholar 

  13. Zwolak I, Zaporowska H (2012) Selenium interactions and toxicity: a review: selenium interactions and toxicity. Cell Biol Toxicol 28:31–46. doi:10.1007/s10565-011-9203-9

    Article  CAS  PubMed  Google Scholar 

  14. Bülow Pedersen I, Knudsen N, Carlé A, Schomburg L, Köhrle J, Jørgensen T, Rasmussen LB, Ovesen L, Laurberg P (2013) Serum selenium is low in newly diagnosed Graves’ disease: a population-based study. Clin Endocrinol (Oxf) 79:584–590. doi:10.1111/cen12185

    Article  Google Scholar 

  15. Kandhro GA, Kazi TG, Sirajuddin KNF, Kazi N, Afridi HI, Baig JA, Shah AQ, Wadhwa SK, Khan S, Arain MB (2011) Effects of selenium supplementation on iodine and thyroid hormone status in a selected population with goitre in Pakistan. Clin Lab 57:575–585

    CAS  PubMed  Google Scholar 

  16. Rayman MP (2012) Selenium and human health. Lancet 379(9822):1256–1268. doi:10.1016/S0140-6736(11)61452-9

    Article  CAS  PubMed  Google Scholar 

  17. ATSDR (2003) Toxicological profile for selenium. http://www.atsdrcdcgov/toxprofiles/tp92-ppdf. Accessed 3 Feb 2014

  18. Suzuki H, Asakawa A, Li JB, Tsai M, Amitani H, Ohinata K, Komai M, Inui A (2011) Zinc as an appetite stimulator—the possible role of zinc in the progression of diseases such as cachexia and sarcopenia. Recent Patents Food Nutr Agric 3:226–231

    Article  CAS  Google Scholar 

  19. Taccioli C, Chen H, Jiang Y, Liu XP, Huang K, Smalley KJ, Farber JL, Croce CM, Fong LY (2012) Dietary zinc deficiency fuels esophageal cancer development by inducing a distinct inflammatory signature. Oncogene 31:4550–4558. doi:10.1038/onc2011592

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Black MM (1998) Zinc deficiency and child development. Am J Clin Nutr 68(2 Suppl):464S–469S

    CAS  PubMed Central  PubMed  Google Scholar 

  21. Oluboyo AO, Adijeh RU, Onyenekwe CC, Oluboyo BO, Mbaeri TC, Odiegwu CN, Chukwuma GO, Onwuasoanya UF (2012) Relationship between serum levels of testosterone, zinc and selenium in infertile males attending fertility clinic in Nnewi, south east Nigeria. Afr J Med Med Sci 41(Suppl):51–54

    PubMed  Google Scholar 

  22. Bhutta ZA, Bird SM, Black RE, Brown KH, Gardner JM, Hidayat A, Khatun F, Martorell R, Ninh NX, Penny ME, Rosado JL, Roy SK, Ruel M, Sazawal S, Shankar A (2000) Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials. Am J Clin Nutr 72:1516–1522

    CAS  PubMed  Google Scholar 

  23. Baltaci AK, Mogulkoc R, Belviranli M (2013) Serum levels of calcium, selenium, magnesium, phosphorus, chromium, copper and iron—their relation to zinc in rats with induced hypothyroidism. Acta Clin Croat 52:151–156

    PubMed  Google Scholar 

  24. Betsy A, Binitha M, Sarita S (2013) Zinc deficiency associated with hypothyroidism: an overlooked cause of severe alopecia. Int J Trichology 5:40–42. doi:10.4103/0974-7753114714

    Article  PubMed Central  PubMed  Google Scholar 

  25. Baltaci AK, Mogulkoc R, Belviranli M (2013) L-thyroxine-induced hyperthyroidism affects elements and zinc in rats. Bratisl Lek Listy 114:125–128

    CAS  PubMed  Google Scholar 

  26. Meeker JD, Rossano MG, Protas B, Diamond MP, Puscheck E, Daly D, Paneth N, Wirth JJ (2009) Multiple metals predict prolactin and thyrotropin (TSH) levels in men. Environ Res 109:869–873. doi:10.1016/jenvres200906004

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  27. Niskar AS, Paschal DC, Kieszak SM, Flegal KM, Bowman B, Gunter EW, Pirkle JL, Rubin C, Sampson EJ, McGeehin M (2003) Serum selenium levels in the US population: Third National Health and Nutrition Examination Survey, 1988-1994. Biol Trace Elem Res 91:1–10

    Article  CAS  PubMed  Google Scholar 

  28. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, Braverman LE (2002) Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 87:489–499

    Article  CAS  PubMed  Google Scholar 

  29. Kelly G (2000) Peripheral metabolism of thyroid hormones: a review. Altern Med Rev 5306:333

    Google Scholar 

  30. Blount BC, Pirkle JL, Osterloh JD, Valentin-Blasini L, Caldwell KL (2006) Urinary perchlorate and thyroid hormone levels in adolescent and adult men and women living in the United States. Environ Health Perspect 114:1865–1871

    CAS  PubMed Central  PubMed  Google Scholar 

  31. WHO (2007) Iodine deficiency in Europe: a continuing public health problem. Editors: Andersson, M; de Benoist, B; Darnton-Hill, I; Delange, F. http://wwww.hoint/nutrition/publications/VMNIS_Iodine_deficiency_in_Europepdf. Accessed 25 June 2013

  32. Rokadia HK, Agarwal S (2012) Serum cystatin C and emphysema: results from the National Health and Nutrition Examination Survey (NHANES). Lung 190:283–290. doi:10.1007/s00408-012-9374-z

    Article  CAS  PubMed  Google Scholar 

  33. Jain RB, Wang RY (2011) Association of caffeine consumption and smoking status with the serum concentrations of polychlorinated biphenyls, dioxins, and furans in the general US population: NHANES 2003-2004. J Toxicol Environ Health A 74:1225–1239

    Article  CAS  PubMed  Google Scholar 

  34. Jain RB (2013) Effect of smoking and caffeine consumption on polybrominated diphenyl ethers (PBDE) and polybrominated biphenyls (PBB). J Toxicol Environ Health A 76:515–532

    Article  CAS  PubMed  Google Scholar 

  35. Wasowicz W, Gromadzinska J, Szram K, Rydzynski K, Cieslak J, Pietrzak Z (2001) Selenium, zinc, and copper concentrations in the blood and milk of lactating women. Biol Trace Elem Res 79:221–233

    Article  CAS  PubMed  Google Scholar 

  36. Yanik M, Kocyigit A, Tutkun H, Vural H, Herken H (2004) Plasma manganese, selenium, zinc, copper, and iron concentrations in patients with schizophrenia. Biol Trace Elem Res 98:109–117

    Article  CAS  PubMed  Google Scholar 

  37. Agay D, Anderson RA, Sandre C, Bryden NA, Alonso A, Roussel AM, Chancerelle Y (2005) Alterations of antioxidant trace elements (Zn, Se, Cu) and related metallo-enzymes in plasma and tissues following burn injury in rats. Burns 31:366–371

    Article  CAS  PubMed  Google Scholar 

  38. Lin C, Huang J, Tsai L, Huang Y (2006) Selenium, iron, copper, and zinc levels and copper-to-zinc ratios in serum of patients at different stages of viral hepatic diseases. Biol Trace Elem Res 109:15–23

    Article  CAS  PubMed  Google Scholar 

  39. Jain RB (2013) Association between thyroid profile and perfluoroalkyl acids: Data from NHANES 2007-2008. Environ Res 126:51–59

    Article  CAS  PubMed  Google Scholar 

  40. Jain RB (2014) Association between thyroid function and selected organochlorine pesticides: data from NHANES 2001-2002. Sci Total Environ 466–467:706–715

    Article  PubMed  Google Scholar 

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Author declares that he had no financial or other conflicts that could have affected the conclusions arrived at in this communication.

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    Ram B. Jain

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Correspondence to Ram B. Jain.

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Authors did not receive any funding to conduct this research. All data used in this research are available free of charge from www.cdc.gov/nchs/nhanes.htm.

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Jain, R.B. Thyroid Function and Serum Copper, Selenium, and Zinc in General U.S. Population. Biol Trace Elem Res 159, 87–98 (2014). https://doi.org/10.1007/s12011-014-9992-9

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