Biological Trace Element Research

, Volume 159, Issue 1–3, pp 8–14 | Cite as

Association Between Serum Level of Magnesium and Postmenopausal Osteoporosis: A Meta-analysis

  • Jianmao Zheng
  • Xueli Mao
  • Junqi LingEmail author
  • Qun He
  • Jingjing Quan
  • Hongbo Jiang


There are conflicting reports as to the association between serum level of magnesium (Mg) and postmenopausal osteoporosis (OP). The purpose of the present study is to clarify the association between serum level of Mg and postmenopausal OP using a meta-analysis approach. We searched articles indexed in Pubmed and the Chinese Journal Full-text Database (CJFD) published as of October 2013 that met our predefined criteria. Seven eligible studies involving 1,349 postmenopausal women from 12 case-control study arms were identified. Overall, pooled analysis indicated that postmenopausal osteoporotic women had a lower serum level of Mg than the healthy controls (standardized mean difference [SMD] = −0.55, 95 % confidence interval [CI] = −0.83 to −0.26). Further subgroup analysis found a similar pattern in Turkey (SMD = −0.66, 95 % CI = −0.99 to −0.32) and Belgium (SMD = −0.98, 95 % CI = −1.91 to −0.05), but not in China (SMD = 0.02, 95 % CI = −0.21 to 0.26). And the difference of serum level of Mg between postmenopausal osteoporotic women and healthy controls below the age of 60 years (SMD = −0.61, 95 % CI = −1.09 to −0.13) was similar to that among the population over 60 years (SMD = −0.49, 95 % CI = −0.80 to −0.18).In conclusion, this meta-analysis suggests that the low serum level of Mg seems to be a risk factor for OP among the postmenopausal women. However, the subgroup analysis found that there was contradiction regarding races and geography, like China and Turkey. Thus, this finding needs further confirmation by trans-regional multicenter study to obtain better understanding of causal relationships between serum Mg and postmenopausal OP.


Serum magnesium Postmenopausal women Postmenopausal osteoporosis Meta-analysis 



The project was supported by the Guangzhou Municipal Science and Technology Project (11C32060748) and the National Natural Science Foundation of China (81100728).


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Jianmao Zheng
    • 1
  • Xueli Mao
    • 1
  • Junqi Ling
    • 1
    Email author
  • Qun He
    • 2
  • Jingjing Quan
    • 1
  • Hongbo Jiang
    • 3
  1. 1.Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Affiliated Stomatological HospitalSun Yat-sen UniversityGuangzhouChina
  2. 2.Guangdong Provincial Institute of Public Health, Center for Disease Prevention and Control of Guangdong ProvinceGuangzhouChina
  3. 3.Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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