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Zinc and Homocysteine Levels in Polycystic Ovarian Syndrome Patients with Insulin Resistance

Biological Trace Element Research volume 158, pages 297–304 (2014)Cite this article

Abstract

In this study, our objective was to evaluating the value of serum zinc levels as an etiologic and prognostic marker in patients with polycystic ovarian syndrome. We conducted a prospective study, including 53 women with polycystic ovarian syndrome and 33 healthy controls. We compared serum zinc levels, as well as clinical and metabolic features, of the cases. We also compared serum zinc levels between patients with polycystic ovarian syndrome with insulin resistance. Mean zinc levels were found to be significantly lower in patients with polycystic ovarian syndrome than healthy controls. Multiple logistic regression analysis of significant metabolic variables between polycystic ovarian syndrome and control groups (serum zinc level, body mass index, the ratio of triglyceride/high-density lipoprotein cholesterol, and homocysteine) revealed that zinc level was the most significant variable to predict polycystic ovarian syndrome. Mean serum zinc levels tended to be lower in patients with polycystic ovarian syndrome with impaired glucose tolerance than patients with normal glucose tolerance, but the difference was not statistically significant. In conclusion, zinc deficiency may play a role in the pathogenesis of polycystic ovarian syndrome and may be related with its long-term metabolic complications.

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Authors and Affiliations

  1. Department of Obstetrics & Gynecology, Faculty of Medicine, Gazi University, 06500 Besevler, Ankara, Turkey

    Ismail Guler, Ozdemir Himmetoglu, Ahmet Turp, Ahmet Erdem, Mehmet Erdem, M. Anıl Onan, Cagatay Taskiran & Haldun Guner

  2. Department of Biochemistry, Faculty of Medicine, Gazi University, Ankara, Turkey

    Mine Yavuz Taslipinar

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  1. Ismail Guler
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  2. Ozdemir Himmetoglu
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Guler, I., Himmetoglu, O., Turp, A. et al. Zinc and Homocysteine Levels in Polycystic Ovarian Syndrome Patients with Insulin Resistance. Biol Trace Elem Res 158, 297–304 (2014). https://doi.org/10.1007/s12011-014-9941-7

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  • DOI: https://doi.org/10.1007/s12011-014-9941-7

Keywords

  • Zinc
  • PCOS
  • Insulin resistance
  • Hyperinsulinism
  • Homocysteine
  • Metabolic syndrome