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Biological Trace Element Research

, Volume 164, Issue 1, pp 25–35 | Cite as

Differences Between Chemical Element Contents in Hyperplastic and Nonhyperplastic Prostate Glands Investigated by Neutron Activation Analysis

  • Vladimir ZaichickEmail author
  • Sofia Zaichick
  • German Davydov
Article
  • 139 Downloads

Abstract

In order to clarify the differences between Ag, Br, Ca, Co, Cr, Fe, Hg, K, Mg, Mn, Na, Rb, Sb, Sc, Se, and Zn contents in hyperplastic (patients with benign prostate hyperplasia (BPH), n = 32) and nonhyperplastic (control group of healthy male inhabitants, n = 32) prostates, an instrumental neutron activation analysis was performed. Mean values (M ± SΕΜ) for mass fraction (mg/kg, dry mass basis) of chemical elements in glands of patients with BPH were the following: Ag, 0.0346 ± 0.0060; Br, 30.4 ± 3.6; Ca, 2030 ± 165; Co, 0.0716 ± 0.0097; Cr, 1.073 ± 0.119; Fe, 130.0 ± 7.9; Hg, 0.232 ± 0.030; K, 14,470 ± 740; Mg, 1200 ± 80; Mn, 1.19 ± 0.09; Na, 11,610 ± 870; Rb, 14.7 ± 0.8; Sb, 0.163 ± 0.025; Sc, 0.0257 ± 0.0040; Se, 1.243 ± 0.079; and Zn, 1235 ± 92. It was observed that in BPH tissue, the mass fraction of Co (p < 0.015), Cr (p < 0.0002), Hg (p < 0.000007), K (p < 0.001), Rb (p < 0.048), Sb (p < 0.0001), and Se (p < 0.000001) were significantly higher than in controls. In the sixth to eighth decades, the mass fractions of almost all chemical elements in hyperplastic prostates did not depend from age. Our finding of correlation between pairs of prostatic chemical element mass fractions indicates that there is a great disturbance of prostatic chemical element relationships with a benign hyperplastic transformation. The results apparently confirm the disturbed homeostasis of Zn and Se and some other chemical elements in the etiology of BPH.

Keywords

Prostate BPH Chemical element contents Homeostasis of chemical elements 

Notes

Acknowledgments

The authors are grateful to the late Prof. A. A. Zhavoronkov, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, and Dr. Tatyana Sviridova, Medical Radiological Research Center, Obninsk, for supplying prostate specimens.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Vladimir Zaichick
    • 1
    Email author
  • Sofia Zaichick
    • 1
    • 2
  • German Davydov
    • 3
  1. 1.Radionuclide Diagnostics DepartmentMedical Radiological Research CentreObninskRussia
  2. 2.Department of MedicineUniversity of Illinois College of MedicineChicagoUSA
  3. 3.Radionuclide Diagnostics DepartmentMedical Radiological Research CentreObninskRussia

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