Abstract
The rare earth salts of heteropoly have been widely applied in many fields. In this study, the biological activity of rare earth tungstoarsenate heteropolyoxometalates K11[Ln(AsW11O39)2]·xH2O (abbr. LnW11, Ln = La (x = 24), Nd (x = 17), and Sm (x = 19)) were investigated by spectroscopic methods including fluorescence spectroscopy and UV–vis absorption spectroscopy at different temperatures. In the mechanism discussion, it was proved that the fluorescence quenching of bovine serum albumin (BSA) by LnW11 is initiated by complex formation. The thermodynamic parameters suggested that the binding of LnW11 to BSA is spontaneous, and the mainly force is electrostatic interactions. Site marker competitive experiments demonstrated that LaW11 binds with high affinity to site I (subdomain IIA) of BSA; but SmW11 and NdW11 bind with affinity to both site I (subdomain IIA) and site II (subdomain IIIA) of BSA. The results of synchronous fluorescence spectrum indicate that the secondary structure of BSA molecules was changed in the presence of LnW11. In addition, the binding parameters, binding site number, and effect of metal ions on LnW11–BSA were also discussed.
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Acknowledgments
This work was supported by the National Natural Science Foundation of China (No. 21273065), and the Research Foundation of Education Bureau of Hubei Province, China (Nos. B20132502, Q20122205).
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Jiang, S., Cheng, LY., Bai, AM. et al. Novel Rare Earth Tungstoarsenate Heteropolyoxometalates K11[Ln(AsW11O39)2]·xH2O (Ln = La, Nd, Sm) Binding to Bovine Serum Albumin: Spectroscopic Approach. Biol Trace Elem Res 163, 275–282 (2015). https://doi.org/10.1007/s12011-014-0183-5
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DOI: https://doi.org/10.1007/s12011-014-0183-5