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Malondialdehyde, Antioxidant Enzymes, and Renal Tubular Functions in Children with Iron Deficiency or Iron-Deficiency Anemia

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Abstract

We aimed to investigate the effects of iron deficiency (ID) or iron-deficiency anemia (IDA) on oxidative stress and renal tubular functions before and after treatment of children. A total of 30 children with a diagnosis of IDA constituted the IDA group and 32 children with a diagnosis of ID constituted the ID group. Control group consisted 38 age-matched children. Serum ferritin, soluble transferrin receptor (sTfR), serum, and urinary sodium (Na), potassium (K), calcium (Ca), phosphorus (P), creatinine (Cr), uric acid (UA), urinary N-acetyl-β-d-glucosaminidase (NAG) levels, and intra-erythrocyte malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) levels were measured before and after iron therapy in the IDA and ID groups, whereas it was studied once in the control group. We have divided the study group in groups according to age (infants <2 years, children 3–9 years, and adolescents 10–15 years). Patients with IDA (infant, adolescent) and ID (infant, children, and adolescent) had a significantly high level of MDA in post-treatment period in comparison to those of healthy control. Patients with IDA (children, adolescent) and ID (infant, children) had a significantly high level of pre-treatment GSH-Px than controls. Post-treatment SOD was lower in IDA (children and adolescent) groups than control and post-treatment CAT was lower in IDA and ID (adolescent) groups than control. These findings show that ferrous sulfate used in the treatment of ID or IDA could lead to oxidative stress; however, a marked deterioration of in proximal renal tubular functions was not seen.

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Authors’ Contributions

Demet Altun and Ahmet Emin Kurekci were the principal investigators and take primary responsibility for the paper. Orhan Gursel and Duygu Övunc Hacıhamdioglu recruited the patients. Ismail Kurt and Ahmet Aydin performed the laboratory work for this study. Ahmet Emin Kurekci and Okan Ozcan co-ordinated the research. Demet Altun and Orhan Gursel wrote the paper.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Pediatrics, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey

    Demet Altun

  2. Department of Pediatric Hematology, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey

    Ahmet Emin Kurekci, Orhan Gursel & Okan Ozcan

  3. Department of Pediatric Nephrology, Gulhane Military Medical Academy and Medical Faculty, Haydarpasa Training Hospital, 34668, Uskudar, Istanbul, Turkey

    Duygu Ovunc Hacıhamdioglu

  4. Department of Biochemisty, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey

    Ismail Kurt

  5. Department of Pharmaceutical Sciences, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey

    Ahmet Aydın

Authors
  1. Demet Altun
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  2. Ahmet Emin Kurekci
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  3. Orhan Gursel
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  4. Duygu Ovunc Hacıhamdioglu
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  5. Ismail Kurt
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  6. Ahmet Aydın
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  7. Okan Ozcan
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Correspondence to Duygu Ovunc Hacıhamdioglu.

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Altun, D., Kurekci, A.E., Gursel, O. et al. Malondialdehyde, Antioxidant Enzymes, and Renal Tubular Functions in Children with Iron Deficiency or Iron-Deficiency Anemia. Biol Trace Elem Res 161, 48–56 (2014). https://doi.org/10.1007/s12011-014-0084-7

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  • DOI: https://doi.org/10.1007/s12011-014-0084-7

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