Abstract
The primary objective of the current study was to estimate the hair toxic metal content in adults in relation to body mass index. A total of 1,229 persons including 719 women and 510 men were examined. All subjects were divided into two age groups: 1 and 2 periods of adulthood. All men and women were also subdivided into groups in relation to their values of body mass index (BMI): underweight, normal weight, overweight and obese. Hair aluminium (Al), beryllium (Be), cadmium (Cd), mercury (Hg), lead (Pb) and tin (Sn) content was evaluated using mass spectrometry with inductively coupled plasma. It has been shown that increase in body weight is accompanied by elevated hair cadmium content in women. At the same time, no significant alteration of hair cadmium concentration was observed in males. Higher values of scalp hair mercury and lead content were observed in men and women with increased body mass index independently of their age. BMI-related elevation of hair tin content was registered only in men of the first period of adulthood. A significant correlation between hair metal content and the values of BMI was observed for mercury independently of the gender of the subjects, whereas BMI values correlated significantly with hair cadmium levels in women and lead and tin levels in men. It has been also estimated that hair cadmium, mercury and lead levels in men exceed the respective values in women.
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World Health Organization (2014) Obesity and overweight. http://www.who.int/mediacentre/factsheets/fs311/en/. Accessed 14 May 2014
Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, Singh GM, Gutierrez HR, Lu Y, Bahalim AN, Farzadfar F, Riley LM, Ezzati M, Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index) (2011) National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants. Lancet 377(9765):557–567
Lidstone JS, Ells LJ, Finn P, Whittaker VJ, Wilkinson JR, Summerbell CD (2006) Independent associations between weight status and disability in adults: results from the Health Survey for England. Public Health 120(5):412–417
Tunceli K, Li K, Williams LK (2006) Long-term effects of obesity on employment and work limitations among U.S. Adults, 1986 to 1999. Obesity (Silver Spring) 14(9):1637–1646
Popkin BM, Kim S, Rusev ER, Du S, Zizza C (2006) Measuring the full economic costs of diet, physical activity and obesity-related chronic diseases. Obes Rev 7(3):271–293
Regnier SM, Sargis RM (2014) Adipocytes under assault: environmental disruption of adipose physiology. Biochim Biophys Acta 1842(3):520–533
Dyer CA (2007) Heavy metals as endocrine disrupting chemicals. In: Gore AC (ed) Endocrine-disrupting chemicals: from basic research to clinical practice. Humana, Totowa, pp 111–133
Iavicoli I, Fontana L, Bergamaschi A (2009) The effects of metals as endocrine disruptors. J Toxicol Environ Health B Crit Rev 12(3):206–223
Padilla MA, Elobeid M, Ruden DM, Allison DB (2010) An examination of the association of selected toxic metals with total and central obesity indices: NHANES 99-02. Int J Environ Res Public Health 7(9):3332–3347
Frolkis VV (1982) Handbook of physiology. Biology of aging. Nauka, Leningrad
World Health Organization (2014) Global database on body mass index. http://www.who.int/bmi/index.jsp?intropage=intro3_html. Accessed 14 May 2014
Park SB, Choi SW, Nam AY (2009) Hair tissue mineral analysis and metabolic syndrome. Biol Trace Elem Res 130(3):218–228
Skalnaya MG, Demidov VA (2007) Hair trace element contents in women with obesity and type 2 diabetes. J Trace Elem Med Biol 21(S1):59–61
He K, Xun P, Liu K, Morris S, Reis J, Guallar E (2013) Mercury exposure in young adulthood and incidence of diabetes later in life: the CARDIA Trace Element Study. Diabetes Care 36(6):1584–1589
Lee BK, Kim Y (2013) Blood cadmium, mercury, and lead and metabolic syndrome in South Korea: 2005–2010 Korean National Health and Nutrition Examination Survey. Am J Ind Med 56(6):682–692
Grün F, Blumberg B (2009) Endocrine disrupters as obesogens. Mol Cell Endocrinol 304(1–2):19–29
Grün F, Watanabe H, Zamanian Z, Maeda L, Arima K, Cubacha R, Gardiner DM, Kanno J, Iguchi T, Blumberg B (2006) Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates. Mol Endocrinol 20(9):2141–2155
Zuo Z, Chen S, Wu T, Zhang J, Su Y, Chen Y, Wang C (2011) Tributyltin causes obesity and hepatic steatosis in male mice. Environ Toxicol 26(1):79–85
Thayer KA, Heindel JJ, Bucher JR, Gallo MA (2012) Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop review. Environ Health Perspect 120(6):779–789
Kim R, Hu H, Rotnitzky A, Bellinger D, Needleman H (1995) A longitudinal study of chronic lead exposure and physical growth in Boston children. Environ Health Perspect 103(10):952–957
Clarkson TW (2002) The three modern faces of mercury. Environ Health Perspect 110(S1):11–23
Zalups RK, Ahmad S (2003) Molecular handling of cadmium in transporting epithelia. Toxicol Appl Pharmacol 186(3):163–188
DeMichele SJ (1984) Nutrition of lead. Comp Biochem Physiol A Comp Physiol 78(3):401–408
Appel KE (2004) Organotin compounds: toxicokinetic aspects. Drug Metab Rev 36(3–4):763–786
Geier A, Dietrich CG, Grote T, Beuers U, Prüfer T, Fraunberger P, Matern S, Gartung C, Gerbes AL, Bilzer M (2005) Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat. J Hepatol 43(6):1021–1030
Pizarro M, Balasubramaniyan N, Solís N, Solar A, Duarte I, Miquel JF, Suchy FJ, Trauner M, Accatino L, Ananthanarayanan M, Arrese M (2004) Bile secretory function in the obese Zucker rat: evidence of cholestasis and altered canalicular transport function. Gut 53(12):1837–1843
Cuvin-Aralar ML, Furness RW (1991) Mercury and selenium interaction: a review. Ecotoxicol Environ Saf 21(3):348–364
Yang D-Y, Chen Y-W, Gunn JM, Belzile N (2008) Selenium and mercury in organisms: interactions and mechanisms. Environ Rev 16:71–92
Kudo N, Nakagawa Y, Waku K, Kawashima Y, Kozuka H (1991) Prevention by zinc of cadmium inhibition of stearoyl-CoA desaturase in rat liver. Toxicology 68(2):133–142
Brzóska MM, Moniuszko-Jakoniuk J (2001) Interactions between cadmium and zinc in the organism. Food Chem Toxicol 39(10):967–980
Matović V, Plamenac Bulat Z, Djukić-Cosić D, Soldatović D (2010) Antagonism between cadmium and magnesium: a possible role of magnesium in therapy of cadmium intoxication. Magnes Res 23(1):19–26
Barbosa AC, Jardim W, Dórea JG, Fosberg B, Souza J (2001) Hair mercury speciation as a function of gender, age, and body mass index in inhabitants of the Negro River basin, Amazon, Brazil. Arch Environ Contam Toxicol 40(3):439–444
Staessen J, Yeoman WB, Fletcher AE, Markowe HL, Marmot MG, Rose G, Semmence A, Shipley MJ, Bulpitt CJ (1990) Blood lead concentration, renal function, and blood pressure in London civil servants. Br J Ind Med 47(7):442–447
Lee M, Park S, Hu H, Lee S (2011) Cadmium exposure and cardiovascular disease in the 2005 Korea National Health and Nutrition Examination Survey. Environ Res 111:171–176
Satarug S, Ujjin P, Vanavanitkun Y, Baker JR, Moore MR (2004) Influence of body iron store status and cigarette smoking on cadmium body burden of healthy Thai women and men. Toxicol Lett 148(3):177–185
Olsson IM, Bensryd I, Lundh T, Ottosson H, Skerfving S, Oskarsson A (2002) Cadmium in blood and urine—impact of sex, age, dietary intake, iron status, and former smoking–association of renal effects. Environ Health Perspect 110(12):1185–1190
Dumont C, Girard M, Bellavance F, Noël F (1998) Mercury levels in the Cree population of James Bay, Quebec, from 1988 to 1993/94. CMAJ 158(11):1439–1445
Lindeman RD, Tobin J, Shock NW (1985) Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 33(4):278–285
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Skalnaya, M.G., Tinkov, A.A., Demidov, V.A. et al. Hair Toxic Element Content in Adult Men and Women in Relation to Body Mass Index. Biol Trace Elem Res 161, 13–19 (2014). https://doi.org/10.1007/s12011-014-0082-9
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DOI: https://doi.org/10.1007/s12011-014-0082-9