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Effect of Selenium on Selenoprotein Expression in the Adipose Tissue of Chickens

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Abstract

This study describes the effects of selenium (Se) deficiency on the messenger ribonucleic acid (mRNA) expression of 25 selenoproteins (Sels) (including glutathione peroxidases (GPx1–GPx4), thioredoxin reductases (TrxR1–TrxR3), iodothyronine deiodinases (ID1–ID3), selenophosphate synthetase 2 (SPS2), 15-kDa Sel (Sel15), SelH, SelI, SelK, SelM, Sepn1, SelO, Sepx, Selpb, SelS, SelT, SelW, Sepp1, and SelU in the adipose tissues (subcutaneous adipose, visceral adipose, and articular adipose) of chickens. One hundred and fifty 1-day-old chickens were randomly assigned to two groups of 75 each and were fed a low-Se diet (0.032 mg/kg Se) or a control diet (0.282 mg/kg Se). The expression levels of 25 Sel mRNAs were determined on days 35, 45, and 55 from three parts (subcutaneous adipose, visceral adipose, and articular adipose) of the chicken adipose tissues. The results showed that the expression levels of the 25 Sel mRNAs were significantly lower (P < 0.05) in the low-selenium group than in the control group. In addition, the Sel mRNA expression levels in the three adipose tissues were observed to decrease in a time-dependent manner with increasing feeding time.

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Acknowledgments

This study was supported by the Major Projects of International Cooperation and Exchanges NSFC (31320103920), the National Natural Science Foundation of China (31272626), the Doctoral Fund of the Ministry of Education of China (20122325110018), and the Heilongjiang Postdoctoral Fund (LBH-Z13028). The authors thank Elsevier English Language Editing System in correcting grammatical, spelling, and other common errors.

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Authors and Affiliations

  1. Department of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People’s Republic of China

    Yang Liang, Shi-lei Lin, Cong-wu Wang, Hai-dong Yao, Zi-wei Zhang & Shi-wen Xu

  2. College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People’s Republic of China

    Zi-wei Zhang & Shi-wen Xu

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  1. Yang Liang
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  2. Shi-lei Lin
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Correspondence to Zi-wei Zhang or Shi-wen Xu.

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Liang, Y., Lin, Sl., Wang, Cw. et al. Effect of Selenium on Selenoprotein Expression in the Adipose Tissue of Chickens. Biol Trace Elem Res 160, 41–48 (2014). https://doi.org/10.1007/s12011-014-0024-6

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  • DOI: https://doi.org/10.1007/s12011-014-0024-6

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