Skip to main content

Advertisement

SpringerLink
Log in

Effects of Selenium-Enriched Agaricus blazei Murill on Liver Metabolic Dysfunction in Mice, a Comparison with Selenium-Deficient Agaricus blazei Murill and Sodium Selenite

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

In the present study, we investigated the effects of Se-enriched Agaricus blazei Murill (Se-AbM) on liver injury in mice induced by acute alcohol administration. Mice received ethanol (5 g/kg body weight (BW)) by gavage every 12 h for a total of 3 doses. Se-AbM was administrated before ethanol administration. Subsequent serum alanine aminotransferase (ALT) level, aspartate aminotransaminase (AST) level, maleic dialdehyde (MDA) level, hepatic total antioxidant status (TAOS), nuclear factor kappa B (NF-κB) level, polymorphonuclear cells (PMN) level, interleukin-1β (IL-1β) level, inducible nitric oxide synthase (iNOS) level, tumor necrosis factor-α (TNF-α) level, intercellular adhesion molecule 1 (ICAM-1), and cyclooxygenase-2 (COX-2) were determined by ELISA and immunohistochemistry, respectively. Se-AbM administration markedly (p < 005) decreased serum ALT, AST, and MDA levels, hepatic IL-1β and TNF-α levels, as well as PMN infiltration and the expression of ICAM-1, COX-2, iNOS, and NF-κB compared with alcohol administration. In conclusion, we observed that Se-AbM supplementation could restrain the hepatic damage caused by acute alcohol exposure.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Bataller R, Brenner DA (2005) Liver fibrosis. J Clin Invest 115:209–218

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. McClain CJ, Cohen DA (1989) Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology 9:349–351

    Article  CAS  PubMed  Google Scholar 

  3. Neuman MG (2003) Cytokines in alcoholic liver. Alcohol Res Health 27:313–322

    Google Scholar 

  4. Ramadori G, Saile B (2004) Portal tract fibrogenesis in the liver. Lab Investig 84:153–159

    Article  PubMed  Google Scholar 

  5. Hoffman DJ (2002) Role of selenium toxicity and oxidative stress in aquatic birds. Aquat Toxicol 57:11–26

    Article  CAS  PubMed  Google Scholar 

  6. Hofeman DG, Sunde RA, Hocksfro WG (1974) Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat. J Nutr 104:580

    Google Scholar 

  7. Thompson KG, Fraser AJ, Harrop BM (1980) Glutathione peroxidase activity in bovine serum and electrolytes in relation to selenium concentrations of blood, serum and liver. Res Vet Sci 28:321–324

    CAS  PubMed  Google Scholar 

  8. Zhang J, Wang X, Xu T (2008) Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with se-methylselenocysteine in mice. Toxicol Sci 101:22–31

    Article  CAS  PubMed  Google Scholar 

  9. Han C, Li J, Hui Q (2008) Determination of trace elements in Jinqi, a traditional Chinese medicine. Biol Trace Elem Res 122:122–126

    Article  CAS  PubMed  Google Scholar 

  10. Wasser SP, Weis AL (1999) Therapeutic effects of substances occurring in higher basidiomycetes mushrooms: a modern perspective. Crit Rev Immunol 19:65–96

    CAS  PubMed  Google Scholar 

  11. Hsu CH, Liao YL, Lin SC et al (2007) The mushroom Agaricus brasiliensis in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blind and placebo-controlled clinical trial. J Altern Complement Med 13:97–102

    Article  PubMed  Google Scholar 

  12. Chen L, Shao HJ, Su YB (2004) Coimmunization of Agaricus brasiliensis extract with hepatitis B virus core protein through DNA vaccine enhances cellular and humoral immune responses. Int Immunopharmacol 4:403–409

    Article  CAS  PubMed  Google Scholar 

  13. Carson E, Pruett S (1996) Development and characterization of a binge drinking model in mice for evaluation of the immunological effects of ethanol. Alcohol Clin Exp Res 20:132–138

    Article  CAS  PubMed  Google Scholar 

  14. Laight DW, Gunnarsson PT, Kaw AV, Carrier MJ (1999) Physiological microassay of plasma total antioxidant status in a model of endothelial dysfunction in the rat following experimental oxidant stress in vivo. Environ Toxicol Pharmacol 7:27–31

    Article  CAS  PubMed  Google Scholar 

  15. Baldi E, Burra P, Plebani M, Salvagnini M (1993) Serum malondialdehyde and mitochondrial aspartate aminotransferase activity as markers of chronic alcohol intake and alcoholic liver disease. Ital J Gastroenterol 25:429–432

    CAS  PubMed  Google Scholar 

  16. Agarwal M, Srivastava VK, Saxena KK, Kumar A (2006) Hepatoprotective activity of beta vulgaris against CCl4-induced hepatic injury in rats. Fitoterapia 77:91–93

    Article  CAS  PubMed  Google Scholar 

  17. Pratt DS, Kaplan MM (2000) Evaluation of abnormal liver-enzyme results in asymptomatic patients. N Engl J Med 342:1266–1271

    Article  CAS  PubMed  Google Scholar 

  18. Vaca CE, Wilhelm J, Harms-Ringdahl M (1988) Interaction of lipid peroxidation products with DNA. A review. Mutat Res 195:137–149

    Article  CAS  PubMed  Google Scholar 

  19. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–358

    Article  CAS  PubMed  Google Scholar 

  20. Thurman RG, Bradford BU, Iimuro Y et al (1999) Mechanisms of alcohol-induced hepatotoxicity: studies in rats. Front Biosci 4:42–46

    Article  Google Scholar 

  21. McClain CJ, Shedlofsky S, Barve S, Hill DB (1997) Cytokines and alcoholic liver disease. Alcohol Health Res World 21:317–320

    CAS  PubMed  Google Scholar 

  22. Sass G, Koerber K, Bang R, Guehring H, Tiegs G (2001) Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice. J Clin Invest 107:439–447

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  23. Ito Y, Abril Edward R, Bethea Nancy W, McCuskey Robert S (2004) Role of nitric oxide in hepatic microvascular injury elicited by acetaminophen in mice. Am J Physiol Gastrointest Liver Physiol 286:60–67

    Article  Google Scholar 

  24. Sass G, Heinlein S, Agli A, Bang R, Schümann J, Tiegs G (2002) Cytokine expression in three mouse models of experimental hepatitis. Cytokine 19:115–120

    Article  CAS  PubMed  Google Scholar 

  25. Jaruga B, Hong F, Kim WH, Gao B (2004) IFN-gamma/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1. Am J Physiol Gastrointest Liver Physiol 287:1044–1052

    Article  Google Scholar 

  26. Fujikura S, Mizuhara H, Miyazawa Y, Fujiwara H, Kaneda K (1999) Kinetics and localization of lymphoblasts that proliferate in the mutine liver after Concanavalin A administration. Biomed Res 17:129–139

    Google Scholar 

  27. Mandai M, Yoshimura N, Yoshida M, Iwaki M, Honda Y (1994) The role of nitric oxide synthase in endotoxin-induced uveitis: effects of NG-nitro-l-arginine. Invest Ophthalmol Vis Sci 35:3673–3680

    CAS  PubMed  Google Scholar 

  28. Endres S, Fülle HJ, Sinha B, Stoll D, Dinarello CA, Gerzer R, Weber PC (1991) Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-alpha and interleukin-1 beta by human mononuclear cells. Immunology 72:56–60

    CAS  PubMed Central  PubMed  Google Scholar 

  29. Guo JY, Li CY, Ruan YP, Sun M, Qi XL, Zhao BS, Luo F (2009) Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain. Eur J Pharmacol 612:54–60

    Article  CAS  PubMed  Google Scholar 

  30. Zingarelli B, Sheehan M, Wong HR (2003) Nuclear factor-kappaB as a therapeutic target in critical care medicine. Crit Care Med 31:S105–S111

    Article  CAS  PubMed  Google Scholar 

  31. Wertheimer SJ, Myers CL, Wallace RW et al (1992) Intercellular adhesion molecule-1 gene expression in human endothelial cells. Differential regulation by tumor necrosis factor-alpha and phorbol myristate acetate. J Biol Chem 267:12030–12035

    CAS  PubMed  Google Scholar 

  32. Matsutani T, Kang SC, Miyashita M et al (2007) Liver cytokine production and ICAM-1 expression following bone fracture, tissue trauma, and hemorrhage in middle-aged mice. Am J Physiol Gastrointest Liver Physiol 292:G268–G274

    Article  CAS  PubMed  Google Scholar 

  33. Kono H, Arteel GE, Rusyn I, Sies H, Thurman RG (2001) Ebselen prevents early alcohol-induced liver injury in rats. Free Radic Biol Med 30:403–411

    Article  CAS  PubMed  Google Scholar 

  34. Mandrekar P, Bala S, Catalano D, Kodys K, Szabo G (2009) The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. J Immunol 183:1320–1327

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

Supported by the Foundation of Department of Education of Heilongjiang Province (No.12521294).

Author information

Authors and Affiliations

  1. Department of Infectious Disease, The Fourth Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, People’s Republic of China

    Lei Yu & Li-Ying Zhu

  2. Department of Pathology, Zhengzhou Railway Vocational and Technical College, Zhengzhou, 450000, Henan, People’s Republic of China

    Shaolong Yang

  3. Department of Ophthalmology, The Fourth Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, People’s Republic of China

    Lei Sun

  4. Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis; Department of Central Laboratory, the Second Part of First Hospital, Jilin University, 130032, Changchun, People’s Republic of China

    Yan-Fang Jiang

Authors
  1. Lei Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shaolong Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lei Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yan-Fang Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Li-Ying Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Yan-Fang Jiang or Li-Ying Zhu.

Additional information

Lei Yu, Shaolong Yang and Lei Sun are co-first authors

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yu, L., Yang, S., Sun, L. et al. Effects of Selenium-Enriched Agaricus blazei Murill on Liver Metabolic Dysfunction in Mice, a Comparison with Selenium-Deficient Agaricus blazei Murill and Sodium Selenite. Biol Trace Elem Res 160, 79–84 (2014). https://doi.org/10.1007/s12011-014-0022-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12011-014-0022-8

Keywords

Search

Navigation