Biological Trace Element Research

, Volume 157, Issue 2, pp 130–137 | Cite as

A Comparative Study on the Effects of Excess Iodine and Herbs with Excess Iodine on Thyroid Oxidative Stress in Iodine-Deficient Rats

  • Tianshu GaoEmail author
  • Rui Shi
  • Tengche Qi
  • Huisi Yin
  • Lan Mei
  • Xiaoqing Han
  • Peng Cui


This study aimed to compare the effect of excess iodine and herbs with excess iodine on treating iodine deficiency-induced goiter from the perspective of oxidative stress and to measure selenium values in Chinese herbs. One hundred twenty 4-week-old Wistar rats were selected and randomly divided into four groups after inducing iodine-deficiency goiter: normal control group (NC), model control group (MC), iodine excess group (IE), and herbs with iodine excess group (HIE). The activities of oxidative enzymes and levels of oxidative products were measured using biochemical tests. The expression of 4-hydroxynonenal (4-HNE) in the thyroid was detected by immunohistochemistry and the expression of peroxiredoxin 5 (PRDX5) by the Western blot and immunohistochemistry. Selenium values in iodine-excessive herbs were measured by hydride generation-atomic fluorescence spectrometry. The herbs with iodine excess were tested to contain rich selenium. The activities of superoxide dismutase (SOD) and PRDX5 increased markedly, and the values of malondialdehyde (MDA) and 4-HNE decreased significantly in the HIE group. In conclusion, compared with excess iodine, herbs with excess iodine damaged thyroid follicular cells less, which may be related to the increase of antioxidant capacity and rich selenium values in iodine-excessive herbs.


Oxidative stress Goiter Iodine Herbs with excess iodine 



This work received grants from the Specialized Research Fund for the Doctoral Program of Higher Education of China (grant no. 20092133110004), Liaoning Province Education Department (grant no. 2009A492), and Talents Project of Liaoning Province Education Department (grant no. LR201026). And thanks for the support from Prof. Teng Weiping and Prof. Shan Zhongyan, Endocrinology and Metabolism Institute, China Medical University.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Tianshu Gao
    • 1
    Email author
  • Rui Shi
    • 1
  • Tengche Qi
    • 1
  • Huisi Yin
    • 1
  • Lan Mei
    • 1
  • Xiaoqing Han
    • 1
  • Peng Cui
    • 1
  1. 1.Chronic Disease Dept. of Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyangChina

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