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Overweight and Obesity Associated With Increased Total Serum Calcium Level: Comparison of Cross-sectional Data in the Health Screening for Teaching Faculty

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Abstract

Obesity is a risk of cardiovascular diseases. Our previous studies revealed that serum calcium level may have influence in the blood pressure to older male subjects. The aim of this study was to evaluate the relationship between total serum calcium level and overweight and obesity subjects. In our study, overweight and obesity status and total serum calcium level were measured among 2,503 subjects, at age range of 22–94 years, who were recruited for the routine health screening in 2006. The estimated mean for age (p < 0.001), white blood cell count (p = 0.037), hemoglobin concentration (p < 0.001), red blood cell count (p < 0.001), total serum calcium level (p < 0.001), total cholesterol weight (p < 0.001), HDL-cholesterol (p < 0.001), LDL-cholesterol (p < 0.001), and triglyceride (p < 0.001) of overweight and obesity subjects were significantly higher than those of non-overweight subjects. The prevalence of overweight/obesity in subjects according to the log-transformed total serum calcium level quartiles was 16.3–30.5 %. The prevalence of overweight/obesity subjects showed trends that were significant according to the total serum calcium level quartiles (p < 0.001). The odds ratios (ORs) and 95 % confidence intervals (CIs) for overweight/obesity of the second, third, and fourth quartiles compared to the lowest quartile were 1.407 (1.050–1.883), 1.543 (1.136–2.095), and 1.360 (0.995–1.859), respectively, after adjusting for sex and age (p < 0.001). These findings suggest that a higher prevalence of adult overweight/obesity is weakly associated with higher total serum calcium level in the Chinese population.

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References

  1. Li X, Xu J, Yao H, Guo Y, Chen M, Lu W (2012) Obesity and overweight prevalence and its association with undiagnosed hypertension in Shanghai population, China: a cross-sectional population-based survey. Front Med 6(3):322–328. doi:10.1007/s11684-012-0204-8

    Article  PubMed  Google Scholar 

  2. Du T, Sun X, Yin P, Huo R, Ni C, Yu X (2013) Increasing trends in central obesity among Chinese adults with normal body mass index, 1993–2009. BMC Public Health 13:327. doi:10.1186/1471-2458-13-3271471-2458-13-327

    Article  PubMed  Google Scholar 

  3. Garg SK, Maurer H, Reed K, Selagamsetty R (2013) Diabetes and cancer: two diseases with obesity as a common risk factor. Diabetes Obes Metab. doi:10.1111/dom.12124

    Google Scholar 

  4. Brown EM, MacLeod RJ (2001) Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 81(1):239–297

    PubMed  CAS  Google Scholar 

  5. Molostvov G, Fletcher S, Bland R, Zehnder D (2008) Extracellular calcium-sensing receptor mediated signalling is involved in human vascular smooth muscle cell proliferation and apoptosis. Cell Physiol Biochem 22(5–6):413–422. doi:10.1159/000185484000185484

    Article  PubMed  CAS  Google Scholar 

  6. Hofer AM, Brown EM (2003) Extracellular calcium sensing and signalling. Nat Rev Mol Cell Biol 4(7):530–538. doi:10.1038/nrm1154nrm1154

    Article  PubMed  CAS  Google Scholar 

  7. Pietrobon D, Di Virgilio F, Pozzan T (1990) Structural and functional aspects of calcium homeostasis in eukaryotic cells. Eur J Biochem 193(3):599–622

    Article  PubMed  CAS  Google Scholar 

  8. Yao Y, He L, Jin Y, Chen Y, Tang H, Song X, Ding L, Qi Q, Huang Z, Wang Q, Yu J (2013) The relationship between serum calcium level, blood lipids, and blood pressure in hypertensive and normotensive subjects who come from a normal university in east of China. Biol Trace Elem Res 153(1–3):35–40. doi:10.1007/s12011-013-9646-3

    Article  PubMed  CAS  Google Scholar 

  9. Jin Y, He L, Wang Q, Chen Y, Ren X, Tang H, Song X, Ding L, Qi Q, Huang Z, Yu J, Yao Y (2013) Serum calcium levels are not associated with coronary heart disease. Vasc Health Risk Manag 9:517–520. doi:10.2147/VHRM.S49136vhrm-9-517

    PubMed  Google Scholar 

  10. Berridge MJ, Bootman MD, Roderick HL (2003) Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 4(7):517–529. doi:10.1038/nrm1155

    Article  PubMed  CAS  Google Scholar 

  11. Sonnleitner A, Conti A, Bertocchini F, Schindler H, Sorrentino V (1998) Functional properties of the ryanodine receptor type 3 (RyR3) Ca2+ release channel. EMBO J 17(10):2790–2798. doi:10.1093/emboj/17.10.2790

    Article  PubMed  CAS  Google Scholar 

  12. Park SH, Kim SK, Bae YJ (2012) Relationship between serum calcium and magnesium concentrations and metabolic syndrome diagnostic components in middle-aged Korean men. Biol Trace Elem Res 146(1):35–41. doi:10.1007/s12011-011-9224-5

    Article  PubMed  CAS  Google Scholar 

  13. Saltevo J, Niskanen L, Kautiainen H, Teittinen J, Oksa H, Korpi-Hyovalti E, Sundvall J, Mannisto S, Peltonen M, Mantyselka P, Vanhala M (2011) Serum calcium level is associated with metabolic syndrome in the general population: FIN-D2D study. Eur J Endocrinol 165(3):429–434. doi:10.1530/EJE-11-0066EJE-11-0066

    Article  PubMed  CAS  Google Scholar 

  14. Lind L, Jakobsson S, Lithell H, Wengle B, Ljunghall S (1988) Relation of serum calcium concentration to metabolic risk factors for cardiovascular disease. BMJ 297(6654):960–963

    Article  PubMed  CAS  Google Scholar 

  15. Cho GJ, Shin JH, Yi KW, Park HT, Kim T, Hur JY, Kim SH (2011) Serum calcium level is associated with metabolic syndrome in elderly women. Maturitas 68(4):382–386. doi:10.1016/j.maturitas.2011.01.013S0378-5122(11)00029-6

    Article  PubMed  CAS  Google Scholar 

  16. van Klaveren RJ, Hoet PH, Pype JL, Demedts M, Nemery B (1997) Increase in gamma-glutamyltransferase by glutathione depletion in rat type II pneumocytes. Free Radic Biol Med 22(3):525–534

    Article  PubMed  Google Scholar 

  17. Johns KA (1986) The programming environment for statistical tabulation. Int J Biomed Comput 19(3–4):161–173

    Article  PubMed  CAS  Google Scholar 

  18. Yang J, Wang P, Liu C, He X, Zhang Y, Tao X, Zhao Y, Wang L (2013) [Relationship of ionized calcium and 25-(OH) D in serum with obesity]. Wei Sheng Yan Jiu 42(1):78–81, 86

    PubMed  Google Scholar 

  19. Thomas AP, Dunn TN, Drayton JB, Oort PJ, Adams SH (2013) A dairy-based high calcium diet improves glucose homeostasis and reduces steatosis in the context of preexisting obesity. Obesity (Silver Spring) 21(3):E229–E235. doi:10.1002/oby.20039

    Article  CAS  Google Scholar 

  20. Aguirre Castaneda R, Nader N, Weaver A, Singh R, Kumar S (2012) Response to vitamin D3 supplementation in obese and non-obese Caucasian adolescents. Horm Res Paediatr 78(4):226–231. doi:10.1159/000343446000343446

    Article  PubMed  CAS  Google Scholar 

  21. Shapses SA, Lee EJ, Sukumar D, Durazo-Arvizu R, Schneider SH (2013) The effect of obesity on the relationship between serum parathyroid hormone and 25-hydroxyvitamin D in women. J Clin Endocrinol Metab 98(5):E886–E890. doi:10.1210/jc.2012-3369jc.2012-3369

    Article  PubMed  Google Scholar 

  22. Invitti C (2002) Obesity and low-grade systemic inflammation. Minerva Endocrinol 27(3):209–214

    PubMed  CAS  Google Scholar 

  23. O'Neill CM, Lu C, Corbin KL, Sharma PR, Dula SB, Carter JD, Ramadan JW, Xin W, Lee JK, Nunemaker CS (2013) Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice. Endocrinology 154(9):3077–3088. doi:10.1210/en.2012-2138en.2012-2138

    Article  PubMed  Google Scholar 

  24. Vaidya A, Underwood PC, Annes JP, Sun B, Williams GH, Forman JP, Williams JS (2013) The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes. Metabolism 62(4):539–547. doi:10.1016/j.metabol.2012.10.001S0026-0495(12)00383-6

    Article  PubMed  CAS  Google Scholar 

  25. Laraichi S, Parra P, Zamanillo R, El Amarti A, Palou A, Serra F (2013) Dietary supplementation of calcium may counteract obesity in mice mediated by changes in plasma fatty acids. Lipids 48(8):817–826. doi:10.1007/s11745-013-3798-y

    Article  PubMed  CAS  Google Scholar 

  26. He Y, Perry B, Bi M, Sun H, Zhao T, Li Y, Sun C (2013) Allosteric regulation of the calcium-sensing receptor in obese individuals. Int J Mol Med. doi:10.3892/ijmm.2013.1408

    Google Scholar 

  27. Sun C, Wang L, Yan J, Liu S (2012) Calcium ameliorates obesity induced by high-fat diet and its potential correlation with p38 MAPK pathway. Mol Biol Rep 39(2):1755–1763. doi:10.1007/s11033-011-0916-x

    Article  PubMed  CAS  Google Scholar 

  28. Song Q, Sergeev IN (2012) Calcium and vitamin D in obesity. Nutr Res Rev 25(1):130–141. doi:10.1017/S0954422412000029

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This research was supported by the National Natural Science Foundation of China (81072367), the Anhui Provincial Natural Science Foundation (090413126 and 1308085MH135), and the Wannan Medical key scientific research projects engagement fund (WK2013Z01).

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Authors and Affiliations

  1. School of Public Health, Wannan Medical University, Wuhu, 241002, Anhui, People’s Republic of China

    Xiao-hua Ren, Ying-shui Yao, Lian-ping He, Yue-long Jin, Wei-wei Chang, Jie Li, Yan Chen, Xiu-li Song, Hui Tang, Ling-ling Ding & Dao-xia Guo

  2. Laboratory of Environment and health, School of Earth and Environment, Anhui University of Science and Technology, Huainan, 232991, Anhui, People’s Republic of China

    Ying-shui Yao & Chao-ping Li

  3. Department of Medical Parasitology, Wannan Medical University College, No. 22 Road Wenchangxi, Yijiang District, Wuhu, Anhui, 241002, People’s Republic of China

    Chao-ping Li

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  1. Xiao-hua Ren
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  2. Ying-shui Yao
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  3. Lian-ping He
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  7. Yan Chen
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Correspondence to Chao-ping Li.

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Xiao-hua Ren and Ying-shui Yao contributed equally to this work.

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Ren, Xh., Yao, Ys., He, Lp. et al. Overweight and Obesity Associated With Increased Total Serum Calcium Level: Comparison of Cross-sectional Data in the Health Screening for Teaching Faculty. Biol Trace Elem Res 156, 74–78 (2013). https://doi.org/10.1007/s12011-013-9856-8

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  • DOI: https://doi.org/10.1007/s12011-013-9856-8

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