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Selenium, Zinc, and Copper Plasma Levels in Patients with Schizophrenia: Relationship with Metabolic Risk Factors

Biological Trace Element Research volume 156, pages 22–28 (2013)Cite this article

Abstract

The aim of this study was to determine the plasma selenium (Se), copper (Cu), and zinc (Zn) levels and to evaluate their possible association with metabolic syndrome (MetS) components in patients with schizophrenia. The study group consisted of 60 patients with schizophrenia and 60 sex- and age-matched healthy controls. Anthropometric measurements, blood pressure, and biochemical analysis of fasting blood were performed in all subjects. Patients with schizophrenia had significantly higher plasma Cu concentrations compared with controls (0.97 ± 0.31 vs. 0.77 ± 0.32 mg/L, p = 0.001). The plasma Cu concentration showed a positive correlation with plasma glucose and diastolic blood pressure in the patient groups (r s  = 0.263, p < 0.05 and r s  = 0.272, p < 0.05, respectively). The plasma Se level correlated positive with MetS score (r s  = 0.385, p < 0.01), waist circumference (r s  = 0.344, p < 0.05), plasma glucose (r s  = 0.319, p < 0.05), and triglyceride concentrations (r s  = 0.462, p < 0.001) in patients with schizophrenia. Plasma Zn did not correlate with any of the MetS components. These results suggest that alterations in plasma Cu and Se levels in medicated patients with schizophrenia could be associated with metabolic risk factors.

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References

  1. Laursen TM, Munk-Olsen T, Vestergaard M (2012) Life expectancy and cardiovascular mortality in persons with schizophrenia. Curr Opin Psychiatry 25:83–88

    PubMed  Article  Google Scholar 

  2. Casey DA, Rodriguez M, Northcott C, Vickar G, Shihabuddin L (2011) Schizophrenia: medical illness, mortality, and aging. Int J Psychiatry Med 41:245–251

    PubMed  Article  Google Scholar 

  3. Hert MD, Dekker JM, Wood D, Kahl KG, Möller HJ (2009) Cardiovascular disease and diabetes in people with severe mental illness. Rev Psiquiatr Salud Ment 2:49–59

    PubMed  Article  Google Scholar 

  4. Papanastasiou E (2013) The prevalence and mechanisms of metabolic syndrome in schizophrenia: a review. Ther Adv Psychopharmacol 3:33–51

    PubMed  Article  Google Scholar 

  5. Ceriello A, Motz E (2004) Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol 24:816–823

    PubMed  Article  CAS  Google Scholar 

  6. Roberts CK, Sindhu KK (2009) Oxidative stress and metabolic syndrome. Life Sci 84:705–712

    PubMed  Article  CAS  Google Scholar 

  7. Kudrin AV (2000) Trace elements in regulation of NF-kB activity. J Trace Elem Med Biol 14:129–142

    PubMed  Article  CAS  Google Scholar 

  8. Ford ES, Mokdad AH, Giles WH, Brown DW (2003) The metabolic syndrome and antioxidant concentrations: findings from the Third National Health and Nutrition Examination Survey. Diabetes 52:2346–2352

    PubMed  Article  CAS  Google Scholar 

  9. Arnaud J, de Lorgeril M, Akbaraly T, Salen P, Arnout J, Cappuccio FP, van Dongen MC, Donati MB, Krogh V, Siani A, Iacoviello L, European Collaborative Group of the IMMIDIET Project (2012) Gender differences in copper, zinc and selenium status in diabetic-free metabolic syndrome European population—the IMMIDIET study. Nutr Metab Cardiovasc Dis 22:517–524

    PubMed  Article  CAS  Google Scholar 

  10. Pizent A, Pavlovic M, Jurasovic J, Dodig S, Pasalic D, Mujagic R (2010) Antioxidants, trace elements and metabolic syndrome in elderly subjects. J Nutr Health Aging 14:866–871

    PubMed  Article  CAS  Google Scholar 

  11. Obeid O, Elfakhani M, Hlais S, Iskandar M, Batal M, Mouneimne Y, Adra N, Hwalla N (2008) Plasma copper, zinc, and selenium levels and correlates with metabolic syndrome components of Lebanese adults. Biol Trace Elem Res 123:58–65

    PubMed  Article  CAS  Google Scholar 

  12. Alberti KG, Zimmet P, Shaw J, IDF Epidemiology Task Force Consensus Group (2005) The metabolic syndrome—a new worldwide definition. Lancet 366:1059–1062

    PubMed  Article  Google Scholar 

  13. Bland JM, Altman DG (1996) Statistics notes: transformations, means, and confidence intervals. BMJ 312:1079

    PubMed  Article  CAS  Google Scholar 

  14. Gardner DM, Murphy AL, O’Donnell H, Centorrino F, Baldessarini RJ (2010) International consensus study of antipsychotic dosing. Am J Psychiatry 167:686–693

    PubMed  Article  Google Scholar 

  15. Lindenmayer JP, Czobor P, Volavka J, Citrome L, Sheitman B, McEvoy JP, Cooper TB, Chakos M, Lieberman JA (2003) Changes in glucose and cholesterol levels in patients with schizophrenia treated with typical or atypical antipsychotics. Am J Psychiatry 160:290–296

    PubMed  Article  Google Scholar 

  16. Newcomer W (2005) Metabolic risk during antipsychotic treatment. Clin Ther 26:1936–1946

    Article  Google Scholar 

  17. Mitchell AJ, Vancampfort D, Sweers K, van Winkel R, Yu W, De Hert M (2013) Prevalence of metabolic syndrome and metabolic abnormalities in schizophrenia and related disorders—a systematic review and meta-analysis. Schizophr Bull 39:306–318

    PubMed  Article  Google Scholar 

  18. Pfeiffer CC, Iliev V (1972) A study of zinc deficiency and copper excess in the schizophrenias. Int Rev Neurobiol 1:141–165

    CAS  Google Scholar 

  19. Yanik M, Kocyigit A, Tutkun H, Vural H, Herken H (2004) Plasma manganese, selenium, zinc, copper, and iron concentrations in patients with schizophrenia. Biol Trace Elem Res 98:109–117

    PubMed  Article  CAS  Google Scholar 

  20. Herrán A, García-Unzueta MT, Fernández-González MD, Vázquez-Barquero JL, Alvarez C, Amado JA (2000) Higher levels of serum copper in schizophrenic patients treated with depot neuroleptics. Psychiatr Res 94:51–58

    Article  Google Scholar 

  21. Nechifor M, Vaideanu C, Palamaru I, Borza C, Mindreci I (2004) The influence of some antipsychotics on erythrocyte magnesium and plasma magnesium, calcium, copper and zinc in patients with paranoid schizophrenia. J Am Coll Nutr 23:549S–551S

    PubMed  Article  CAS  Google Scholar 

  22. Crammer JL (1983) Trace elements in neuropsychiatry. Br J Psychiatry 143:85–88

    PubMed  Article  CAS  Google Scholar 

  23. Bowman MB, Lewis MS (1982) The copper hypothesis of schizophrenia: a review. Neurosci Biobehav 6:321–328

    Article  CAS  Google Scholar 

  24. Bo S, Durazzo M, Gambino R, Berutti C, Milanesio N, Caropreso A, Gentile L, Cassader M, Cavallo-Perin P, Pagano G (2008) Associations of dietary and serum copper with inflammation, oxidative stress, and metabolic variables in adults. J Nutr 138:305–310

    PubMed  CAS  Google Scholar 

  25. Aguilar MV, Saavedra P, Arrieta FJ, Mateos CJ, González MJ, Meseguer I, Martínez-Para MC (2007) Plasma mineral content in type-2 diabetic patients and their association with the metabolic syndrome. Ann Nutr Metab 51(5):402–406

    PubMed  Article  CAS  Google Scholar 

  26. Bitanihirwe BK, Cunningham MG (2009) Zinc: the brain’s dark horse. Synapse 63:1029

    PubMed  Article  CAS  Google Scholar 

  27. Ogundahunsi OA, Duduyemi OO, Soyinka OO (2011) Effects of antipsychotic drugs on the levels of selected trace elements in schizophrenia. Afr Sci 12:77–82

    Google Scholar 

  28. Arinola OG, Idonije OB (2009) Status of plasma nitric oxide and non-enzymatic antioxidants before and after antipsychotic treatment in Nigerian patients with schizophrenia. J Res Med Sci 14:37–42

    PubMed  CAS  Google Scholar 

  29. Craven C, Duggan PF, Buckley N, Gaughran F (1997) Serum zinc levels in patients with schizophrenia and their mothers. Schizophr Res 26:83–84

    PubMed  Article  CAS  Google Scholar 

  30. Rayman MP (2012) Selenium and human health. Lancet 379:1256–1268

    PubMed  Article  CAS  Google Scholar 

  31. Rayman MP, Stranges S (2013) Epidemiology of selenium and type 2 diabetes: can we make sense it? Free Radic Biol Med. doi:10.1016/j.freeradbiomed.2013.04.003

    Google Scholar 

  32. Maksimović ZJ, Djujić I, Jović V, Rsumović M (1992) Selenium deficiency in Yugoslavia. Biol Trace Elem Res 33:187–196

    PubMed  Article  Google Scholar 

  33. Mihajlovic MB, Vasiljevic Z, Sobajic S, Jovanovic IB, Pesut O, Matic G (2003) Antioxidant status of patients with acute myocardial infarction. Trace Elem Electrolyte 20:5–7

    Google Scholar 

  34. Pesut O, Backovic D, Sobajic S (2005) Dietary selenium supplementation of pigs and broilers as a way of producing selenium enriched meat. Acta Vet (Beograd) 55:483–492

    Article  Google Scholar 

  35. Pavlović Z, Miletic I, Jokic Z, Stevanovic J, Sobajic S, Bulat Z (2013) The influence of selenium supplementation of animal feed on human selenium intake in Serbia. Biotech Anim Husb 29:345–352

    Article  Google Scholar 

  36. Duffield AJ, Thomson CD, Hill KE, Williams S (1999) An estimation of selenium requirements for New Zealanders. Am J Clin Nutr 70:896–903

    PubMed  CAS  Google Scholar 

  37. Vaddadi KS, Soosai E, Vaddadi G (2003) Low blood selenium concentrations in schizophrenic patients on clozapine. Br J Clin Pharmacol 55:307–309

    PubMed  Article  CAS  Google Scholar 

  38. Alertsen AR, Aukrust A, Skaug OE (1986) Selenium concentration in blood and serum from patients with mental diseases. Acta Psychiatr Scand 74:217–219

    PubMed  Article  CAS  Google Scholar 

  39. Yang KC, Lee LT, Lee YS, Huang HY, Chen CY, Huang KC (2010) Serum selenium concentration is associated with metabolic factors in the elderly: a cross-sectional study. Nutr Metab (Lond) 7:38

    Article  Google Scholar 

  40. Stranges S, Laclaustra M, Ji C, Cappuccio FP, Navas-Acien A, Ordovas JM, Rayman M, Guallar E (2010) Higher selenium status is associated with adverse blood lipid profile in British adults. J Nutr 140:81–87

    PubMed  Article  CAS  Google Scholar 

  41. Ghayour-Mobarhan M, Taylor A, Lanham-New S, Lamb DJ, Nezhad MA, Kazemi-Bajestani SMR, Ghafouri F, Livingstone C, Wang T, Ferns GAA (2008) Serum selenium and glutathione peroxidase in patients with obesity and metabolic syndrome. Pak J Nutr 7:112–117

    Article  CAS  Google Scholar 

  42. Burk RF, Hill KE (1993) Regulation of selenoproteins. Annu Rev Nutr 13:65–81

    PubMed  Article  CAS  Google Scholar 

  43. Fairweather-Tait SJ, Bao Y, Broadley MR, Collings R, Ford D, Hesketh JE, Hurst R (2011) Selenium in human health and disease. Antioxid Redox Signal 14:1337–1383

    PubMed  Article  CAS  Google Scholar 

  44. Yang SJ, Hwang SY, Choi HY, Yoo HJ, Seo JA, Kim SG, Kim NH, Baik SH, Choi DS, Choi KM (2011) Serum selenoprotein P levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis. J Clin Endocrinol Metabol 96:E1325–E1329

    Article  CAS  Google Scholar 

  45. Steinbrenner H, Speckmann B, Pinto A, Sies H (2011) High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism. J Clin Biochem Nutr 48:40–45

    PubMed  Article  CAS  Google Scholar 

  46. Yubero-Serrano EM, Delgado-Lista J, Peña-Orihuela P et al (2013) Oxidative stress is associated with the number of components of metabolic syndrome: LIPGENE study. Exp Mol Med 45:e28. doi:10.1038/emm.2013.53

    PubMed  Article  Google Scholar 

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Acknowledgments

We appreciate the financial support from the Ministry of Education, Science and Technological Development, Republic of Serbia (project number III46001). The authors would like to thank Dr. Steve Quarrie for his help in editing the manuscript.

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Affiliations

  1. Faculty of Pharmacy, Department of Bromatology, University of Belgrade, Vojvode Stepe 450, 11221, Belgrade, Serbia

    Bojana Vidović & Brižita Đorđević

  2. Faculty of Medicine, University of Belgrade, Dr Subotića 8, 11000, Belgrade, Serbia

    Srđan Milovanović

  3. Clinic for Psychiatry, Clinical Centar of Serbia, Pasterova 2, 11000, Belgrade, Serbia

    Srđan Milovanović

  4. Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000, Belgrade, Serbia

    Sandra Škrivanj

  5. Institute for Public Health Požarevac, Jovana Šerbanovića 14, 12000, Požarevac, Serbia

    Zoran Pavlović

  6. Faculty of Pharmacy, Department of Medical Biochemistry, University of Belgrade, Vojvode Stepe 450, 11221, Belgrade, Serbia

    Aleksandra Stefanović & Jelena Kotur-Stevuljević

Authors
  1. Bojana Vidović
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  2. Brižita Đorđević
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  3. Srđan Milovanović
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  6. Aleksandra Stefanović
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  7. Jelena Kotur-Stevuljević
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Correspondence to Bojana Vidović.

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Vidović, B., Đorđević, B., Milovanović, S. et al. Selenium, Zinc, and Copper Plasma Levels in Patients with Schizophrenia: Relationship with Metabolic Risk Factors. Biol Trace Elem Res 156, 22–28 (2013). https://doi.org/10.1007/s12011-013-9842-1

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  • DOI: https://doi.org/10.1007/s12011-013-9842-1

Keywords

  • Selenium
  • Copper
  • Zinc
  • Metabolic syndrome
  • Schizophrenia