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NAA-SLR and ICP-AES Application in the Assessment of Mass Fraction of 19 Chemical Elements in Pediatric and Young Adult Prostate Glands

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Abstract

The effect of age on the mass fraction of 19 chemical elements in the intact prostate of 50 apparently healthy 0–30-year-old males was investigated by neutron activation analysis with high-resolution spectrometry of short-lived radionuclides and inductively coupled plasma atomic emission spectrometry. Mean values (M ± standard error of the mean) for mass fraction (in milligrams per kilogram, on dry weight basis) of chemical elements were as follows: Al, 77 ± 17; B, 1.31 ± 0.29; Ba, 4.0 ± 1.2; Br, 37.7 ± 4.3; Ca, 1,536 ± 189; Cl, 13,414 ± 949; Cu, 12.3 ± 2.1; Fe, 132 ± 11; K, 11,547 ± 468; Li, 0.064 ± 0.009; Mg, 922 ± 89; Mn, 1.88 ± 0.16; Na, 9,834 ± 411; P, 6,741 ± 335; S, 8,034 ± 251; Si, 199 ± 34; Sr, 1.40 ± 0.19; and Zn, 277 ± 33. The upper limit of mean mass fraction of V was ≤0.24. This work revealed that there is significant tendency for the mass fractions of Ca, K, Mg, and Zn in the prostate tissue of healthy individuals to increase with age from the time of birth up to 30 years. It means that Ca, K, Mg, and Zn mass fractions in prostate tissue are the androgen-dependent parameters. Our finding of a positive correlation between the prostatic Zn and Ca, K, Mg, P, and S mass fractions indicates that there is a special relationship of Zn with some main electrolytes (Ca, K, and Mg) and with P- and S-containing compounds in the prostate. It was shown also that high levels of Al, B, Ba, Br, Cl, Li, Na, and Sr mass fraction in prostate tissue do not indicate a direct involvement of these elements in the reproductive function of the prostate.

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References

  1. Zaichick S, Zaichick V, Nosenko S, Moskvina I (2012) Mass fractions of 52 trace elements and zinc trace element content ratios in intact human prostates investigated by inductively coupled plasma mass spectrometry. Biol Trace Elem Res 149:171–183

    Article  PubMed  CAS  Google Scholar 

  2. Hienzsch E, Schneider H-J, Anke M (1970) Vergleichende Untersuchungen zum Mengen- und Spurenelementgehalt der normalen Prostata, des Prostataadenoms und des Prostatakarzinoms. Z Urol Nephrol 63:543–546

    PubMed  CAS  Google Scholar 

  3. Leissner KM, Fielkegard B, Tisell L-E (1980) Concentration and content of zinc in human prostate. Invest Urol 18:32–35

    PubMed  CAS  Google Scholar 

  4. Zaichick V (2004) INAA and EDXRF applications in the age dynamics assessment of Zn content and distribution in the normal human prostate. J Radioanal Nucl Chem 262:229–234

    Article  CAS  Google Scholar 

  5. Zaichick S, Zaichick V (2013) Relations of morphometric parameters to zinc content in paediatric and nonhyperplastic young adult prostate glands. Andrology 1:139–146

    Article  PubMed  CAS  Google Scholar 

  6. Zaichick S, Zaichick V (2011) INAA application in the age dynamics assessment of Br, Ca, Cl, K, Mg, Mn, and Na content in the normal human prostate. J Radioanal Nucl Chem 288:197–202

    Article  CAS  Google Scholar 

  7. Zaichick S, Zaichick V (2011) The effect of age on Ag, Co, Cr, Fe, Hg, Sb, Sc, Se, and Zn contents in intact human prostate investigated by neutron activation analysis. Appl Radiat Isot 69:827–833

    Article  PubMed  CAS  Google Scholar 

  8. Zaichick V, Nosenko S, Moskvina I (2012) The effect of age on 12 chemical element contents in intact prostate of adult men investigated by inductively coupled plasma atomic emission spectrometry. Biol Trace Elem Res 147:49–58

    Article  PubMed  CAS  Google Scholar 

  9. Tisell L-E, Fjelkegard B, Leissner KH (1982) Zinc concentration and content of the dorsal, lateral and medial prostatic lobes and of periurethral adenomas in man. J Urol 128:403–405

    PubMed  CAS  Google Scholar 

  10. Feustel A, Wennrich R (1984) Zinc and cadmium in cell fractions of prostatic cancer tissue of different histological grading in comparison to BPH and normal prostate. Urol Res 12:147–150

    PubMed  CAS  Google Scholar 

  11. Saltzman BE, Gross SB, Yeager DW, Meiners BG, Gartside PS (1990) Total body burdens and tissue concentrations of lead, cadmium, copper, zinc, and ash in 55 human cadavers. Environ Res 52:126–145

    Article  PubMed  CAS  Google Scholar 

  12. Picurelli L, Olcina PV, Roig MD, Ferrer J (1991) Determination of Fe, Mg, Cu, and Zn in normal and pathological prostatic tissue. Actas Urol Esp 15:344–350

    PubMed  CAS  Google Scholar 

  13. Picurelli L, Olcina PV, Roig MD, Günthner S, Ferrer J (1991) Determination and relationship of the copper and zinc concentrations in normal and pathologic prostatic tissue. Trace Elem Med 8(3):131–137

    Google Scholar 

  14. Oldereid NB, Thomassen Y, Attramadal A, Olaisen B, Purvis K (1993) Concentrations of lead, cadmium and zinc in the tissues of reproductive organs of men. J Reprod Fertil 99:421–425

    Article  PubMed  CAS  Google Scholar 

  15. Schöpfer J, Drasch G, Schrauzer GN (2010) Selenium and cadmium levels and ratios in prostates, livers, and kidneys of nonsmokers and smokers. Biol Trace Elem Res 134:180–187

    Article  PubMed  Google Scholar 

  16. Zaichick V (2004) Losses of chemical elements in biological samples under the dry ashing process. Trace Elem Med 5(3):17–22 (Moscow)

    Google Scholar 

  17. Tipton IH, Cook MJ (1963) Trace elements in human tissue. Part II. Adult subjects from the United States. Health Phys 9:103–145

    Article  PubMed  CAS  Google Scholar 

  18. Stitch SR (1957) Trace elements in human tissue. I. A semi-quantitative spectrographic survey. Biochem J 67:97–103

    PubMed  CAS  Google Scholar 

  19. Tipton JH, Steiner RL, Foland WD, Mueller J, Stanley M (1954) USAEC-ORNL-Report-CF-54-12-66

  20. Jaritz M, Anke M, Holzinger S (1998) Der Bariumgehalt verschiedener Organe von Feldhase, Wildschwein, Damhirsch, Reh, Rothirsch, Mufflon and Mensch. In: Mengen- und Spurenelemente. 18. Arbeitstagung. Friedrich-Schiller-Universität, Jena, pp 467–474

  21. Kubo H, Hashimoto S, Ishibashi A, Chiba R, Yokota H (1976) Simultaneous determinations of Fe, Cu, Zn, and Br concentrations in human tissue sections. Med Phys 3:204–209

    Article  PubMed  CAS  Google Scholar 

  22. Zaichick S, Zaichick V (2011) The Br, Fe, Rb, Sr, and Zn content and interrelation in intact and morphologic normal prostate tissue of adult men investigated by energy dispersive X-ray fluorescent analysis. X-Ray Spectrom 40:464–469

    Article  CAS  Google Scholar 

  23. Holm W, Schneider H-J, Anke M (1971) Der Mineralstoffgehalt des Ejakulates und seine Beziehung zum Mengen- und Spurenelementgehalt von Prostate, Samenblase, Nebenhoden und Hoden. Arch Exp Vet Med 25:811–815

    CAS  Google Scholar 

  24. Tohno S, Kobayashi M, Shimizu H, Tohno Y, Suwannahoy P, Azuma C, Minami T, Sinthubua A, Mahakkanukrauh P (2009) Age-related changes of the concentrations of select elements in the prostates of Japanese. Biol Trace Elem Res 127:211–227

    Article  PubMed  CAS  Google Scholar 

  25. Naga Raju GJ, Sarita P, Ramana Murty GAV, Ravi Kumar M, Seetharami Reddy B, Lakshminarayana S, Prema Chand K, Durga Prasad A, Bhuloka Reddy S, Vijayan V, Rama Lakshmi PVB, Satyanarayana G (2007) Trace elemental analysis of normal, benign, hypertrophic and cancerous tissues of the prostate gland using the particle-induced X-ray emission technique. Eur J Cancer Prev 16:108–115

    Article  Google Scholar 

  26. Anspaugh LR, Robinson WL, Martin WH, Lowe OA (1973) Compilation of published information on elemental concentrations in human organs in both normal and diseased states. No. UCRL-51013Pt. 1971–1973, pp. 1–4

  27. Jafa A, Mahendra NM, Chowdhury AR, Kamboj VP (1980) Trace elements in prostatic tissue and plasma in prostatic diseases of man. Indian J Cancer 17:34–37

    PubMed  CAS  Google Scholar 

  28. Sangen H (1967) The influence of the trace metals upon the aconitase activity in human prostate glands. Jap J Urol 58:1146–1159

    PubMed  CAS  Google Scholar 

  29. Yamagata N (1962) The concentration of common cesium and rubidium in human body. J Radiat Res 3:9–30

    Article  PubMed  CAS  Google Scholar 

  30. Marezynska A, Kulpa J, Lenko J (1983) The concentration of zinc in relation to fundamental elements in the diseases human prostate. Int Urol Nephrol 15:257–265

    Article  Google Scholar 

  31. Schneider H-J, Anke M, Holm W (1970) The inorganic components of testicle, epididymis, seminal vesicle, prostate and ejaculate of young men. Int Urol Nephrol 2:419–427

    Article  CAS  Google Scholar 

  32. Forssen A (1972) Inorganic elements in the human body. I. Occurrence of Ba, Br, Ca, Cd, Cs, Cu, K, Mn, Ni, Sn, Sr, Y and Zn in the human body. Annales Medicinae Experimentalis et Biologie (Finland) 50:99–162

    CAS  Google Scholar 

  33. Soman SD, Joseph KT, Raut SJ, Mulay GD, Parameswaran M, Pandey VK (1970) Studies of major and trace element content in human tissues. Health Phys 19:641–656

    Article  PubMed  CAS  Google Scholar 

  34. Belt TH, Irwin D, King EJ (1936) Silicosis and dust deposits in the tissues of person without occupational exposure to siliceous dusts. Can Med Assoc J 34(2):125–133

    PubMed  CAS  Google Scholar 

  35. Iyengar GV (1998) Reevaluation of the trace element content in reference men. Radiat Phys Chem 51:545–560

    Article  CAS  Google Scholar 

  36. Iyengar GV, Kollmer WE, Bowen HGM (1978) The elemental composition of human tissues and body fluids. A compilation of values for adults. Verlag Chemie, Weinheim, 151 p

    Google Scholar 

  37. Györkey F, Min K-W, Huff JA, Györkey P (1967) Zinc and magnesium in human prostate gland: normal, hyperplastic, and neoplastic. Cancer Res 27:1349–1353

    Google Scholar 

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Acknowledgments

The authors are grateful to the late Prof. A.A. Zhavoronkov, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, for supplying prostate specimens. We are also grateful to Dr. Karandaschev V., Dr. Nosenko S., and Moskvina I., Institute of Microelectronics Technology and High Purity Materials, Chernogolovka, Russia, for their help in ICP-AES analysis.

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  1. Sofia Zaichick

    Present address: Department of Immunology and Microbiology, Northwestern University, 302 East Superior Street, Morton Building, Chicago, IL, 60640, USA

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  1. Radionuclide Diagnostics Department, Medical Radiological Research Centre, Korolyeva Str. 4, Obninsk, 249036, Kaluga Region, Russia

    Vladimir Zaichick & Sofia Zaichick

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  1. Vladimir Zaichick
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Correspondence to Vladimir Zaichick.

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Zaichick, V., Zaichick, S. NAA-SLR and ICP-AES Application in the Assessment of Mass Fraction of 19 Chemical Elements in Pediatric and Young Adult Prostate Glands. Biol Trace Elem Res 156, 357–366 (2013). https://doi.org/10.1007/s12011-013-9826-1

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