Calcium Fructoborate Helps Control Inflammation Associated with Diminished Bone Health


Inflammation has been identified as a possible contributory factor to disruption of the normal bone remodeling process, a process essential to healthy bone mineral density. Several large population-based clinical studies have specifically shown that levels of C-reactive protein, an immune recognition protein that is a sensitive marker of inflammation, are inversely and independently associated with total bone mineral density. The evidence suggests that control of C-reactive protein levels may contribute to bone health by protecting against inflammation’s disruption of the equilibrium between bone resorption and bone deposition. Calcium fructoborate, a patented complex of calcium, fructose, and boron found naturally in fresh and dried fruits, vegetables and herbs, and wine, is a sugar-borate ester. A growing body of peer-reviewed, published clinical research indicates that the calcium fructoborate significantly reduces serum levels of the C-reactive protein in humans, suggesting that this unique plant–mineral complex may contribute to bone health by controlling the inflammation associated with loss of bone mineral density.

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Fig. 1
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Fig. 3



Arachidonic acid


Alkaline phosphatase


Bone mineral density


Calcium fructoborate




C-reactive protein


Erythrocyte sedimentation rate




High-sensitivity C-reactive protein






Sugar-borate ester


Tumor necrosis factor-alfa


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This study was supported by Bioboron Research Institute from Craiova (Romania).

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The authors declare that they have no competing interests. The authors alone are responsible for the content and writing of this paper.

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Correspondence to Romulus Ion Scorei.

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All the authors contributed equally to this work.

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Scorei, I.D., Scorei, R.I. Calcium Fructoborate Helps Control Inflammation Associated with Diminished Bone Health. Biol Trace Elem Res 155, 315–321 (2013).

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  • Fructoborate
  • Boron
  • Inflammation
  • Bone health