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Calcium Fructoborate Helps Control Inflammation Associated with Diminished Bone Health

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Abstract

Inflammation has been identified as a possible contributory factor to disruption of the normal bone remodeling process, a process essential to healthy bone mineral density. Several large population-based clinical studies have specifically shown that levels of C-reactive protein, an immune recognition protein that is a sensitive marker of inflammation, are inversely and independently associated with total bone mineral density. The evidence suggests that control of C-reactive protein levels may contribute to bone health by protecting against inflammation’s disruption of the equilibrium between bone resorption and bone deposition. Calcium fructoborate, a patented complex of calcium, fructose, and boron found naturally in fresh and dried fruits, vegetables and herbs, and wine, is a sugar-borate ester. A growing body of peer-reviewed, published clinical research indicates that the calcium fructoborate significantly reduces serum levels of the C-reactive protein in humans, suggesting that this unique plant–mineral complex may contribute to bone health by controlling the inflammation associated with loss of bone mineral density.

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Abbreviations

AA:

Arachidonic acid

ALP:

Alkaline phosphatase

BMD:

Bone mineral density

CF:

Calcium fructoborate

COX-2:

Cyclooxygenase-2

CRP:

C-reactive protein

ESR:

Erythrocyte sedimentation rate

FBR:

Fibrinogen

hs-CRP:

High-sensitivity C-reactive protein

IL:

Interleukin

LPS:

Lipopolysaccharide

SBE:

Sugar-borate ester

TNF-alfa:

Tumor necrosis factor-alfa

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Acknowledgments

This study was supported by Bioboron Research Institute from Craiova (Romania).

Conflict of Interest

The authors declare that they have no competing interests. The authors alone are responsible for the content and writing of this paper.

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Authors and Affiliations

  1. Bioboron Research Institute, AI Cuza Street, No. 15, Craiova, Romania

    Iulia Daria Scorei

  2. University of Craiova, AI Cuza Street, No. 19, Craiova, Romania

    Romulus Ion Scorei

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  1. Iulia Daria Scorei
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  2. Romulus Ion Scorei
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Correspondence to Romulus Ion Scorei.

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All the authors contributed equally to this work.

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Scorei, I.D., Scorei, R.I. Calcium Fructoborate Helps Control Inflammation Associated with Diminished Bone Health. Biol Trace Elem Res 155, 315–321 (2013). https://doi.org/10.1007/s12011-013-9800-y

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