Abstract
Two structurally related vanadium(V) complexes, K3[VO2(C2O4)2]·3H2O and K3[VO(O2)(C2O4)2]·1/2H2O, were thoroughly characterized by infrared, Raman, and electronic spectroscopies. The effect of both complexes on the viability of the human MG-63 osteosarcoma cells was tested using the MTT assay. The monoperoxo complex shows a very strong antiproliferative activity (at 100-μM concentration, this complex diminished the cell viability ca. 80 %), whereas the dioxo complex was inactive.
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Acknowledgements
This work was supported by the Agencia Nacional de Promoción Cientifica y Tecnológica-ANPCyT (PICT 2218), by the Consejo Nacional de Investigaciones Científicas y Técnicas-CONICET (PIP 1125), and by the Universidad Nacional de La Plata (X-560 and X-554). IEL is a fellow from ANPCyT, and SBE and BSPC are members of the Research Career from CONICET.
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León, I.E., Etcheverry, S.B., Parajón-Costa, B.S. et al. Bis(oxalato)dioxovanadate(V) and Bis(oxalato)oxoperoxo-vanadate(V) Complexes: Spectroscopic Characterization and Biological Activity. Biol Trace Elem Res 155, 295–300 (2013). https://doi.org/10.1007/s12011-013-9787-4
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DOI: https://doi.org/10.1007/s12011-013-9787-4