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Hepatoprotective Effect of Manganese Chloride Against CCl4-Induced Liver Injury in Rats

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Abstract

The aim of the present study is to evaluate the protective effect of manganese chloride against carbon tetrachloride (CCl4)-induced liver injury in rats. Manganese chloride (0.001, 0.01, 0.05 and 0.1 g/kg bw) was administered intragastrically for 28 consecutive days to male CCl4-treated rats. The hepatoprotective activity was assessed using various biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-glutamyltransferase (GGT) and superoxide dismutase (SOD). Histopathological changes in the liver of different groups were also studied. Administration of CCl4 increased the serum ALT, AST, ALP and GGT but decreased SOD levels in rats. Treatment with manganese chloride significantly attenuated these changes to nearly normal levels. The animals treated with manganese chloride have shown decreased necrotic zones and hepatocellular degeneration when compared to the liver exposed to CCl4 intoxication alone. Thus, the histopathalogical studies also supported the protective effect of manganese chloride. Therefore, the results of this study suggest that manganese chloride exerts hepatoprotection via promoting antioxidative properties against CCl4-induced oxidative liver damage.

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Acknowledgment

We would like to thank Deputy Research of the Science and Research Branch, Islamic Azad University for the financial support of the project.

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Authors and Affiliations

  1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Akram Eidi, Khodabakhsh Behzadi & Ali Haeri Rohani

  2. Department of Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Pejman Mortazavi

  3. Department of Clinical Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Shahabeddin Safi

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  1. Akram Eidi
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Eidi, A., Mortazavi, P., Behzadi, K. et al. Hepatoprotective Effect of Manganese Chloride Against CCl4-Induced Liver Injury in Rats. Biol Trace Elem Res 155, 267–275 (2013). https://doi.org/10.1007/s12011-013-9784-7

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