Biological Trace Element Research

, Volume 155, Issue 2, pp 184–189 | Cite as

Blood Manganese Concentration is Elevated in Infants with Iron Deficiency

  • Sangkyu Park
  • Chang-Sun Sim
  • Heun Lee
  • Yangho KimEmail author


The present study was done to determine whether blood Mn concentration is elevated in iron-deficient infants. Thirty-one infants with iron deficiency and thirty-six control subjects (6–24 months of age) were tested for blood Mn concentration, complete blood counts, serum ferritin, and serum iron/transferring iron-binding capacity (Fe/TIBC). All the 31 iron-deficient infants were treated with iron supplement; however, 19 of them underwent blood Mn checkup again in compliance with follow-up schedule when their ferritin levels returned to the normal range. Iron therapies were done for 1–6 months (mean, 2.8; standard deviation, 1.6) using ferric hydroxide-polymaltose complex (6 mg/kg Fe3+ daily). Infants with iron deficiency had a higher mean blood Mn concentration than controls (2.550 vs. 1.499 μg/dL, respectively). After iron therapy, the blood Mn levels of iron-deficient infants significantly decreased compared to their pre-therapy levels (2.045 vs. 2.971 μg/dL, respectively), and their hemoglobin and ferritin levels significantly increased. After adjustment for covariates (e.g., age and breast-feeding), multiple linear regression models showed that increased blood Mn levels were significantly associated with low serum ferritin and hemoglobin levels, whereas with Fe/TIBC there was only a tendency. Our results indicate that iron deficiency increases blood Mn levels in infants, presumably by increasing Mn absorption.


Iron Deficiency Manganese Anemia 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Sangkyu Park
    • 1
  • Chang-Sun Sim
    • 2
  • Heun Lee
    • 2
  • Yangho Kim
    • 2
    Email author
  1. 1.Department of Pediatrics, Ulsan University HospitalUniversity of Ulsan College of MedicineUlsanSouth Korea
  2. 2.Department of Occupational and Environmental Medicine, Ulsan University HospitalUniversity of Ulsan College of MedicineUlsanSouth Korea

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