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Protective Effect of Edible Marine Algae, Laminaria japonica and Porphyra haitanensis, on Subchronic Toxicity in Rats Induced by Inorganic Arsenic

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Abstract

Arsenic, a potent environmental toxic agent, causes various hazardous effects on human health. This study was performed to evaluate the protective effects of edible marine algae, Laminaria japonica and Porphyra haitanensis, on subchronic stress of rats induced by arsenic trioxide (As2O3). The co-treatment of marine algae could slightly increase the growth rates of body weights compared to the As2O3-treated group. The marine algae application restored liver and renal function by preventing the increment in the activities of alanine transaminase and alkaline phosphatase, and the levels of total protein, blood urea nitrogen, and creatinine. The increase in the contents of total cholesterol, triglyceride, and low density lipoprotein cholesterol, and decrease in the contents of high density lipoprotein cholesterol were observed in algae co-treated groups which indicated that marine algae could reverse the abnormal lipid metabolisms induced by arsenic. Moreover, these algae could protect the rats from lipid peroxidation by restoring the depletion of superoxide dismutase and glutathione peroxidase activities and sulfhydryl group contents, and lowering the enhanced malondialdehyde contents. Therefore, evidences indicate that L. japonica and P. haitanensis can serve as an effective regimen for treating arsenic poisoning.

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Acknowledgments

The study was supported by the National Key Technologies R&D Program of China (no. 2012BAD28B05).

Conflict of Interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, 266071, People’s Republic of China

    Yanhua Jiang, Lianzhu Wang & Lin Yao

  2. Medical College, Qingdao University, Qingdao, 266021, People’s Republic of China

    Zhantao Liu & Hua Gao

Authors
  1. Yanhua Jiang
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  2. Lianzhu Wang
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  3. Lin Yao
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  4. Zhantao Liu
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  5. Hua Gao
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Correspondence to Lianzhu Wang.

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Jiang, Y., Wang, L., Yao, L. et al. Protective Effect of Edible Marine Algae, Laminaria japonica and Porphyra haitanensis, on Subchronic Toxicity in Rats Induced by Inorganic Arsenic. Biol Trace Elem Res 154, 379–386 (2013). https://doi.org/10.1007/s12011-013-9739-z

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  • DOI: https://doi.org/10.1007/s12011-013-9739-z

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