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The Acute and Chronic Effects of Monosodium l-Glutamate on Serum Iron and Total Iron-Binding Capacity in the Jugular Artery and Vein of Pigs

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Abstract

We analyzed the effects of acute and chronic oral administration of monosodium l-glutamate (MSG) on serum iron (Fe) levels and total iron-binding capacity (TIBC) in piglets. In the first experiment, 12 piglets were randomly assigned to two groups: one fed a standard diet (SD) and the other fed an SD containing MSG (10 g/kg). On day 30, serum, liver, kidney, and spleen samples were collected to determine the Fe levels. In the second experiment, six pigs were surgically fitted with a catheter in the jugular artery and vein to investigate the dynamic changes of serum Fe and TIBC. Blood samples were taken from each pig via the catheter every 30 min, for a period of 4 h. The results show that MSG increases Fe levels in the spleen (P < 0.05) and in serum obtained from the jugular artery (P < 0.01). In addition, TIBC in serum obtained from the jugular artery demonstrated an increasing trend in pigs fed the MSG diet; however, this trend was not observed in the jugular vein. In conclusion, MSG increases Fe retention by enhancing TIBC in serum.

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Acknowledgments

This research was jointly supported by grants from the Open Project Program of State Key Laboratory of Food Science and Technology, Nanchang University (no. SKLF-KF-201207; SKLF-KF-201005), National Key Technology Research and Development Program of the Ministry of Science and Technology of China (2012BAD39B00), the NSFC (31101730; 31110103909), Chinese Academy of Sciences and Knowledge Innovation Project (2012B091100259, 2012B091100210), and China Postdoctoral Science Foundation Funded Project (2012T50592; 20110491493).

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Authors and Affiliations

  1. State Key Laboratory of Food Science and Technology and College of Life Science and Food Engineering, Nanchang University, Nanchang, 330031, China

    Wu Xin, Shu Xugang, Jiangning Hu, Yu-long Yin & Ze-yuan Deng

  2. Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, 410125, China

    Wu Xin, Shu Xugang, Chunyan Xie, Jun Li & Yu-long Yin

Authors
  1. Wu Xin
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  2. Shu Xugang
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  3. Chunyan Xie
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  4. Jun Li
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  5. Jiangning Hu
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  6. Yu-long Yin
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  7. Ze-yuan Deng
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Correspondence to Yu-long Yin or Ze-yuan Deng.

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Shu Xugang and Chunyan Xie are equal contributors.

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Xin, W., Xugang, S., Xie, C. et al. The Acute and Chronic Effects of Monosodium l-Glutamate on Serum Iron and Total Iron-Binding Capacity in the Jugular Artery and Vein of Pigs. Biol Trace Elem Res 153, 191–195 (2013). https://doi.org/10.1007/s12011-013-9668-x

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  • DOI: https://doi.org/10.1007/s12011-013-9668-x

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