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Selenoprotein P and Yunnan Endemic Sudden Cardiac Death—an Ecological Study

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Abstract

The aim of the present study was to explore the role of selenoprotein P (SePP) in the etiology of the endemic sudden cardiac death in Yunnan, China. The levels of SePP of 124 subjects and glutathione peroxidase (GPx) of 119 subjects were measured. The subjects were from the old and new endemic areas and non-endemic areas. The levels of SePP and GPx of the subjects of the old endemic area were significantly higher than those of the subjects of the new endemic area and the non-endemic areas, respectively. The Pearson’s correlation among SePP, GPx, and the number of the incident cases of the disease were statistically significant. These correlations show that there is an inverse relationship among the number of patients and the levels of SePP (r  =  − 0.9800, P  =  0.0200) and GPx (r  =  − 0.961, P  =  0.009). The results show that selenium deficiency might play an important role in the incidence of the disease.

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Acknowledgments

This study was sponsored by China Natural Science Foundation Committee (30471497), The Ministry of Education Project for University Doctoral Degree Education (20050226003), and Team Innovation Fund of Harbin Medical University (2006). We would like to express our sincere acknowledgement to the local Centers for Disease Prevention and Control for coordinating the field work of this study.

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No potential conflict of interest was found.

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Authors and Affiliations

  1. Institute of Keshan Disease, Center for Endemic Disease Control, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China

    Q. Li, X. Z. Li, T. Wang, L. W. Zhou, H. Q. Feng, L. Gao, J. R. Pei & C. X. Jiang

  2. Harbin Medical University Cancer Hospital, Harbin, 150040, China

    Q. Li

  3. Department of Epidemiology, Jiamusi University, Jiamusi, 154007, China

    X. Z. Li

  4. National Key Laboratory of Molecular Oncology, Institute of Oncology, Union Medical College, Beijing, 100021, China

    C. Lin

  5. Department of Finance, Ministry of Health, 1 Xizhimengwai Nanlu, Beijing, 100044, China

    C. X. Jiang

Authors
  1. Q. Li
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  2. X. Z. Li
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  3. T. Wang
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  4. L. W. Zhou
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  5. H. Q. Feng
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  6. L. Gao
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  7. J. R. Pei
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  8. C. Lin
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  9. C. X. Jiang
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Corresponding author

Correspondence to T. Wang.

Additional information

Q Li and XZ Li contributed equally to this study.

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Li, Q., Li, X.Z., Wang, T. et al. Selenoprotein P and Yunnan Endemic Sudden Cardiac Death—an Ecological Study. Biol Trace Elem Res 151, 14–17 (2013). https://doi.org/10.1007/s12011-012-9530-6

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  • DOI: https://doi.org/10.1007/s12011-012-9530-6

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