Psoriasis is a chronic, immune-mediated skin disease characterized by production of reactive oxygen species due to the activation of tumor necrosis factor alpha (TNF-α), which is thought to be an important factor in inducing and maintaining psoriatic lesions. As an external factor, ultraviolet B (UVB) radiation stimulates TNF-α production and secretion by human keratinocytes in vitro and can also reach the upper dermis and suppress endothelial cells in vitro. The selenium level in psoriatic patients has been found to be lower than expected, but studies on its role in the pathogenesis of the disease are scarce. Selenium can influence immune response by changing the expression of cytokines and their receptors or by making immune cells more resistant to oxidative stress. It was reported that selenium supplementation had inhibitory effects on TNF-α levels in patients with psoriasis, but the details are not completely elucidated. Selenium compounds are also known to prevent the in vitro release of UVB-induced proinflammatory cytokines by inhibition of mRNA in human keratinocytes. In the present review, the protective role of selenium in oxidative stress, lesions, and immune system regulation in patients with psoriasis is summarized.
KeywordsSelenium Selenoprotein P Tumor necrosis factor alpha Oxidative stress Skin Psoriasis
Polyunsaturated fatty acids
Reactive oxygen species
Psoriasis area and severity index
There is no financial support in the current study.
Conflict of Interest
- 1.Abbari A, Johnson-Huang LM, Krueger JG (2011) Role of the immune system and immunological circuits in psoriasis. G Ital Dermatol Venereol 146:17–30Google Scholar
- 4.Kovacic P, Somanathan R (2008) Unifying mechanism for eye toxicity: electron transfer, reactive oxygen species, antioxidant benefits, cell signaling and cell membranes. Cell Membr Free Radic Res 2:56–69Google Scholar
- 7.Kökçam İ, Nazıroğlu M, Şimşek H, Aydilek N, Uyar B (1999) Antioxidant and lipid peroxidation status in the blood of patients with active vitiligo. Dermatosen Beruf Umwelt 47:102–105Google Scholar
- 20.Erturan I, Nazıroğlu M, Akkaya VB (2012) Isotretinoin treatment induces oxidative toxicity in blood of patients with acne vulgaris: a clinical pilot study. Cell Biochem Funct (Epub of print)Google Scholar
- 33.Michaelson G, Berne B, Carlmark B, Strand A (1989) Selenium in whole blood and plasma is decreased in patients with moderate and severe psoriasis. Acta Derm Venereol 69:29–34Google Scholar
- 44.Fairris GM, Perkins PJ, Lawson AD, Blake GM (1988) The pharmacokinetics of selenium in psoriasis and atopic dermatitis. 68:434–436Google Scholar
- 46.Pastore S, Mariani V, Lulli D, et al (2011) Glutathione peroxidase activity in the blood cells of psoriatic patients correlates with their responsiveness to Efalizumab. 45:585–599Google Scholar