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Biological Trace Element Research

, Volume 150, Issue 1–3, pp 3–9 | Cite as

Selenium and Psoriasis

  • Mustafa Nazıroğlu
  • Kevser Yıldız
  • Burcu Tamtürk
  • İjlal Erturan
  • Manuel Flores-Arce
Article

Abstract

Psoriasis is a chronic, immune-mediated skin disease characterized by production of reactive oxygen species due to the activation of tumor necrosis factor alpha (TNF-α), which is thought to be an important factor in inducing and maintaining psoriatic lesions. As an external factor, ultraviolet B (UVB) radiation stimulates TNF-α production and secretion by human keratinocytes in vitro and can also reach the upper dermis and suppress endothelial cells in vitro. The selenium level in psoriatic patients has been found to be lower than expected, but studies on its role in the pathogenesis of the disease are scarce. Selenium can influence immune response by changing the expression of cytokines and their receptors or by making immune cells more resistant to oxidative stress. It was reported that selenium supplementation had inhibitory effects on TNF-α levels in patients with psoriasis, but the details are not completely elucidated. Selenium compounds are also known to prevent the in vitro release of UVB-induced proinflammatory cytokines by inhibition of mRNA in human keratinocytes. In the present review, the protective role of selenium in oxidative stress, lesions, and immune system regulation in patients with psoriasis is summarized.

Keywords

Selenium Selenoprotein P Tumor necrosis factor alpha Oxidative stress Skin Psoriasis 

Abbreviations

GSH-Px

Glutathione peroxidase

GSH

Glutathione

PUFAs

Polyunsaturated fatty acids

ROS

Reactive oxygen species

SOD

Superoxide dismutase

MDA

Malondialdehyde

PASI

Psoriasis area and severity index

Notes

Acknowledgments

There is no financial support in the current study.

Conflict of Interest

None.

References

  1. 1.
    Abbari A, Johnson-Huang LM, Krueger JG (2011) Role of the immune system and immunological circuits in psoriasis. G Ital Dermatol Venereol 146:17–30Google Scholar
  2. 2.
    Ricketts JR, Rothe MJ, Grant-Kels JM (2010) Nutrition and psoriasis. Clin Dermatol 28:615–626PubMedCrossRefGoogle Scholar
  3. 3.
    Serwin AB, Wasowicz W, Gromadziska J, Chodynicka B (2003) Selenium status in psoriasis and its relationship with alcohol consumption. Nutrition 19:301–304PubMedCrossRefGoogle Scholar
  4. 4.
    Kovacic P, Somanathan R (2008) Unifying mechanism for eye toxicity: electron transfer, reactive oxygen species, antioxidant benefits, cell signaling and cell membranes. Cell Membr Free Radic Res 2:56–69Google Scholar
  5. 5.
    Okayama Y (2005) Oxidative stress in allergic and inflammatory skin diseases. Curr Drug Targets Inflamm Allergy 4:517–519PubMedCrossRefGoogle Scholar
  6. 6.
    Kökçam I, Naziroğlu M (1999) Antioxidants and lipid peroxidation status in the blood of patients with psoriasis. Clin Chim Acta 289:23–31PubMedCrossRefGoogle Scholar
  7. 7.
    Kökçam İ, Nazıroğlu M, Şimşek H, Aydilek N, Uyar B (1999) Antioxidant and lipid peroxidation status in the blood of patients with active vitiligo. Dermatosen Beruf Umwelt 47:102–105Google Scholar
  8. 8.
    Naziroğlu M, Kökçam I, Simşek H, Karakilçik AZ (2003) Lipid peroxidation and antioxidants in plasma and red blood cells from patients with pemphigus vulgaris. J Basic Clin Physiol Pharmacol 14:31–42PubMedGoogle Scholar
  9. 9.
    Abdel Fattah NS, Ebrahim AA, El Okda ES (2011) Lipid peroxidation/antioxidant activity in patients with alopecia areata. J Eur Acad Dermatol Venereol 25:403–408PubMedCrossRefGoogle Scholar
  10. 10.
    Sanmartin C, Plano D, Font M, Palop JA (2011) Selenium and clinical trials: new therapeutic evidence for multiple diseases. Curr Med Chem 18:4635–4650PubMedCrossRefGoogle Scholar
  11. 11.
    Nazıroglu M (2009) Role of selenium on calcium signaling and oxidative stress-induced selenium compounds have molecular pathways in epilepsy. Neurochem Res 34:2181–2191PubMedCrossRefGoogle Scholar
  12. 12.
    Stewart MS, Spallholz JE, Neldner KH, Pence BC (1999) Disparate abilities to impose oxidative stress and induce apoptosis. Free Radic Biol Med 26:42–48PubMedCrossRefGoogle Scholar
  13. 13.
    Song H, Kim J, Lee HK, Park HJ, Nam J, Park GB, Kim YS, Cho D, Hur DY (2011) Selenium inhibits migration of murine melanoma cells via down-modulation of IL-18 expression. Int Immunopharmacol 11:2208–2213PubMedCrossRefGoogle Scholar
  14. 14.
    Saral Y, Uyar B, Ayar A, Naziroglu M (2002) Protective effects of topical alpha-tocopherol acetate on UVB irradiation in guinea pigs: importance of free radicals. Physiol Res 51:285–290PubMedGoogle Scholar
  15. 15.
    Nathan C, Xie OW (1994) Regulation of biosynthesis of nitric oxide. J Biol Chem 269:13725–13728PubMedGoogle Scholar
  16. 16.
    Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science 179:588–590PubMedCrossRefGoogle Scholar
  17. 17.
    Harvima RJ, Jägerroos H, Kajander EO et al (1993) Screening of effects of selenomethionine-enriched yeast supplementation on various immunological and chemical parameters of skin and blood in psoriatic patients. Acta Derm Venereol 73:88–91PubMedGoogle Scholar
  18. 18.
    Serwin AB, Chodynicka B, Wasowicz W, Gromadzińska J (1999) Selenium nutritional status and the course of psoriasis. Pol Merkur Lekarski 6:263–265PubMedGoogle Scholar
  19. 19.
    Sahin M, Uğuz AC, Demirkan H, Nazıroğlu M (2011) Colchicine modulates oxidative stress in serum and leucocytes from remission patients with family Mediterranean fever through regulation of Ca² + release and the antioxidant system. J Membr Biol 240:55–62PubMedCrossRefGoogle Scholar
  20. 20.
    Erturan I, Nazıroğlu M, Akkaya VB (2012) Isotretinoin treatment induces oxidative toxicity in blood of patients with acne vulgaris: a clinical pilot study. Cell Biochem Funct (Epub of print)Google Scholar
  21. 21.
    Nazıroğlu M (2012) Molecular role of catalase on oxidative stress-induced Ca+2 signaling and TRP cation channel activation in nervous system. J Recept Signal Transduct Res 32:134–141PubMedCrossRefGoogle Scholar
  22. 22.
    Sibille Y, Reynolds HY (1990) Macrophages and polymorphonuclear neutrophils in lung defense and injury. Am Rev Respir Dis 141:471–501PubMedGoogle Scholar
  23. 23.
    Weening RS, Roos D, Loos JA (1974) Oxygen consumption of phagocytizing cells in human leukocyte and granulocyte preparations: a comparative study. J Lab Clin Med 83:570–577PubMedGoogle Scholar
  24. 24.
    Bréchard S, Tschirhart EJ (2008) Regulation of superoxide production in neutrophils: role of calcium influx. J Leukoc Biol 84:1223–1237PubMedCrossRefGoogle Scholar
  25. 25.
    Whiteman M, Rose P, Halliwell B (2003) Inhibition of hypochlorous acid-induced oxidative reactions by nitrite: is nitrite an antioxidant. Biochem Biophys Res Commun 303:1217–1224PubMedCrossRefGoogle Scholar
  26. 26.
    Halliwell B (2006) Phagocyte-derived reactive species: salvation or suicide. Trends Biochem Sci 31:509–515PubMedCrossRefGoogle Scholar
  27. 27.
    Azzini M, Girelli D, Oliveri O et al (1995) Fatty acids and antioxidant micronutrients in psoriatic arthritis. J Rheumatol 22:103–108PubMedGoogle Scholar
  28. 28.
    Serwin AB, Wasowicz W, Gromadzinska J, Chodynicka B (2003) Selenium status in psoriasis and its relationship with the severity of the disease. Nutrition 19:301–304PubMedCrossRefGoogle Scholar
  29. 29.
    Pinton J, Friden H, Kettaneh-Wold N, Wold S, Dreno B, Richard A, Bieber T (1995) Clinical and biological effects of balneotherapy with selenium-rich spa water in patients with psoriasis vulgaris. Br J Derm 133:344–347CrossRefGoogle Scholar
  30. 30.
    Brozmanová J, Mániková D, Vlčková V, Chovanec M (2010) Selenium: a double-edged sword for defense and offence in cancer. Arch Toxicol 84:919–938PubMedCrossRefGoogle Scholar
  31. 31.
    Pighetti GM, Eskew ML, Reddy CC, Sordillo LM (1998) Selenium and vitamin E deficiency impair transferrin receptor internalization but not IL-2, IL-2 receptor, or transferrin receptor expression. J Leukoc Biol 63:131–137PubMedGoogle Scholar
  32. 32.
    Celerier P, Richard A, Litoux P, Dreno B (1995) Modulatory effects of selenium and strontium salts on keratinocyte-derived inflammatory cytokines. Arch Dermatol Res 287:680–682PubMedCrossRefGoogle Scholar
  33. 33.
    Michaelson G, Berne B, Carlmark B, Strand A (1989) Selenium in whole blood and plasma is decreased in patients with moderate and severe psoriasis. Acta Derm Venereol 69:29–34Google Scholar
  34. 34.
    Serwin AB, Mysliwiec H, Hukalowic K et al (2003) Soluble tumor necrosis factor-alpha receptor type 1 during selenium supplementation in psoriasis patients. Nutrition 19:847–850PubMedCrossRefGoogle Scholar
  35. 35.
    DeSilva B, Beckett GJ, McLean S, Arthur JR, Hunter JA, Norval M, McKenzie RC (2007) Lack of effect of oral selenite on p53 associated gene expression during TL01 therapy of psoriasis patients. Photodermatol Photoimmunol Photomed 23:98–100PubMedCrossRefGoogle Scholar
  36. 36.
    Kadry D, Rashed L (2012) Plasma and tissue osteopontin in relation to plasma selenium in patients with psoriasis. J Eur Acad Dermatol Venereol 26:66–70PubMedCrossRefGoogle Scholar
  37. 37.
    Serwin AB, Wasowicz W, Chodynicka B (2006) Selenium supplementation, soluble tumor necrosis factor-alpha receptor type 1, and C-reactive protein during psoriasis therapy with narrowband ultraviolet B. Nutrition 22:860–864PubMedCrossRefGoogle Scholar
  38. 38.
    McKenzie RC (2000) Selenium ultraviolet radiation and the skin. Clin Exp Dermatol 25:631–636PubMedCrossRefGoogle Scholar
  39. 39.
    Rafferty TS, Walker C, Hunter JAA, Beckett GJ, McKenzie RC (2002) Inhibition of ultraviolet B radiation-induced interleukin 10 expression in murine keratinocytes by selenium compounds. Br J Dermatol 146:485–489PubMedCrossRefGoogle Scholar
  40. 40.
    Rocha-Pereira P, Santos-Silva A, Rebelo I, Figueiredo A, Quintanilha A, Teixeira F (2004) The inflammatory response in mild and in severe psoriasis. Br J Dermatol 150:917–928PubMedCrossRefGoogle Scholar
  41. 41.
    Xun P, Liu K, Morris JS et al (2010) Associations of toenail selenium levels with inflammatory biomarkers of fibrinogen, high-sensitivity C-reactive protein, and interleukin-6: the CARDIA Trace Element Study. Am J Epidemiol 171:793–800PubMedCrossRefGoogle Scholar
  42. 42.
    McLoone P, Man I, Yule S et al (2004) Whole-body UVB (TL-01) or UVA-1 irradiation does not alter the levels of immunomodulatory cytokines in the serum of human volunteers. Photodermatol Photoimmunol Photomed 20:76–80PubMedCrossRefGoogle Scholar
  43. 43.
    Donadini A, Fiora C, Regazzini R, Perini D, Minoia C (1992) Selenium plasma levels in psoriasis. Clin Exp Dermatol 17:214–216PubMedCrossRefGoogle Scholar
  44. 44.
    Fairris GM, Perkins PJ, Lawson AD, Blake GM (1988) The pharmacokinetics of selenium in psoriasis and atopic dermatitis. 68:434–436Google Scholar
  45. 45.
    Clark LC, Hixson LJ, Combs GF Jr, Reid ME, Turnbull BW, Sampliner RE (1993) Plasma selenium concentration predicts the prevalence of colorectal adenomatous polyps. Cancer Epidemiol Biomarkers Prev 2:41–46PubMedGoogle Scholar
  46. 46.
    Pastore S, Mariani V, Lulli D, et al (2011) Glutathione peroxidase activity in the blood cells of psoriatic patients correlates with their responsiveness to Efalizumab. 45:585–599Google Scholar
  47. 47.
    Fairris GM, Lloyd B, Hinks L, Perkins PJ, Clayton BE (1989) The effect of supplementation with selenium and vitamin E in psoriasis. Ann Clin Biochem 26:83–88PubMedGoogle Scholar
  48. 48.
    Kharaeva Z, Gostova E, De Luca C, Raskovic D, Korkina L (2009) Clinical and biochemical effects of coenzyme Q10, vitamin E, and selenium supplementation to psoriasis patients. Nutrition 25:295–302PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Mustafa Nazıroğlu
    • 1
  • Kevser Yıldız
    • 2
  • Burcu Tamtürk
    • 2
  • İjlal Erturan
    • 3
  • Manuel Flores-Arce
    • 4
  1. 1.Department of Biophysics, Medical FacultySüleyman Demirel UniversityCünürTurkey
  2. 2.Student, Medical FacultySüleyman Demirel UniversityIspartaTurkey
  3. 3.Department of Dermatology, Medical FacultySuleyman Demirel UniversityIspartaTurkey
  4. 4.Department of Chemical and Biochemical EngineeringTijuana Institute of TechnologyTijuanaMexico

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