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Protection of Selenium on Hepatic Mitochondrial Respiratory Control Ratio and Respiratory Chain Complex Activities in Ducklings Intoxicated with Aflatoxin B1

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Abstract

To investigate the protection of selenium on hepatic mitochondrial functions, 90 7-day-old ducklings were randomly divided into three groups (groups I–III). Group I was used as a blank control. Group II was administered with aflatoxin B1 (0.1 mg/kg body weight). Group III was administered with aflatoxin B1 (0.1 mg/kg body weight) plus selenium (sodium selenite, 1 mg/kg body weight). All treatments were given once daily for 21 days. The results showed that the activities of hepatic mitochondrial complexes I–IV in group II ducklings significantly decreased when compared with group I (P < 0.01). Furthermore, the activities of hepatic mitochondrial complexes I–IV in group III significantly increased when compared with group II (P < 0.05). The hepatic mitochondrial respiratory control ratio (RCR) in group II ducklings significantly decreased when compared with group I (P < 0.01). In addition, the hepatic mitochondrial RCR in group III significantly increased when compared with group II (P < 0.05). These results revealed that the aflatoxin B1 significantly induced hepatic mitochondrial dysfunction in the activities of hepatic mitochondrial respiratory chain complexes I–IV and the RCR in ducklings. However, sodium selenite could significantly ameliorate the negative effect induced by aflatoxin B1.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (grant no. 38071900).

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Authors and Affiliations

  1. College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China

    Dayou Shi, Shining Guo, Rongsheng Su, Mingsheng Guo, Nian Liu, Pengfei Li & Zhaoxin Tang

  2. Institute of Veterinary Medicine, Guangdong Academy of Agricultural Sciences, Guangzhou, 510640, China

    Shenquan Liao

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  1. Dayou Shi
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  2. Shining Guo
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  3. Shenquan Liao
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  4. Rongsheng Su
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  5. Mingsheng Guo
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  6. Nian Liu
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  7. Pengfei Li
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  8. Zhaoxin Tang
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Corresponding author

Correspondence to Zhaoxin Tang.

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Dayou Shi, Shining Guo, and Shenquan Liao contributed equally to this work.

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Shi, D., Guo, S., Liao, S. et al. Protection of Selenium on Hepatic Mitochondrial Respiratory Control Ratio and Respiratory Chain Complex Activities in Ducklings Intoxicated with Aflatoxin B1 . Biol Trace Elem Res 145, 312–317 (2012). https://doi.org/10.1007/s12011-011-9195-6

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  • DOI: https://doi.org/10.1007/s12011-011-9195-6

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