Protective Effects of Curcumin against Sodium Fluoride-Induced Toxicity in Rat Kidneys


In the present study, the protective effect of curcumin against sodium fluoride-induced nephrotoxicity was evaluated in rats. Renal injury was induced by daily administration of 600 ppm sodium fluoride in drinking water for 1 week. One week before the administration of fluoride, the animals selected as study group were given curcumin (10 and 20 mg/kg body weight, intraperitoneally). After 1 week, lipid peroxidation level, activities of superoxide dismutase, catalase, and level of glutathione in kidney homogenate were measured. Blood serum samples were examined for creatinine, serum urea, and blood urea nitrogen levels. Another group of rats received vitamin C (10 mg/kg) as standard antioxidant. The results show that curcumin and vitamin C treatment prior to fluoride administration normalized the levels of serum creatinine, serum urea, and blood urea nitrogen. Moreover, curcumin and vitamin C administrations prevented the antioxidant enzyme decreasing and lipid peroxidation levels imbalance. In conclusion, curcumin treatment at the doses of 10 and 20 mg/kg (intraperitoneally) showed significant nephroprotective effects.

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Reduced glutathione


Sodium fluoride


Trichloro acetic acid


Thiobarbituric acid


Bovine serum albumin


Blood urea nitrogen






Superoxide dismutase


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The authors acknowledge the financial support of the National Elite’s Foundation of Iran (Tehran, Iran-grant No. Nabavi2009). We would like to thank Dr. Ali Roohbakhsh for English language editing. This paper is dedicated to Mrs. Seyed Maryam Nabavi and with the memory of Mr. Seyed Ali Asghar Nabavi.

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Correspondence to Seyed Mohammad Nabavi.

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Nabavi, S.F., Moghaddam, A.H., Eslami, S. et al. Protective Effects of Curcumin against Sodium Fluoride-Induced Toxicity in Rat Kidneys. Biol Trace Elem Res 145, 369–374 (2012).

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  • Oxidative stress
  • Creatinine
  • Serum urea
  • SOD