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The Effects of Physical Exercise on the Serum Iron Profile in Spontaneously Hypertensive Rats

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Abstract

The purpose of this study was to evaluate the profile of serum iron in spontaneously hypertensive rats after an aerobic physical exercise. To accomplish this, 12 normotensive Wistar rats and 12 spontaneously hypertensive rats were distributed into “physical exercise” and “no physical exercise” groups. The animals in the physical exercise group underwent to an aerobic exercise for a total of 4 weeks. Blood was collected for the analysis of iron. Our results indicate that rats of the physical exercise group had significantly lower serum iron levels after the aerobic exercise protocol compared to the spontaneously hypertensive rats no physical exercise group (F (3,16) = 4.4915, p < 0.01). No significant difference was found between no physical exercise groups. The results indicated that the difference in iron may be due to an increased demand for iron, prompted by chronic physical exercise. In addition, erythrocytosis has been associated with increased blood pressure in spontaneously hypertensive rats, suggesting that iron reduction may be related to decreased blood pressure in these animals.

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Acknowledgments

This work was supported by grants from AFIP, FAPESP (no. 08/50646-6 to AME and CEPID no. 98/14303-3 to ST), CEPE, and CEMSA. MTM and ST are recipients of the CNPq fellowship.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Departamento de Psicobiologia, Universidade Federal de São Paulo, Rua Prof. Francisco de Castro, 93, Vila Clementino, São Paulo, São Paulo, Brazil

    Miriam K. Frank, Andrea Maculano Esteves, Cleide Lopes, Daniel A. Cavagnolli, Sergio Tufik & Marco Tulio de Mello

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  1. Miriam K. Frank
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  2. Andrea Maculano Esteves
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  3. Cleide Lopes
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  4. Daniel A. Cavagnolli
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  5. Sergio Tufik
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  6. Marco Tulio de Mello
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Corresponding authors

Correspondence to Miriam K. Frank or Andrea Maculano Esteves.

Additional information

Miriam K. Frank and Andrea M. Esteves had the same contribution to this study.

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Frank, M.K., Esteves, A.M., Lopes, C. et al. The Effects of Physical Exercise on the Serum Iron Profile in Spontaneously Hypertensive Rats. Biol Trace Elem Res 145, 222–224 (2012). https://doi.org/10.1007/s12011-011-9188-5

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  • DOI: https://doi.org/10.1007/s12011-011-9188-5

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