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Biological Trace Element Research

, Volume 145, Issue 1, pp 81–86 | Cite as

Bioaccessibility and Risk Assessment of Cadmium from Uncooked Rice Using an In Vitro Digestion Model

  • Lin-Sheng Yang
  • Xiu-Wu ZhangEmail author
  • Yong-Hua LiEmail author
  • Hai-Rong Li
  • Ying Wang
  • Wu-Yi Wang
Article

Abstract

Cadmium (Cd)-contaminated rice is one of the most important sources of cadmium exposure in the general population from some Asian countries. This study was conducted to assess cadmium exposure from uncooked rice in rural mining areas based on the bioaccessible fraction of cadmium using an in vitro digestion model. The biotoxic effects of cadmium in uncooked rice from mining areas were much higher than those in the control area, based not only on their higher total concentration (52.49 vs. 7.93 μg kg−1), but also on their higher bioaccessibility (16.94% vs. 2.38%). In the mining areas, the bioaccessible fraction of cadmium in uncooked rice has a significant positive correlation with the total concentration of cadmium in rice and there was quarterly unsafe rice to the public in the mining areas. The results indicated that the in vitro digestion model could be a useful and economical tool for providing the solubilization or bioaccessibility of uncooked rice in the mining area. The results could be helpful in conducting future experiments of cooked rice in the vitro model.

Keywords

Cadmium Bioaccessibility In vitro Risk assessment Human health 

Notes

Acknowledgments

Financial support was provided by the Natural Science Foundation of China (41040014; 40571008), National Key Technology R&D Program of China (2007BAC03A11-07), the Knowledge Innovation Foundation of the IGSNRR (200906002), and the SSRC Collaborative Grants Program supported by the Rockefeller Brothers Fund. The authors would like to thank Dr. Jennifer Holdaway from SSRC for proof reading the final manuscript.

References

  1. 1.
    WHO (1992) International programme on chemical safety, Environment Health criteria, No. 134. Cadmium, GenevaGoogle Scholar
  2. 2.
    WHO (1993) Cadmium and certain cadmium products; IARC Monographs; International Agency for Research on Cancer: Lyon, France, 58:119–146, 210–236. Geneva, Switzerland, available in the: http://www.who.int
  3. 3.
    Singh BR, Mclaughlin MJ (1999) Cadmium in soils and plants. In: Mclaughlin MJ, Singh BR (eds) Developments in plant and soil sciences, vol 85. Kluwer Academic Publishers, Dordrecht, pp 257–268Google Scholar
  4. 4.
    Clemens S (2006) Toxic metal accumulation, responses to exposure and mechanisms of tolerance in plants. Biochimie 88:1717–1719CrossRefGoogle Scholar
  5. 5.
    Franz E, Romkens P, van Raamsdonk L, van der Fels-Klerx I (2008) A chain modeling approach to estimate the impact of soil cadmium pollution on human dietary exposure. J Food Prot 71:2504–2513PubMedGoogle Scholar
  6. 6.
    Nogawa K, Kobayashi E, Okubo Y, Suwazono Y (2004) Environmental cadmium exposure, adverse effects, and preventative measures in Japan. Biometals 17:581–587PubMedCrossRefGoogle Scholar
  7. 7.
    Friberg L, Piscator M, Nordberg GF, Kjellstrom T (1974) Cadmium in the environment. 2nd ed. CRC Press, Cleveland, p 94Google Scholar
  8. 8.
    Ohta H, Cherian MG (1995) The influence of nutritional deficiencies on gastrointestinal uptake of cadmium and cadmium-metallothionein in rats. Toxicology 97:71–80PubMedCrossRefGoogle Scholar
  9. 9.
    Kawada T, Suzuki S (1998) A review on the cadmium content of rice, daily cadmium intake, and accumulation in the kidneys. J Occup Health 40:264–269CrossRefGoogle Scholar
  10. 10.
    Ruby MV, Schoof R, Brattin W, Goldade M, Post G, Harnois M, Mosby DE, Casteel SW, Berti W, Carpenter M (1999) Advances in evaluating the oral bioavailability of inorganic in soil for use in human health risk assessment. Environ Sci Technol 33:3697–3705CrossRefGoogle Scholar
  11. 11.
    Versantvoort CHM, Oomen AG, Kamp EV, Rompelberg CJM, Sips AJAM (2005) Applicability of an in vitro digestion model in assessing the bioaccessibility of mycotoxins from food. Food Chem Toxicol 43:31–40PubMedCrossRefGoogle Scholar
  12. 12.
    Oomen AG, Hack A, Minekus M, Zeijdner E, Cornelis C, Schoeters G, Verstraete W, van de Wiele T, Wragg J, Rompelberg CJM, Sips AJAM, van Wijnen JH (2002) Comparison of five in vitro digestion models to study the bioaccessibility of soil contaminants. Environ Sci Technol 36:3326–3334PubMedCrossRefGoogle Scholar
  13. 13.
    Oomen AG, Rompelberg CJM, Bruil MA, Dobbe CJG, Pereboom DPKH, Sips AJAM (2003) Development of an in vitro digestion model for estimation the bioaccessibility of soil contaminants. Arch Environ Contam Toxicol 44:281–287PubMedCrossRefGoogle Scholar
  14. 14.
    Laparra JM, Veiez D, Montoro R, Barbera R, Farre R (2003) Estimation of arsenic bioaccessibility in edible seaweed by an in vitro digestion method. J Agric Food Chem 51:6080–6085PubMedCrossRefGoogle Scholar
  15. 15.
    Brandon EFA, Oomen AG, Rompelberg CJM, Versantvoot CHM, Engelen JGM, Sips AJAM (2006) Consumer product in vitro digestion model: Bioaccessibility of contaminants and its application in risk assessment. Regul Toxicol Pharm 44:161–171CrossRefGoogle Scholar
  16. 16.
    White DA, Fisk ID, Makkhun S, Gray DA (2009) In vitro assessment of the bioaccessibility of tocopherol and fatty acids form sunflower seed oil bodies. J Agric Food Chem 57:5720–5726PubMedCrossRefGoogle Scholar
  17. 17.
    Yang DH, Lee YJ (2009) Determination of cadmium bioaccessibility in herbal medicines and safety assessment by in vitro dissolution and ICP-AES. Microchim Acta 167:117–122CrossRefGoogle Scholar
  18. 18.
    Wang J, Lu D, Chen SY (1994) Effects of environmental pollution on human health in lead/zinc mine of Fenghuang, Hunan province. Chin J Public Health 10:21–122Google Scholar
  19. 19.
    Li YY, Wang WY, Yang LS, Li HR (2005) Environmental quality of soil polluted by mercury and lead in polymetallic deposit areas of western Hunan Province. Environ Sci 26:187–191Google Scholar
  20. 20.
    Sun HF, Li YH, Ji YF, Yang LS, Wang WY, Li HR (2010) Environmental contamination and health hazard of lead and cadmium around Chatian mercury mining deposit in western Hunan Province, China. Trans Nonfer Metals Society China 20:308–314CrossRefGoogle Scholar
  21. 21.
    Zhang XW, Li YH, Yang LS, Li HR, Wang WY (2010) Determination of five trace elements in human whole blood by temperature-controllable wet digestion and ICP-MS technique. Spectroscopy Spectral Anal 30:1972–1974Google Scholar
  22. 22.
    Versantvoort CHM, Van de Kamp E, Rompelberg CJM (2004) Development and applicability of an in vitro digestion model in assessing the bioaccessibility of contaminants from food. Report no. 320102002, Available from <http:/www.rivm.nl/en/>, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
  23. 23.
    Wang ZS, Duan XL, Liu P, Niu J, Huang N, Zhang JL (2009) Human exposure factors of Chinese people in environmental health risk assessment. Res Environ Sci 22:1164–1170Google Scholar
  24. 24.
    Xiao JF (2007) Analysis of dietary structure and nutrient intake status of adult of Hunan Province. Dissertation, Central South UniversityGoogle Scholar
  25. 25.
    Fernandez-Garcia E, Carvajal-Lerida I, Perez-Galvez A (2009) In vitro bioaccessibility assessment as a prediction tool of nutritional efficiency. Nutr Res 29:751–760PubMedCrossRefGoogle Scholar
  26. 26.
    Kobayashi E, Suwazono Y (2009) Estimation of benchmark rice cadmium doses as threshold values for abnormal urinary findings with adjustment for consumption of Jinzu River water. Bull Environ Contam Toxicol 83:102–107PubMedCrossRefGoogle Scholar
  27. 27.
    Cai S, Yue L, Shang Q, Nordberg G (1995) Cadmium exposure among residents in an area contaminated by irrigation water in China. Bull World Health Organ 73:359–367PubMedGoogle Scholar
  28. 28.
    Amiard JC, Amiard-Triquet C, Charbonnier L, Mesnil A, Rainbow PS, Wang WX (2008) Bioaccessibility of essential and non-essential metals in commercial shellfish from Western Europe and Asia. Food Chem Toxicol 46:2010–2022PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Institute of Geographical Sciences and Natural Resources ResearchChinese Academy of SciencesBeijingChina
  2. 2.Graduate University of Chinese Academy of SciencesBeijingChina
  3. 3.College of Life Science and TechnologyJinan UniversityGuangzhouChina
  4. 4.Research Center for Environment Change and HealthInstitute of Geographical Sciences and Natural Resources Research, Chinese Academy of SciencesBeijingChina

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