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The Relationship Between Serum Selenium Concentration and Neutrophil Function in Peripheral Blood

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Abstract

We evaluated the relationships between neutrophil-related functions and serum selenium (Se) concentration in the general population. We examined 800 subjects who had participated in the Iwaki Health Promotion Project in 2005 to determine the relationships between serum Se concentration and neutrophil-related functions such as the production capability of reactive oxygen species (ROS), phagocytic activity, and serum opsonic activity (SOA). In nonstimulated neutrophils, i.e., in neutrophils at their baseline condition before the application of the phagocytic stimulus, the serum Se concentration tends to be high and the ROS production tends to be low. With regard to SOA, there was a significant negative correlation between lucigenin-dependent chemiluminescence and serum Se concentration in both men and women. Moreover, in women, a significant negative correlation was observed between luminol-dependent chemiluminescence and serum Se concentration. These results suggest that subjects with a lower serum Se concentration may be exposed to a greater chronic oxidative stress due to neutrophil ROS production. In addition, the findings of our study suggest that women rather than men benefit more from Se against oxidative stress.

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Authors and Affiliations

  1. Department of Social Medicine, Hirosaki University Graduate School of Medicine, Zaifu-cho 5, Hirosaki, 036-8562, Aomori, Japan

    Sangun Lee, Ippei Takahashi, Masashi Matsuzaka, Kiyonori Yamai, Kazuma Danjo, Takako Kumagai, Takashi Umeda & Shigeyuki Nakaji

  2. Department of Physical Therapy, Aomori University of Health and Welfare, Hamadate Mase 58-1, Aomori, 030-8505, Aomori, Japan

    Sangun Lee

  3. Department of Hygiene and preventive Medicine, Iwate Medical University, Utimaru 19-1, Morioka, 020-8505, Iwate, Japan

    Kazuyoshi Itai

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  1. Sangun Lee
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  2. Ippei Takahashi
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  4. Kiyonori Yamai
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  9. Shigeyuki Nakaji
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Correspondence to Ippei Takahashi.

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Lee, S., Takahashi, I., Matsuzaka, M. et al. The Relationship Between Serum Selenium Concentration and Neutrophil Function in Peripheral Blood. Biol Trace Elem Res 144, 396–406 (2011). https://doi.org/10.1007/s12011-011-9108-8

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  • DOI: https://doi.org/10.1007/s12011-011-9108-8

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