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Tissue Cadmium Accumulation is Associated with Basal Metabolic Rate in Mice

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Abstract

The objective of this study was to examine relations between basal metabolic rate (BMR) and cadmium (Cd) accumulation in the liver, kidneys, and duodenum in mice. The 5-month-old mice selected for high (H) and low (L) BMR were exposed for 8 weeks to 0, 10, and 100 μg Cd/mL of drinking water. The H-BMR mice showed significantly higher concentrations of Cd in the liver (47–79%), kidneys (61–70%), and duodenum (74–100%) than L-BMR animals. The tissue Cd accumulation also positively correlated with the duodenal iron which, in turn, was positively associated with BMR (Spearman R s = 0.81, P = 0.0004). The data indicate that tissue accumulation of Cd in mice is linked to BMR; the correlation between tissue Cd and duodenal iron suggests an involvement of iron transport pathway in the accumulation of Cd.

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References

  1. Satarug S, Baker JR, Urbenjapol S et al (2003) A global perspective on cadmium pollution and toxicity in non-occupationally exposed population. Toxicol Lett 137:65–83

    Article  PubMed  CAS  Google Scholar 

  2. Järup L, Berglund M, Elinder CG et al (1998) Health effects of cadmium exposure: a review of the literature and risk estimate. Skan J Work Environ Health 25:1–51

    Google Scholar 

  3. Larison JR, Likens GE, Fitzpatrick JW et al (2000) Cadmium toxicity among wildlife in the Colorado Rocky Mountains. Nature 406:181–183

    Article  PubMed  CAS  Google Scholar 

  4. Beiglböck C, Steineck T, Tataruch F et al (2002) Environmental cadmium induces histopathological changes in kidneys of roe deer. Environ Toxicol Chem 21:1811–1816

    Article  PubMed  Google Scholar 

  5. Włostowski T, Dmowski K, Bonda-Ostaszewska E (2010) Cadmium accumulation, metallothionein and glutathione levels, and histopathological changes in the kidneys and liver of magpie (Pica pica) from a zinc smelter area. Ecotoxicology 19:1066–1073

    Article  PubMed  Google Scholar 

  6. Nicholson JK, Kendal MD, Osborn D (1983) Cadmium and mercury nephrotoxicity. Nature 304:633–635

    Article  PubMed  CAS  Google Scholar 

  7. Groten JP, Koeman JH, van Nesselrooii JH et al (1994) Comparison of renal toxicity after long-term oral administration of cadmium chloride and cadmium-metallothionein in rats. Fundam Appl Toxicol 23:544–552

    Article  PubMed  CAS  Google Scholar 

  8. Liu J, Habeebu SM, Liu Y et al (1998) Acute CdMT injection is not a good model to study chronic Cd nephropathy; comparison of chronic CdCl2 and CdMT exposure with acute CdMT injection in rats. Toxicol Appl Pharmacol 153:48–58

    Article  PubMed  CAS  Google Scholar 

  9. Włostowski T, Bonda E, Krasowska A (2004) Photoperiod affects hepatic and renal cadmium accumulation, metallothionein induction, and cadmium toxicity in the wild bank vole (Clethrionomys glareolus). Ecotoxicol Environ Saf 58:29–36

    Article  PubMed  Google Scholar 

  10. Andersen O, Nielsen JB, Nordberg GF (2004) Nutritional interactions in intestinal cadmium uptake—possibilities for risk reduction. Biometals 17:543–547

    Article  PubMed  CAS  Google Scholar 

  11. Rummler HG, Classen HG, Schimatschek HF et al (1989) Age-dependent accumulation of cadmium in rats exposed to contaminated drinking water; interactions with zinc and copper and subcellular Cd distribution in kidney cells. J Trace Elem Electrolytes Health Dis 3:217–223

    PubMed  CAS  Google Scholar 

  12. Reeves PG, Chaney RL (2004) Marginal nutritional status of zinc, iron and calcium increases cadmium retention in the duodenum and other organs of rats fed rice-based diets. Environ Res 96:311–322

    Article  PubMed  CAS  Google Scholar 

  13. Raja KB, Jafri SE, Peters TJ et al (2006) Iron and cadmium uptake by duodenum of hypotransferrinaemic mice. Biometals 19:547–553

    Article  PubMed  CAS  Google Scholar 

  14. Flanagan PR, McLellan JS, Haist J et al (1978) Increased dietary cadmium absorption in mice and human subject with iron deficiency. Gastroenterology 74:841–846

    PubMed  CAS  Google Scholar 

  15. Raichlen DA, Gordon AD, Muchlinski MN et al (2010) Causes and significance of variation in mammalian basal metabolism. J Comp Physiol B 180:301–311

    Article  PubMed  Google Scholar 

  16. Konarzewski M, Diamond J (1995) Evolution of basal metabolic rate and organ masses in laboratory mice. Evolution 49:1239–1248

    Article  Google Scholar 

  17. Książek A, Konarzewski M, Łapo IB (2004) Anatomic and energetic correlates of divergent selection for basal metabolic rate in laboratory mice. Physiol Biochem Zool 77:890–899

    Article  PubMed  Google Scholar 

  18. Książek A, Czerniecki J, Konarzewski M (2009) Phenotypic flexibility of traits related to energy acquisition in mice divergently selected for basal metabolic rate (BMR). J Exp Biol 212:808–814

    Article  PubMed  Google Scholar 

  19. Tallkvist J, Bowlus CL, Lonnerdal B (2001) DMT1 gene expression and cadmium absorption in human absorptive enterocytes. Toxicol Lett 122:171–177

    Article  PubMed  CAS  Google Scholar 

  20. Park JD, Cherrington NJ, Klaassen CD (2002) Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats. Toxicol Sci 68:288–294

    Article  PubMed  CAS  Google Scholar 

  21. Rosenzweig PH, Volpe SL (1999) Iron, thermoregulation, and metabolic rate. Crit Rev Food Sci Nutr 39:131–148

    Article  PubMed  CAS  Google Scholar 

  22. Włostowski T, Krasowska A, Salińska A et al (2009) Seasonal changes of body iron status determine cadmium accumulation in the wild bank voles. Biol Trace Elem Res 131:291–297

    Article  PubMed  Google Scholar 

  23. Min K-S, Iwata N, Ueda H et al (2008) Effect of hemolytic and iron-deficiency anemia on intestinal absorption and tissue accumulation of cadmium. Toxicol Lett 179:48–52

    Article  PubMed  CAS  Google Scholar 

  24. Cannone-Hergaux F, Levy JE, Fleming MD et al (2001) Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. Blood 97:1138–1140

    Article  Google Scholar 

  25. Dupic F, Fruchon S, Bensaid M et al (2002) Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice. Gut 51:648–653

    Article  PubMed  CAS  Google Scholar 

  26. Ryu DY, Lee SJ, Park DW et al (2004) Dietary iron regulates intestinal cadmium absorption through iron transporters in rats. Toxicol Lett 152:19–25

    Article  PubMed  CAS  Google Scholar 

  27. Thijssen S, Maringwa J, Faes C et al (2007) Chronic exposure of mice to environmentally relevant, low doses of cadmium leads to early renal damage, not predicted by blood or urine cadmium levels. Toxicology 229:145–156

    Article  PubMed  CAS  Google Scholar 

  28. Chwełatiuk E, Włostowski T, Krasowska A et al (2006) The effect of orally administered melatonin on tissue accumulation and toxicity of cadmium in mice. J Trace Elem Med Biol 19:256–265

    Google Scholar 

  29. Leonard WR, Sorenson MV, Galloway VA et al (2002) Climatic influences on basal metabolic rate among circumpolar populations. Am J Hum Biol 14:609–620

    Article  PubMed  Google Scholar 

  30. Johansen P, Mulvad G, Pedersen HS et al (2006) Accumulation of cadmium in livers and kidneys in Greenlanders. Sci Total Environ 372:58–63

    Article  PubMed  CAS  Google Scholar 

  31. Lyon TDB, Aughey E, Scott R et al (1999) Cadmium concentrations in human kidney in the UK: 1978–1993. J Environ Monit 1:227–23

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Biology, University of Białystok, Świerkowa 20B, 15-950, Białystok, Poland

    Sebastian Maciak, Tadeusz Włostowski, Aneta Salińska & Elżbieta Bonda-Ostaszewska

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  1. Sebastian Maciak
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  2. Tadeusz Włostowski
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  3. Aneta Salińska
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  4. Elżbieta Bonda-Ostaszewska
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Correspondence to Tadeusz Włostowski.

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Maciak, S., Włostowski, T., Salińska, A. et al. Tissue Cadmium Accumulation is Associated with Basal Metabolic Rate in Mice. Biol Trace Elem Res 144, 944–950 (2011). https://doi.org/10.1007/s12011-011-9061-6

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  • DOI: https://doi.org/10.1007/s12011-011-9061-6

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