Calcium Fructoborate—Potential Anti-inflammatory Agent


Calcium fructoborate is a boron-based nutritional supplement. Its chemical structure is similar to one of the natural forms of boron such as bis-manitol, bis-sorbitol, bis-fructose, and bis-sucrose borate complexes found in edible plants. In vitro studies revealed that calcium fructoborate is a superoxide ion scavenger and anti-inflammatory agent. It may influence macrophage production of inflammatory mediators, can be beneficial for the suppression of cytokine production, and inhibits progression of endotoxin-associated diseases, as well as the boric acid and other boron sources. The mechanisms by which calcium fructoborate exerts its beneficial anti-inflammatory effects are not entirely clear, but some of its molecular biological in vitro activities are understood: inhibition of the superoxide within the cell; inhibition of the interleukin-1β, interleukin-6, and nitric oxide release in the culture media; and increase of the tumor necrosis factor-α production. Also, calcium fructoborate has no effects on lipopolysaccharide-induced cyclooxygenase-2 protein express. The studies on animals and humans with a dose range of 1–7 mg calcium fructoborate (0.025–0.175 mg elemental boron)/kg body weight/day exhibited a good anti-inflammatory activity, and it also seemed to have negligible adverse effect on humans.

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RS is a Professor in the Biochemistry Department, University of Craiova. RP is a Master of Conferences in the Department of Physics, University of Craiova.

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Correspondence to Romulus Ion Scorei.

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Scorei, R.I., Rotaru, P. Calcium Fructoborate—Potential Anti-inflammatory Agent. Biol Trace Elem Res 143, 1223–1238 (2011).

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  • Boron
  • Calcium fructoborate
  • Osteoporosis
  • Osteoarthritis
  • Anti-inflammatory
  • Antioxidant