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Biological Trace Element Research

, Volume 143, Issue 3, pp 1223–1238 | Cite as

Calcium Fructoborate—Potential Anti-inflammatory Agent

  • Romulus Ion ScoreiEmail author
  • Petre Rotaru
Article

Abstract

Calcium fructoborate is a boron-based nutritional supplement. Its chemical structure is similar to one of the natural forms of boron such as bis-manitol, bis-sorbitol, bis-fructose, and bis-sucrose borate complexes found in edible plants. In vitro studies revealed that calcium fructoborate is a superoxide ion scavenger and anti-inflammatory agent. It may influence macrophage production of inflammatory mediators, can be beneficial for the suppression of cytokine production, and inhibits progression of endotoxin-associated diseases, as well as the boric acid and other boron sources. The mechanisms by which calcium fructoborate exerts its beneficial anti-inflammatory effects are not entirely clear, but some of its molecular biological in vitro activities are understood: inhibition of the superoxide within the cell; inhibition of the interleukin-1β, interleukin-6, and nitric oxide release in the culture media; and increase of the tumor necrosis factor-α production. Also, calcium fructoborate has no effects on lipopolysaccharide-induced cyclooxygenase-2 protein express. The studies on animals and humans with a dose range of 1–7 mg calcium fructoborate (0.025–0.175 mg elemental boron)/kg body weight/day exhibited a good anti-inflammatory activity, and it also seemed to have negligible adverse effect on humans.

Keywords

Boron Calcium fructoborate Osteoporosis Osteoarthritis Anti-inflammatory Antioxidant 

Notes

Conflicts of interest

The authors have no relevant interests to declare.

Authors' information

RS is a Professor in the Biochemistry Department, University of Craiova. RP is a Master of Conferences in the Department of Physics, University of Craiova.

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of BiochemistryUniversity of CraiovaCraiovaRomania
  2. 2.Department of Physics II, Faculty of PhysicsUniversity of CraiovaCraiovaRomania

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