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Trace Elements in the Hair of Hemodialysis Patients

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Abstract

Trace element disturbance is often observed in hemodialysis patients. While trace element concentrations have been reported in blood samples from hemodialysis patients, they have not been well investigated in scalp hair. In the present study, 22 trace elemental concentrations were measured by inductively coupled plasma-atomic emission spectrometry in the scalp hair of 80 male hemodialysis patients and compared with those of 100 healthy male subjects. In hemodialysis patients, the concentrations of beryllium, arsenic, magnesium, chromium, manganese, iron, selenium, molybdenum, iodine, vanadium, and cobalt were significantly higher than those in healthy subjects, while lead, mercury, copper, germanium, and bromine were significantly lower than those in the former group. No significant differences were observed for lithium, aluminum, cadmium, zinc, boron, or nickel. There were significant positive correlations between the duration of hemodialysis and the magnesium and manganese concentrations. There was a significant negative correlation between cadmium concentration and the duration of hemodialysis. There were significant positive correlations between dialysis efficacy (Kt/V) and magnesium, manganese, zinc, and selenium concentrations. In conclusion, trace element concentrations of the scalp hair are different between hemodialysis patients and healthy subjects. Essential trace elements, such as magnesium, manganese, zinc, and selenium, may be affected by the duration of hemodialysis and Kt/V.

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References

  1. Smythe WR, Alfrey AC, Craswell PW, Crouch CA, Ibels LS, Kubo H, Nunnelley LL, Rudolph H (1982) Trace element abnormalities in chronic uremia. Ann Intern Med 96:302–310

    PubMed  CAS  Google Scholar 

  2. Lee SH, Huang JW, Hung KY, Leu LJ, Kan YT, Yang CS, Chung Wu D, Huang CL, Chen PY, Chen JS, Chen WY (2000) Trace metals' abnormalities in hemodialysis patients: relationship with medications. Artif Organs 24:841–844

    Article  PubMed  CAS  Google Scholar 

  3. Rucker D, Thadhani R, Tonelli M (2010) Trace element status in hemodialysis patients. Semin Dial 23:389–395

    Article  PubMed  Google Scholar 

  4. Tonelli M, Wiebe N, Hemmelgarn B, Klarenbach S, Field C, Manns B, Thadhani R, Gill J (2009) Trace elements in hemodialysis patients: a systematic review and meta-analysis. BMC Med 7:25

    Article  PubMed  Google Scholar 

  5. Yasuda H, Yoshida K, Segawa M, Tokuda R, Tsutsui T, Yasuda Y, Magara S (2009) Metallomics study using hair mineral analysis and multiple logistic regression analysis: relationship between cancer and minerals. Environ Health Prev Med 14:261–266

    Article  PubMed  CAS  Google Scholar 

  6. Pasha Q, Malik SA, Shaheen N, Shah MH (2010) Investigation of trace metals in the blood plasma and scalp hair of gastrointestinal cancer patients in comparison with controls. Clin Chim Acta 411:531–539

    Article  PubMed  CAS  Google Scholar 

  7. Pasha Q, Malik SA, Shaheen N, Shah MH (2010) Comparison of trace elements in the scalp hair of malignant and benign breast lesions versus healthy women. Biol Trace Elem Res 134:160–173

    Article  PubMed  CAS  Google Scholar 

  8. Gonzalez-Munoz MJ, Sanchez-Muniz FJ, Rodenas S, Sevillano MI, Larrea Marin MT, Bastida S (2010) Differences in metal and metalloid content in the hair of normo- and hypertensive postmenopausal women. Hypertens Res 33:219–224

    Article  PubMed  CAS  Google Scholar 

  9. Afridi HI, Kazi TG, Kazi NG, Jamali MK, Arain MB, Sirajuddin BJA, Kandhro GA, Wadhwa SK, Shah AQ (2010) Evaluation of cadmium, lead, nickel and zinc status in biological samples of smokers and nonsmokers hypertensive patients. J Hum Hypertens 24:34–43

    Article  PubMed  CAS  Google Scholar 

  10. Afridi HI, Kazi TG, Kazi N, Kandhro GA, Baig JA, Shah AQ, Jamali MK, Arain MB (2010) Evaluation of toxic elements in scalp hair samples of myocardial infarction patients at different stages as related to controls. Biol Trace Elem Res 134:1–12

    Article  PubMed  CAS  Google Scholar 

  11. Kim OY, Baek SH, Lee YJ, Lee KH (2010) Association of increased hair calcium levels and enhanced augmentation index (AIx): a marker of arterial stiffness. Biol Trace Elem Res 138:90-98

    Google Scholar 

  12. Hac E, Czarnowski W, Gos T, Krechniak J (1997) Lead and fluoride content in human bone and hair in the Gdansk region. Sci Total Environ 206:249–254

    PubMed  CAS  Google Scholar 

  13. Kazi TG, Afridi HI, Kazi GH, Jamali MK, Arain MB, Jalbani N (2006) Evaluation of essential and toxic metals by ultrasound-assisted acid leaching from scalp hair samples of children with macular degeneration patients. Clin Chim Acta 369:52–60

    Article  PubMed  CAS  Google Scholar 

  14. Goulle JP, Mahieu L, Castermant J, Neveu N, Bonneau L, Laine G, Bouige D, Lacroix C (2005) Metal and metalloid multi-elementary ICP-MS validation in whole blood, plasma, urine and hair. Reference values. Forensic Sci Int 153:39–44

    Article  PubMed  CAS  Google Scholar 

  15. Dlugaszek M, Szopa M, Rzeszotarski J, Karbowiak P (2008) Magnesium, calcium and trace elements distribution in serum, erythrocytes, and hair of patients with chronic renal failure. Magnes Res 21:109–117

    PubMed  CAS  Google Scholar 

  16. Kazi TG, Jalbani N, Kazi N, Arain MB, Jamali MK, Afridi HI, Kandhro GA, Sarfraz RA, Shah AQ, Ansari R (2009) Estimation of toxic metals in scalp hair samples of chronic kidney patients. Biol Trace Elem Res 127:16–27

    Article  PubMed  CAS  Google Scholar 

  17. Hayashi M (1990) Factors involved in trace element metabolic abnormalities in hemodialysis patients. Tokushima J Exp Med 37:103–115

    PubMed  CAS  Google Scholar 

  18. Marumo F, Tsukamoto Y, Iwanami S, Kishimoto T, Yamagami S (1984) Trace element concentrations in hair, fingernails and plasma of patients with chronic renal failure on hemodialysis and hemofiltration. Nephron 38:267–272

    Article  PubMed  CAS  Google Scholar 

  19. Yasuda H, Yonashiro T, Yoshida K, Ishii T, Tsutsui T (2005) High toxic metal levels in scalp hair of infants and children. Biomed Res Trace Elem 16:39–45

    CAS  Google Scholar 

  20. Hosokawa S, Yoshida O (1994) Clinical studies on molybdenum in patients requiring long-term hemodialysis. ASAIO J 40:M445–M449

    Article  PubMed  CAS  Google Scholar 

  21. Rayman MP (2000) The importance of selenium to human health. Lancet 356:233–241

    Article  PubMed  CAS  Google Scholar 

  22. Klotz LO, Kroncke KD, Buchczyk DP, Sies H (2003) Role of copper, zinc, selenium and tellurium in the cellular defense against oxidative and nitrosative stress. J Nutr 133:1448S–1451S

    PubMed  CAS  Google Scholar 

  23. Dworkin B, Weseley S, Rosenthal WS, Schwartz EM, Weiss L (1987) Diminished blood selenium levels in renal failure patients on dialysis: correlations with nutritional status. Am J Med Sci 293:6–12

    Article  PubMed  CAS  Google Scholar 

  24. Ward RA, McLeish KR (2003) Oxidant stress in hemodialysis patients: what are the determining factors? Artif Organs 27:230–236

    Article  PubMed  CAS  Google Scholar 

  25. Hsieh YY, Shen WS, Lee LY, Wu TL, Ning HC, Sun CF (2006) Long-term changes in trace elements in patients undergoing chronic hemodialysis. Biol Trace Elem Res 109:115–121

    Article  PubMed  CAS  Google Scholar 

  26. Alfrey AC, LeGendre GR, Kaehny WD (1976) The dialysis encephalopathy syndrome. Possible aluminum intoxication. N Engl J Med 294:184–188

    Article  PubMed  CAS  Google Scholar 

  27. Van Renterghem D, Cornelis R, Vanholder R (1992) Behaviour of 12 trace elements in serum of uremic patients on hemodiafiltration. J Trace Elem Electrolytes Health Dis 6:169–174

    PubMed  Google Scholar 

  28. Pershagen G, Hast R, Lins LE, Pehrsson K (1982) Increased arsenic concentration in the bone marrow in chronic renal failure—a contributor to anaemia? Nephron 30:250–252

    Article  PubMed  CAS  Google Scholar 

  29. Schoen A, Beck B, Sharma R, Dube E (2004) Arsenic toxicity at low doses: epidemiological and mode of action considerations. Toxicol Appl Pharmacol 198:253–267

    Article  PubMed  CAS  Google Scholar 

  30. Zhang X, Cornelis R, De Kimpe J, Mees L, Vanderbiesen V, De Cubber A, Vanholder R (1996) Accumulation of arsenic species in serum of patients with chronic renal disease. Clin Chem 42:1231–1237

    PubMed  CAS  Google Scholar 

  31. Xue W, Wang Z, Chen Q, Chen J, Yang H, Xue S (2010) High selenium status in individuals exposed to arsenic through coal-burning in Shaanxi (PR of China) modulates antioxidant enzymes, heme oxygenase-1 and DNA damage. Clin Chim Acta 411:1312-1318

    Google Scholar 

  32. Huang Z, Pei Q, Sun G, Zhang S, Liang J, Gao Y, Zhang X (2008) Low selenium status affects arsenic metabolites in an arsenic exposed population with skin lesions. Clin Chim Acta 387:139–144

    Article  PubMed  CAS  Google Scholar 

  33. Sakurai H (2002) A new concept: the use of vanadium complexes in the treatment of diabetes mellitus. Chem Rec 2:237–248

    Article  PubMed  CAS  Google Scholar 

  34. Thompson KH, Lichter J, LeBel C, Scaife MC, McNeill JH, Orvig C (2009) Vanadium treatment of type 2 diabetes: a view to the future. J Inorg Biochem 103:554–558

    Article  PubMed  CAS  Google Scholar 

  35. Foller M, Sopjani M, Mahmud H, Lang F (2008) Vanadate-induced suicidal erythrocyte death. Kidney Blood Press Res 31:87–93

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Nephrology, Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan

    Akinobu Ochi, Eiji Ishimura, Katsuhito Mori, Tetsuo Shoji, Yoshiki Nishizawa & Masaaki Inaba

  2. Inoue Hospital, 16-17, Enoki-chou, Suita, Osaka, 564-0053, Japan

    Yoshihiro Tsujimoto, Ryusuke Kakiya & Tsutomu Tabata

  3. Research Laboratory, La Bell Vie Inc., 8-4, Nihonbashi-Tomizawachou, Chuo-ku, Tokyo, 103-0006, Japan

    Hiroshi Yasuda

Authors
  1. Akinobu Ochi
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  2. Eiji Ishimura
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  3. Yoshihiro Tsujimoto
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  4. Ryusuke Kakiya
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  5. Tsutomu Tabata
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  6. Katsuhito Mori
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  7. Tetsuo Shoji
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  8. Hiroshi Yasuda
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  9. Yoshiki Nishizawa
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  10. Masaaki Inaba
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Correspondence to Eiji Ishimura.

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Ochi, A., Ishimura, E., Tsujimoto, Y. et al. Trace Elements in the Hair of Hemodialysis Patients. Biol Trace Elem Res 143, 825–834 (2011). https://doi.org/10.1007/s12011-010-8948-y

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  • DOI: https://doi.org/10.1007/s12011-010-8948-y

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