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Chromium and Manganese Levels in Biological Samples of Pakistani Myocardial Infarction Patients at Different Stages as Related to Controls

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An Erratum to this article was published on 23 December 2010

An Erratum to this article was published on 23 December 2010

Abstract

It has been speculated that trace elements may play a role in the pathogenesis of heart diseases In the present study, we aimed to access the levels of chromium (Cr) and manganese (Mn) in biological samples (whole blood, urine, and scalp hair) of myocardial infarction (MI) patients of both gender age ranged (45–60 years) at first, second, and third heart attack (n = 130), hospitalized in cardiac ward of National Hospital of Hyderabad city (Pakistan). For comparison, healthy age-matched referent subjects (n = 61), of both gender were also selected. The Cr and Mn in biological samples were measured by electrothermal atomic absorption spectrometry, prior to microwave-assisted acid digestion. The validity of the methodology was checked by the biological certified reference materials. During this study, 78% of 32 registered patients of third MI attack (aged >50 years) were died. In these subjects the concentration of Cr and Mn were decreased by 24.7% and 19.8% in scalp hair, while in blood samples 17.9% and 12.4%, respectively, as compared to those who tolerated third MI attack (p = 0.063). Although these data do not prove a causal relationship, these results are consistent with the hypothesis that heart disease may cause deficiencies of certain essential trace elements. The excretion levels of Cr and Mn in urine samples of first MCI were higher than controls at p values (0.029 and 0.011), respectively, whereas the excretion rates of both elements were further enhance after second myocardial infarction attack. The Cr and Mn concentration was inversely associated with the risk of myocardial infarction attacks in both genders. These results add to an increasing body of evidence that, Cr and Mn are importance for cardiovascular health.

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Acknowledgment

The authors thank the Higher Education Commission of Pakistan for sponsoring this project.

Conflict of interest

None.

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Authors and Affiliations

  1. National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan

    Hassan Imran Afridi, Tasneem Gul Kazi,  Sirajuddin, Ghulam Abbas Kandhro, Jameel Ahmed Baig, Abdul Qadir Shah, Mohammad Khan Jamali, Mohammad Balal Arain, Sham Kumar Wadhwa, Sumaira Khan, Nida Fatima Kolachi & Faheem Shah

  2. Mechanical and Manufacturing Engineering, Dublin City University, Dublin, Ireland

    Hassan Imran Afridi

  3. Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan

    Naveed Kazi

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  1. Hassan Imran Afridi
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  2. Tasneem Gul Kazi
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Correspondence to Hassan Imran Afridi.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s12011-010-8923-7

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Afridi, H.I., Kazi, T.G., Kazi, N. et al. Chromium and Manganese Levels in Biological Samples of Pakistani Myocardial Infarction Patients at Different Stages as Related to Controls. Biol Trace Elem Res 142, 259–273 (2011). https://doi.org/10.1007/s12011-010-8773-3

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