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Mineral Elements in the Hair of Amblyopic Children

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Abstract

Amblyopia is a common cause of vision damage in children, and some aspects of its etiology are not clear. A number of mineral elements have important effects on the nerve and visual nerve systems. However, little is known about the relationship between amblyopia and nutritional mineral elements. In this study, hair samples were collected from 67 children with amblyopia and 57 age-matched control groups. The height and weight of each child was measured, and body mass index (BMI) was calculated. Mineral elements were determined by atomic absorption spectrometry and inductively coupled plasma-atomic emission spectrometry. The calcium and magnesium levels in the hair of amblyopic children were higher (p < 0.006), but the level of manganese were lower compared with those in the control groups (p < 0.006). Other elements measured were found to have an insignificant difference between the two groups (p > 0.006). The BMI of amblyopic children was higher (p < 0.001). These results show that mineral elements may play an important role in the visual development of children. Therefore, studies should pay more attention to investigating the impact of mineral elements on child vision.

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References

  1. Carlton J, Karnon J, Czoski-Murray C et al (2008) The clinical effectiveness and cost-effectiveness of screening programmes for amblyopia and strabismus in children up to the age of 4-5 years: a systematic review and economic evaluation. Health Technol Assess 12(iii):xi–194

    Google Scholar 

  2. Daw NW (1998) Critical periods and amblyopia. Arch Ophthalmol 116:502–505

    PubMed  CAS  Google Scholar 

  3. Galin MA, Nano HD, Hall T (1962) Ocular zinc concentration. Invest Ophthalmol 1:142–148

    PubMed  CAS  Google Scholar 

  4. Koh JY, Choi DW (1988) Zinc alters excitatory amino acid neurotoxicity on cortical neurons. Neurosci 8:2164–2171

    CAS  Google Scholar 

  5. Kim HJ, Kim YY, Kim SY (2000) Effect of zinc on the visual sensitivity of the bullfrog's eye. Korean J Ophthalmol 14:53–59

    PubMed  CAS  Google Scholar 

  6. Pasha Q, Malik SA, Shaheen N et al (2010) Comparison of trace elements in the scalp hair of malignant and benign breast lesions versus healthy women. Biol Trace Elem Res 134:160–173

    Article  PubMed  CAS  Google Scholar 

  7. Kazi TG, Jalbani N, Kazi N et al (2009) Estimation of toxic metals in scalp hair samples of chronic kidney patients. Biol Trace Elem Res 127:16–27

    Article  PubMed  CAS  Google Scholar 

  8. Rahman A, Azad MA, Hossain I et al (2009) Zinc, manganese, calcium, copper, and cadmium level in scalp hair samples of schizophrenic patients. Biol Trace Elem Res 127:102–108

    Article  PubMed  CAS  Google Scholar 

  9. Wang CT, Chang WT, Zeng WF, Lin CH (2005) Concentrations of calcium, copper, iron, magnesium, potassium, sodium and zinc in adult female hair with different body mass indexes in Taiwan. Clin Chem Lab Med 43:389–393

    Article  PubMed  CAS  Google Scholar 

  10. Forte G, Alimonti A, Violante N, Di Gregorio M, Senofonte O, Petrucci F, Sancesario G, Bocca B (2005) Calcium, copper, iron, magnesium, silicon and zinc content of hair in Parkinson's disease. J Trace Elem Med Biol 19:195–203

    Article  PubMed  CAS  Google Scholar 

  11. AAO Pediatric Ophthalmology/Strabismus PPP Panel, Hoskins Center for Quality Eye Care (2007) Amblyopia PPP-September 2007. In: Preferred practice patterns: American Academy of Ophthalmology. Available via DIALOG. http://one.aao.org. Accessed 15 Jan 2009

  12. Murphy KM, Duffy KR, Jones DG (2004) Experience-dependent changes in NMDAR1 expression in the visual cortex of an animal model for amblyopia. Vis Neurosci 21:653–670

    Article  PubMed  Google Scholar 

  13. Kato N, Yoshimura H (1993) Reduced Mg2+ block of N-methyl-d-aspartate receptor-mediated synaptic potentials in developing visual cortex. Proc Natl Acad Sci U S A 90:7114–7118

    Article  PubMed  CAS  Google Scholar 

  14. Liu Y, Zhang J (2000) Recent development in NMDA receptors. Chin Med J (Engl) 113:948–956

    CAS  Google Scholar 

  15. Yuki K, Dogru M, Imamura Y, Kimura I, Othtake Y, Tsubota K (2009) Lead accumulation as possiblerisk factor for primary open-angle glaucoma. Biol Trace Elem Res 132:1–8

    Article  PubMed  CAS  Google Scholar 

  16. Gong H, Amemiya T (2000) Ultrastructure of retina of manganese-deficient rats. Invest Ophthalmol Vis Scix 37:1967–1974

    Google Scholar 

  17. Endo K, Itoh N, Maehara S et al (2008) Functional disorder of the retina in manganese-deficient Japanese quail revealed by electroretinography using a contact lens electrode with built-in light source. J Vet Med Sci 70:139–144

    Article  PubMed  Google Scholar 

  18. Uz E, Sahin S, Hepsen IF (2003) The relationship between serum trace element changes and visual function in heavy smokers. Acta Ophthalmol Scand 81:161–164

    Article  PubMed  CAS  Google Scholar 

  19. Gong H, Amemiya T (2001) Optic nerve changes in zinc-deficient rats. Exp Eye Res 72:363–369

    Article  PubMed  CAS  Google Scholar 

  20. Amemiya T (1985) Retinal changes in the selenium deficient rat. Int J Vitam Nutr Res 55:233–237

    PubMed  CAS  Google Scholar 

  21. Jin M, Yan W, Li X (2005) The relationship between amblyopia in children and trace element selenium and clinical significance. Chin J Mater Child Health Care 20:2549–2551

    Google Scholar 

  22. Chen Y, Zhu W, Zhou J et al (2006) Analysis on trace elements in serum of amblyopia children. Guangdong Trace Elem Sci 13:17–20

    CAS  Google Scholar 

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Correspondence to XinJun Yang.

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Zhu, Q., Chen, J., Zheng, M. et al. Mineral Elements in the Hair of Amblyopic Children. Biol Trace Elem Res 141, 119–125 (2011). https://doi.org/10.1007/s12011-010-8730-1

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  • DOI: https://doi.org/10.1007/s12011-010-8730-1

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